Journal of Surgical Research
Volume 138, Issue 1 , Pages 64-70 , March 2007

Effects of Plasma Fibronectin on the Healing of Full-Thickness Skin Wounds in Streptozotocin-Induced Diabetic Rats

  • Zeyu Qiu, Ph.D.
  • ,
  • A.-Hon Kwon, M.D.

      Affiliations

    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Kansai Medical University, 10-15 Fumizono, Moriguchi, Osaka, 570-8507, Japan.
  • ,
  • Yasuo Kamiyama, M.D.

Received 10 January 2006

References 

  1. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738
  2. Hehenberger K, Hansson A, Heilborn JD, Abdel-Halim SM, Ostensson CG, Brismar K. Inhibited proliferation of fibroblasts derived from chronic diabetic wounds and normal dermal fibroblasts treated with high glucose is associated with increased formation of l-lactate. Wound Repair Regen. 1998;6:135
  3. Marhoffer W, Stein M, Maeser E, Federlin K. Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes. Diabetes Care. 1992;15:256
  4. Beer HD, Longaker MT, Werner S. Reduced expression of PDGF and PDGF receptors during impaired wound healing. J Invest Dermatol. 1997;109:132
  5. Hehenberger K, Hansson A, Heilborn JD, Abdel-Halim SM, Ostensson CG, Brismar K. Impaired proliferation and increased L-lactate production of dermal fibroblasts in the GK-rat, a spontaneous model of non-insulin dependent diabetes mellitus. Wound Repair Regen. 1999;7:65
  6. Pankov R, Yamada KM. Fibronectin at a glance. J Cell Sci. 2002;115:3861
  7. Grinnell F. Fibronectin and wound healing. J Cell Biochem. 1984;26:107
  8. Wysocki AB, Grinnell F. Fibronectin profiles in normal and chronic wound fluid. Lab Invest. 1990;63:825
  9. Labat-Robert J, Leutenegger M, Llopis G, Ricard Y, Derouette JC. Plasma and tissue fibronectin in diabetes. Clin Physiol Biochem. 1984;2:39
  10. Di Girolamo N, Underwood A, McCluskey PJ, Wakefield D. Functional activity of plasma fibronectin in patients with diabetes mellitus. Diabetes. 1993;42:1606
  11. Nakamura M, Sato N, Chikama T, Hasegawa Y, Nishida T. Fibronectin facilitates corneal epithelial wound healing in diabetic rats. Exp Eye Res. 1997;64:355
  12. Edwards CA, O’Brien WD. Modified assay for determination of hydroxyproline in a tissue hydrolyzate. Clin Chim Acta. 1980;104:161
  13. Elias D, Prigozin H, Polak N, Rapoport M, Lohse AW, Cohen IR. Autoimmune diabetes induced by the beta-cell toxin STZ (Immunity to the 60-kDa heat shock protein and to insulin). Diabetes. 1994;43:992
  14. Candela S, Hernandez RE, Gagliardino JJ. Circadian variation of the streptozotocin-diabetogenic effect in mice. Experientia. 1979;35:1256
  15. Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet Med. 2005;22:359
  16. Reagan LP, Magarinos AM, McEwen BS. Neurological changes induced by stress in streptozotocin diabetic rats. Ann N Y Acad Sci. 1999;893:126
  17. Hoogwerf BJ. Postoperative management of the diabetic patient. Med Clin North Am. 2001;85:1213
  18. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83:835
  19. O’Kane S, Ferguson MW. Transforming growth factor beta s and wound healing. Int J Biochem Cell Biol. 1997;29:63
  20. Yu W, Naim JO, Lanzafame RJ. Expression of growth factors in early wound healing in rat skin. Lasers Surg Med. 1994;15:281
  21. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993;122:103
  22. Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF. Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science. 1987;237:1333
  23. Serini G, Bochaton-Piallat ML, Ropraz P, et al. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol. 1998;142:873
  24. Crowe MJ, Doetschman T, Greenhalgh DG. Delayed wound healing in immunodeficient TGF-beta 1 knockout mice. J Invest Dermatol. 2000;115:3
  25. Jude EB, Blakytny R, Bulmer J, Boulton AJ, Ferguson MW. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Diabet Med. 2002;19:440
  26. Benn SI, Whitsitt JS, Broadley KN, et al. Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. J Clin Invest. 1996;98:2894
  27. Desmouliere A, Gabbiani G. Modulation of fibroblastic cytoskeletal features during pathological situations: The role of extracellular matrix and cytokines. Cell Motil Cytoskeleton. 1994;29:195
  28. Frank S, Madlener M, Werner S. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem. 1996;271:10188
  29. Thomas GJ, Nystrom ML, Marshall JF. alphavbeta6 integrin in wound healing and cancer of the oral cavity. J Oral Pathol Med. 2006;35:1
  30. Dallas SL, Sivakumar P, Jones CJ, et al. Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem. 2005;280:18871
  31. Greiling D, Clark RA. Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrix. Cell Sci. 1997;110:861
  32. O’Keefe EJ, Payne RE, Russell N, Woodley DT. Spreading and enhanced motility of human keratinocytes on fibronectin. J Invest Dermatol. 1985;85:125
  33. Canfield AE, Schor AM, Loskutoff DJ, Schor SL, Grant ME. Plasminogen activator inhibitor-type I is a major biosynthetic product of retinal microvascular endothelial cells and pericytes in culture. Biochem J. 1989;259:529
  34. Kohn FR, Klingemann HG. Regulation of fibronectin receptor (alpha 5 beta 1) mRNA expression in human monocytes and monocyte-derived macrophages by activation/differentiation signals. Exp Hematol. 1991;19:653
  35. Herard AL, Pierrot D, Hinnrasky J, et al. Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium. Am J Physiol. 1996;271:L726
  36. Quan G, Choi JY, Lee DS, Lee SC. TGF-beta1 up-regulates transglutaminase two and fibronectin in dermal fibroblasts: A possible mechanism for the stabilization of tissue inflammation. Arch Dermatol Res. 2005;297:84
  37. Roberts CJ, Birkenmeier TM, McQuillan JJ, et al. Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts. J Biol Chem. 1988;263:4586

PII: S0022-4804(06)00315-5

doi: 10.1016/j.jss.2006.06.034

Journal of Surgical Research
Volume 138, Issue 1 , Pages 64-70 , March 2007