Journal of Surgical Research
Volume 138, Issue 1 , Pages 45-50 , March 2007

Influence of Fructose-1,6-Diphosphate on Endotoxin-Induced Lung Injuries in Sheep

  • Angel K. Markov, M.D.

      Affiliations

    • Division of Cardiovascular Diseases, Department of Medicine, Jackson State University, University of Mississippi Medical Center, Jackson, Mississippi
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Division of Cardiovascular Diseases, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216.
    • ,
  • E. Taliferio Warren, M.D.

      Affiliations

    • Division of Cardiovascular Surgery, Jackson State University, University of Mississippi Medical Center, Jackson, Mississippi
    • ,
  • Hari H.P. Cohly, Ph.D.

      Affiliations

    • Department of Biology, Jackson State University, University of Mississippi Medical Center, Jackson, Mississippi
    • ,
  • David J. Sauls, M.D.

      Affiliations

    • Division of Cardiovascular Surgery, Jackson State University, University of Mississippi Medical Center, Jackson, Mississippi
    • ,
  • Thomas N. Skelton, M.D.

      Affiliations

    • Division of Cardiovascular Diseases, Department of Medicine, Jackson State University, University of Mississippi Medical Center, Jackson, Mississippi

Received 17 December 2004

References 

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  5. Markov AK, Turner MD, Oglethorpe N, Hellems HK. Fructose-1, 6-diphosphate: An agent for treatment of experimental endotoxin shock. Surgery. 1981;90:482
  6. Markov AK, Oglethorpe N, Grillis M, Neely WA, Hellems HK. Therapeutic action of fructose 1-6 diphosphate in traumatic shock. World J Surg. 1983;7:430
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  8. Figueroa AH, Stone RH, Cohly HHP, Lehan PH, Markov AK. Effect of fructose-1,6-diphosphate versus diphenhydramine on mortality in compound 48/80-induced shock. Toxicol Lett. 2001;122:141
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  10. Markov AK. Hemodynamic and metabolic effects of fructose-1,6-diphosphate (FDP) in ischemia and shock-experimental and clinical observations. Ann Emerg Med. 1986;15:1470
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  22. Markov AK, Rayburn TS, Talton DS, et al. Fructose-I, 6-diphosphate alone and in combination with cyclosporine potentiates rat cardiac allograft survival and inhibits lymphocyte proliferation and interleukin-2 expression. Transplantation. 2002;74:1651
  23. Cohly H, Jenkins J, Skelton T, Meydrech E, Markov AK. Fructose-I, 6-diphosphate suppresses T-lymphocyte proliferation, promotes apoptosis and inhibits interleukins-1, β-actin mRNAs, and transcription factors expression. Immunol Invest. 2004;33:407
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PII: S0022-4804(06)00320-9

doi: 10.1016/j.jss.2006.06.038

Journal of Surgical Research
Volume 138, Issue 1 , Pages 45-50 , March 2007

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