Journal of Surgical Research
Volume 139, Issue 1 , Pages 45-50 , 1 May 2007

Beneficial Effects of Phosphatidylcholine During Hindlimb Reperfusion

  • László Gera, M.D.

      Affiliations

    • Department of Traumatology, Kecskemét County Hospital, Kecskemét, Hungary
    • Institute of Surgical Research, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • ,
  • Renáta Varga, M.D.

      Affiliations

    • Institute of Surgical Research, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • Department of Oro-Maxillo-Facial Surgery, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • ,
  • László Török, M.D.

      Affiliations

    • Department of Traumatology, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • ,
  • József Kaszaki, Ph.D.

      Affiliations

    • Institute of Surgical Research, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • ,
  • Andrea Szabó, M.D., Ph.D.

      Affiliations

    • Institute of Surgical Research, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • ,
  • Katalin Nagy, M.D., Ph.D.

      Affiliations

    • Department of Oro-Maxillo-Facial Surgery, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • ,
  • Mihály Boros, M.D., Ph.D.

      Affiliations

    • Institute of Surgical Research, Szent-Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Institute of Surgical Research, University of Szeged, Szent-Györgyi Albert Medical and Pharmaceutical Center, Pécsi u. 4., H-6720 Szeged, Hungary.

Received 20 April 2006

References 

  1. Berggren A, Weiland AJ, Ostrup LT, et al. Microvascular free bone transfer with revascularization of the medullary and periosteal circulation or the periosteal circulation alone (A comparative experimental study). J Bone Joint Surg Am. 1982;64:73
  2. Boros M, Takaichi S, Masuda J, et al. Response of mucosal mast cells to intestinal ischemia-reperfusion injury in the rat. Shock. 1995;3:125
  3. Fawcett DW. An experimental study of mast cell degranulation and regeneration. Anat Rec. 1951;121:29
  4. Gaboury JP, Johnston B, Niu XF, et al. Mechanisms underlying acute mast cell-induced leukocyte rolling and adhesion in vivo. J Immunol. 1995;154:804
  5. Thorlacius H, Raud J, Rosengren-Beezley S, et al. Mast cell activation induces P-selectin-dependent leukocyte rolling and adhesion in postcapillary venules in vivo. Biochim Biophys Res Commun. 1994;203:1043
  6. Han B, Tang B, Nimni ME. Combined effects of phosphatidylcholine and demineralized bone matrix on bone induction. Connect Tissue Res. 2003;44:160
  7. Kwak HB, Lee SW, Li YJ, et al. Inhibition of osteoclast differentiation and bone resorption by a novel lysophosphatidylcholine derivative, SCOH. Biochem Pharmacol. 2004;67:1239
  8. Bonucci E, Silvestrini G, Mocetti P. MC22-33F monoclonal antibody shows unmasked polar head groups of choline-containing phospholipids in cartilage and bone. Eur J Histochem. 1997;41:177
  9. Bruhl A, Hafner G, Loffelholz K. Release of choline in the isolated heart, an indicator of ischemic phospholipid degradation and its protection by ischemic preconditioning: No evidence for a role of phospholipase D. Life Sci. 2004;75:1609
  10. Ghyczy M, Torday C, Boros M. Simultaneous generation of methane, carbon dioxide, and carbon monoxide from choline and ascorbic acid: A defensive mechanism against reductive stress?. FASEB J. 2003;17:1124
  11. Duan JM, Karmazyn M. Protection of the reperfused ischemic isolated rat heart by phosphatidylcholine. J Cardiovasc Pharmacol. 1990;15:163
  12. Wolfard A, Csaszar J, Gera L, et al. Endothelin-A receptor antagonist treatment improves the periosteal microcirculation after hindlimb ischemia and reperfusion in the rat. Microcirculation. 2002;9:471
  13. Ruh J, Ryschich E, Secchi A, et al. Measurement of blood flow in the main arteriole of the villi in rat small intestine with FITC-labelled erythrocytes. Microcirc Res. 1998;56:62
  14. Szabo A, Boros M, Kaszaki J, et al. The role of mast cells in mucosal permeability changes during ischemia-reperfusion injury of the small intestine. Shock. 1997;8:284
  15. Kuebler WM, Abels C, Schuerer L, et al. Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc Clin Exp. 1996;16:89
