« Previous
Next »
Journal of Surgical Research
Volume 138, Issue 1
, Pages 37-44
, March 2007
Rapamycin Inhibits Proliferation of Estrogen-Receptor-Positive Breast Cancer Cells
References
- . Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 2003;35:7S
- . The pleiotropic effects of mTor inhibitors. J Nephrol. 2004;17:762
- Drug-eluting stents: results, promises and problems. Int J Cardiol. 2005;99:9
- Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst. 1991;83:757
- . Clinical development of mammalian target of rapamycin inhibitors. Hematol Oncol Clin North Am. 2002;16:1101
- . Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol. 2003;4:117
- . The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene. 2000;19:6680
- Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005;69:79
- 2005 Cancer Facts and Figures. American Cancer Society.
- . Towards a molecular basis for tamoxifen resistance in breast cancer. Ann Oncol. 1992;3:503
- mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer. 2001;8:249
- Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature. 2000;407:538
- Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Res. 2001;61:5985
- . Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 1984;22:27
- . Mechanisms of estrogen receptor signaling: convergence of genomic and non-genomic actions on target genes. Mol Endocrinol. 2005;19:833
- Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Mol Endocrinol. 2003;17:818
- mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004;10:594
- Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res. 2004;10:1013
- An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice. Proc Natl Acad Sci USA. 2001;98:10320
- . Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity. J Steroid Biochem Mol Biol. 2000;75:11
- Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res. 2004;10:8059
- . Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther. 2003;2:222
- . Tamoxifen (“Nolvadex”): a review. Cancer Treat Rev. 2002;28:165
- A phase Ib study of the mTOR inhibitor RAD001 (everolimus) in combination with letrozole (Femara), investigating safety and pharmacokinetics in patients with advanced breast cancer stable or slowly progressing on letrozole [Abstract]. Breast Cancer Res Treat. 2004;88:S234
PII: S0022-4804(06)00358-1
doi: 10.1016/j.jss.2006.07.003
© 2007 Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Surgical Research
Volume 138, Issue 1
, Pages 37-44
, March 2007
