Journal of Surgical Research
Volume 139, Issue 1 , Pages 30-35 , 1 May 2007

The Sinusoidal Pressure During Ischemia-Reperfusion Injury in Perfused Mouse Liver Pretreated With or Without l-NAME

  • Toshishige Shibamoto, M.D.

      Affiliations

    • Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293.
  • ,
  • Zonghai Ruan, M.D.

      Affiliations

    • Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa, Japan
  • ,
  • Sen Cui, M.D.

      Affiliations

    • Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa, Japan
  • ,
  • Wei Liu, M.D.

      Affiliations

    • Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa, Japan
  • ,
  • Zhan-Sheng Zhao, M.D.

      Affiliations

    • Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa, Japan
  • ,
  • Hiromichi Takano, Ph.D.

      Affiliations

    • Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa, Japan
  • ,
  • Yasutaka Kurata, M.D.

      Affiliations

    • Department of Physiology, Kanazawa Medical University, Uchinada Ishikawa, Japan
  • ,
  • Tomonobu Koizumi, M.D.

      Affiliations

    • First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
  • ,
  • Keishi Kubo, M.D.

      Affiliations

    • First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Received 5 April 2006

References 

  1. Clavien PA, Harvey PR, Strasberg SM. Preservation and reperfusion injuries in liver allografts. Transplantation. 1992;53:957
  2. Delva E, Barberousse JP, Nordlinger B, et al. Hemodynamic and biochemical monitoring during major liver resection with use of hepatic vascular exclusion. Surgery. 1984;95:309
  3. Wang KS, Monden M, Kanai T, et al. Protective effects of a PAF antagonist against liver injury induced by warm ischemia or cold preservation. Transplant Proc. 1992;24:1596
  4. Ling YQ, Shibamoto T, Honda T, et al. Increased sinusoidal pressure is associated with early liver weight gain in ischemiareperfusion injury in isolated perfused rat liver. J Surg Res. 2000;88:70
  5. Shibamoto T, Cui S, Ruan Z, et al. Effects of norepinephrine and histamine on vascular resistance in isolated perfused mouse liver. Jpn J Physiol. 2005;55:143
  6. McCuskey RS. Morphological mechanisms for regulating blood flow through hepatic sinusoids. Liver. 2000;20:3
  7. Ming Z, Han C, Lautt WW. Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction. Am J Physiol Gastrointest Liver Physiol. 1999;277:G1200
  8. Wiest R, Groszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology. 2002;35:478
  9. Chun K, Zhang J, Biewer J, et al. Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers. Shock. 1994;1:3
  10. Koo A, Komatsu H, Tao G, et al. Contribution of noreflow phenomenon to hepatic injury after ischemia-reperfusion: Evidence for a role for superoxide anion. Hepatology. 1991;15:507
  11. Vollmar B, Glasz J, Leiderer R, et al. Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol. 1994;145:1421
  12. Squadrito GL, Pryor WA. Oxidative chemistry of nitric oxide: The role of superoxide, peroxynitrite and carbon dioxide. Free Radic Biol Med. 1998;25:392
  13. Menezes J, Hierholzer C, Watkins SC, et al. A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock. Am J Physiol. 1999;277:G144
  14. Meguro M, Katsuramaki T, Nagayama M, et al. A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver. Transplantation. 2002;73:1439
  15. Wang Y, Mathews WR, Guido DM, et al. Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia. Shock. 1995;4:282
  16. Liu P, Yin K, Nagele R, Wong PY. Inhibition of nitric oxide synthase attenuates peroxynitrite generation, but augments neutrophil accumulation in hepatic ischemiareperfusion in rats. J Pharmacol Exp Ther. 1998;284:1139
  17. Yamaguchi Y, Shibamoto T, Hayashi T, et al. Hepatic vascular response to anaphylaxis in isolated canine liver. Am J Physiol. 1994;267:R268
  18. Kukan M, Bezek S, Tmovec T. Role of hepatovasculature in warm ischemiareperfusion injury of rat liver. Physiol Res. 1996;45:427
  19. Minor T, Isselhard W. Role of the hepatovasculature in free radical mediated reperfusion damage of the liver. Eur Surg Res. 1993;25:287
  20. Gores GJ, Flarsheim CE, Dawson TL, et al. Swelling, reductive stress and cell death during chemical hypoxia in hepatocytes. Am J Physiol. 1989;257:C347
  21. McCuskey RS, McCuskey PA, Urbaschek R, et al. Kupffer cell function in host defense. Rev Infect Dis. 1987;9:S616
  22. Caldwell-Kenkel JC, Currin RT, Tanaka Y, et al. Kupffer cell activation and endothelial damage after storage of rat livers: Effects of reperfusion. Hepatology. 1991;13:83
  23. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem. 1990;192:245
  24. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol. 2003;284:G15
  25. Harbrecht BG, Wu B, Watkins SC, et al. Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury. Shock. 1995;332:
  26. Gauthier TW, Davenpeck KL, Lefer AM. Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion. Am J Physiol. 1994;G562:

PII: S0022-4804(06)00402-1

doi: 10.1016/j.jss.2006.07.052

Journal of Surgical Research
Volume 139, Issue 1 , Pages 30-35 , 1 May 2007