  16. Jones RL, Miller JC, Hagler HK, et al. Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion is cultured rat cardiac myocytes. Am J Path. 1989;135:541
  17. Gross RW. Myocardial phospholipases A2 and their membrane substrates. Trends Cardiovasc Med. 1992;2:115
  18. Lieber CS, Leo MA, Aleynik SI, et al. Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcohol Clin Exp Res. 1997;21:375
  19. Dunjic BS, Axelson J, Ar’Rajab A, et al. Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats. Scand J Gastroenterol. 1993;28:89
  20. Demirbilek S, Aydin G, Yucesan S, et al. Polyunsaturated phosphatidylcholine lowers collagen deposition in a rat model of corrosive esophageal burn. Eur J Pediatr Surg. 2002;12:8
  21. Gabizon A, Meshorer A, Barenholz Y. Comparative long-term study of the toxicities of free and liposome-associated doxorubicin in mice after intravenous administration. J Natl Cancer Inst. 1986;77:459
  22. Yan JJ, Jung JS, Lee JE, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med. 2004;10:161
  23. Cleland LG, Shandling M, Percy JS, et al. Liposomes: A new approach to gold therapy?. J Rheumatol Suppl. 1979;5:154
  24. Exton JH. Regulation of phospholipase D. Biochim Biophys Acta. 1999;1439:121
  25. Hansen HS, Moesgaard B, Hansen HH, et al. N-Acylethanolamines and precursor phospholipids-relation to cell injury. Chem Phys Lipids. 2000;108:35
  26. Friedrich A, George RL, Bridges CC, et al. Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4). Biochim Biophys Acta. 2001;1512:299
  27. Ghyczy M, Boros M. Electrophilic methyl groups present in the diet ameliorate pathological states induced by reductive and oxidative stress: A hypothesis. Br J Nutr. 2001;85:409
  28. Chanavaz M. Anatomy and histophysiology of the periosteum: Quantification of the periosteal blood supply to the adjacent bone with 85Sr and gamma spectrometry. J Oral Implantol. 1995;21:214
  29. Hernandez LA, Grisham MB, Twohig B, et al. Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol. 1987;253:H699
  30. Rucker M, Roesken F, Vollmar B, et al. A novel approach for comparative study of periosteum, muscle, subcutis, and skin microcirculation by intravital fluorescence microscopy. Microvasc Res. 1998;56:30
  31. Eros G, Kaszaki J, Czobel M, et al. Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux. World J Gastroenterol. 2006;12:271
  32. Lindholm RV, Lindholm TS. Mast cells in endosteal and periosteal bone repair (A quantitative study on callus tissue of healing fractures in rabbits). Acta Orthop Scand. 1970;41:129
  33. Saffar JL, Klapisz-Wolikow M. Changes in mast cell number during the activation phase of an induced synchronized remodeling sequence in the rat. Bone. 1990;11:369
  34. Lindholm R, Lindholm S, Liukko P. Fracture healing and mast cells (I. The periosteal callus in rats). Acta Orthop Scand. 1967;38:115
  35. Boros M, Kaszaki J, Nagy S. Oxygen free radical-induced histamine release during intestinal ischemia and reperfusion. Eur Surg Res. 1989;21:297
  36. Kanwar S, Kubes P. Ischemia/reperfusion-induced granulocyte influx is a multistep process mediated by mast cells. Microcirculation. 1994;1:175
  37. Schmeling DJ, Caty MG, Oldham KT, et al. Evidence for neutrophil-related acute lung injury after intestinal ischemia-reperfusion. Surgery. 1989;106:195
  38. Kubes P, Kanwar S. Histamine induces leukocyte rolling in postcapillary venules (A P-selectin-mediated event). J Immunol. 1994;152:3570
  39. Meyer MC, Creer MH, McHowat J. Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. Am J Physiol. 2005;289:C1485
  40. Shpacovitch VM, Varga G, Strey A, et al. Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. J Leukoc Biol. 2004;76:388
  41. Lundberg AH, Fukatsu K, Gaber L, et al. Blocking pulmonary ICAM-1 expression ameliorates lung injury in established diet-induced pancreatitis. Ann Surg. 2001;233:213

PII: S0022-4804(06)00432-X

doi: 10.1016/j.jss.2006.08.004

Journal of Surgical Research
Volume 139, Issue 1 , Pages 45-50 , 1 May 2007

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