Journal of Surgical Research
Volume 139, Issue 1 , Pages 68-76 , 1 May 2007

Loss of Claudin-1 Expression Correlates with Malignancy of Hepatocellular Carcinoma

  • Yukihiro Higashi, M.D.

      Affiliations

    • Second Department of Surgery, Hamamatsu University School of Medicine, Japan
  • ,
  • Shohachi Suzuki, M.D.

      Affiliations

    • Second Department of Surgery, Hamamatsu University School of Medicine, Japan
  • ,
  • Takanori Sakaguchi, M.D.

      Affiliations

    • Second Department of Surgery, Hamamatsu University School of Medicine, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Second Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.
  • ,
  • Toshio Nakamura, M.D.

      Affiliations

    • Second Department of Surgery, Hamamatsu University School of Medicine, Japan
  • ,
  • Satoshi Baba, M.D.

      Affiliations

    • Faculty of Pathology, Hamamatsu University School of Medicine, Japan
  • ,
  • Hans-Christian Reinecker, M.D.

      Affiliations

    • Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts
  • ,
  • Satoshi Nakamura, M.D.

      Affiliations

    • Second Department of Surgery, Hamamatsu University School of Medicine, Japan
  • ,
  • Hiroyuki Konno, M.D.

      Affiliations

    • Second Department of Surgery, Hamamatsu University School of Medicine, Japan

Received 8 May 2006

References 

  1. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991;251:1451
  2. Tsukita S, Furuse M. The structure and function of claudins, cell adhesion molecules at tight junctions. Ann NY Acad Sci. 2000;915:129
  3. Birchmeier C, Birchmeier W, Gherardi E, et al. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 2003;4:915
  4. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2001;2:285
  5. Madara JL. Regulation of the movement of solutes across tight junctions. Annu Rev Physiol. 1998;60:143
  6. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol. 1995;269:G467
  7. Tsukita S, Furuse M. Occludin and claudins in tight-junction strands: leading or supporting players?. Trends Cell Biol. 1999;9:268
  8. Saitou M, Furuse M, Sasaki H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell. 2000;11:4131
  9. Furuse M, Fujita K, Hiiragi T, et al. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998;141:1539
  10. Rahner C, Mitic LL, Anderson JM. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology. 2001;120:411
  11. Furuse M, Hata M, Furuse K, et al. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol. 2002;156:1099
  12. Tsukita S, Furuse M. Claudin-based barrier in simple and stratified cellular sheets. Curr Opin Cell Biol. 2002;14:531
  13. Resnick MB, Konkin T, Routhier J, et al. Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study. Mod Pathol. 2005;18:511
  14. Hoevel T, Macek R, Swisshelm K, et al. Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids. Int J Cancer. 2004;108:374
  15. Kominsky SL, Argani P, Korz D, et al. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene. 2003;22:2021
  16. Miwa N, Furuse M, Tsukita S, et al. Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. Oncol Res. 2000;12:469
  17. Shiozaki H, Tahara H, Oka H, et al. Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol. 1991;139:17
  18. Shimoyama Y, Hirohashi S, Hirano S, et al. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res. 1989;49:2128
  19. Frixen UH, Behrens J, Sachs M, et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol. 1991;113:173
  20. Endo K, Ueda T, Ueyama J, et al. Immunoreactive E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, and patients’ survival. Hum Pathol. 2000;31:558
  21. Osada T, Sakamoto M, Ino Y, et al. E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. Hepatology. 1996;24:1460
  22. Dorudi S, Sheffield JP, Poulsom R, et al. E-cadherin expression in colorectal cancer (An immunocytochemical and in situ hybridization study). Am J Pathol. 1993;142:981
  23. Mayer B, Johnson JP, Leitl F, et al. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res. 1993;53:1690
  24. Moller CJ, Christgau S, Williamson MR, et al. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol. 1992;6:1332
  25. Ihara A, Koizumi H, Hashizume R, et al. Expression of epithelial cadherin and alpha- and beta-catenins in nontumoral livers and hepatocellular carcinomas. Hepatology. 1996;23:1441
  26. Japan, LCSGo. General rules for the clinical and pathological study of primary liver cancer. (ed 4). Tokyo, Japan: Kanehara Press; 2000;
  27. Nagao T, Inoue S, Yoshimi F, et al. Postoperative recurrence of hepatocellular carcinoma. Ann Surg. 1990;211:28
  28. Fukuda S, Itamoto T, Nakahara H, et al. Clinicopathologic features and prognostic factors of resected solitary small-sized hepatocellular carcinoma. Hepatogastroenterology. 2005;52:1163
  29. Sakaguchi T, Gu X, Golden HM, et al. Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem. 2002;277:21361
  30. Nuruki K, Toyoyama H, Ueno S, et al. E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas. Oncol Rep. 1998;5:1109
  31. Chen Y, Lu Q, Schneeberger EE, et al. Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell. 2000;11:849
  32. Zavadil J, Bottinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene. 2005;24:5764
  33. Oft M, Heider KH, Beug H. TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol. 1998;8:1243
  34. Ozdamar B, Bose R, Barrios-Rodiles M, et al. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science. 2005;307:1603
  35. Gao L, Joberty G, Macara IG. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol. 2002;12:221
  36. Michl P, Buchholz M, Rolke M, et al. Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology. 2001;121:678
  37. de Oliveira SS, de Oliveira IM, De Souza W, et al. Claudins upregulation in human colorectal cancer. FEBS Lett. 2005;579:6179

PII: S0022-4804(06)00484-7

doi: 10.1016/j.jss.2006.08.038

Journal of Surgical Research
Volume 139, Issue 1 , Pages 68-76 , 1 May 2007