Journal of Surgical Research
Volume 139, Issue 1 , Pages 7-14 , 1 May 2007

The Effect of Antagonism of Adenosine A1 Receptor Against Ischemia and Reperfusion Injury of the Liver

  • Shinichiro Magata, M.D.

      Affiliations

    • Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Hokkaido University, Hokkaido, Japan.
    • ,
  • Masahiko Taniguchi, M.D.

      Affiliations

    • Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Tomomi Suzuki, M.D.

      Affiliations

    • Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Tsuyoshi Shimamura, M.D.

      Affiliations

    • Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Moto Fukai, M.D.

      Affiliations

    • Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Hiroyuki Furukawa, M.D.

      Affiliations

    • Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Miri Fujita, M.D.

      Affiliations

    • Department of Pathology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Satoru Todo, M.D.

      Affiliations

    • Department of Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Received 11 November 2005

References 

  1. Bouma MG, Van den Wildenberg FAJM, Buurman WA. The anti-inflammatory potential of adenosine ischemia-reperfusion injury: established and putative beneficial actions of a retaliatory metabolism. Shock. 1997;8:313
  2. Forman MB, Velasco CE, Jackson EK. Adenosine attenuates reperfusion injury following regional myocardial ischemia. Cardiovasc Res. 1993;27:9
  3. Kitakaze M, Hori M, Kameda T. Role of adenosine and its interaction with α adrenoceptor activity in ischaemic and reperfusion injury of the myocardium. Cardiovasc Res. 1993;27:18
  4. Peralta C, Hotter G, Closa D, et al. The protective role of adenosine in inducing nitric oxide synthesis in rat liver ischemia preconditioning is mediated by activation of adenosine A2 receptors. Hepatology. 1999;29:126
  5. Nakayama H, Yamamoto Y, Kume M, et al. Pharmacologic stimulation of adenosine A2 receptor supplants ischemic preconditioning in providing ischemic tolerance in rat livers. Surgery. 1999;126:945
  6. Arai M, Thurman RG, Lemasters JJ. Contribution of adenosine A (2) receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against storage/reperfusion injury in rat livers. Hepatology. 2000;32:297
  7. Taniguchi M, Magata S, Suzuki T, et al. S. Dipyridamole protects the liver against warm ischemia and reperfusion injury. J Am Coll Surg. 2004;198:758
  8. Todo S, Zhu Y, Zhang S, et al. Attenuation of ischemic liver injury by augmentation of endogenous adenosine. Transplantation. 1997;63:217
  9. Neely CF, Keith IM. A1 adenosine receptor antagonists block ischemia-reperfusion injury of the lung. Am J Physiol. 1995;268:L1036
  10. Zahler S, Becker BF, Raschke P, et al. Stimulation of endothelial adenosine A1 receptors enhances adhesion of neutrophils in the intact guinea pig coronary system. Cardiovasc Res. 1994;28:1366
  11. Zhang S, Jin MB, Zhu Y, et al. Effect of endogenous adenosine augmentation on ischemia and reperfusion injury of the liver. Transplant Proc. 1997;29:1336
  12. Ely SW, Berne RM. Protective effects of adenosine in myocardial ischemia. Circulation. 1992;85:893
  13. Olsson RA, Pearson JD. Cardiovascular purinoreceptors. Physiol Rev. 1990;70:761
  14. Fredholm BB, Abbracchio MP, Burnstock G, et al. Nomenclature and classification of purinoceptors. Pharmacol Rev. 1994;46:143
  15. Peralta C, Hotter G, Closa D, et al. Protective effect of preconditioning on the injury associated to hepatic ischemia-reperfusion in the rat: Role of nitric oxide and adenosine. Hepatology. 1997;25:934
  16. Cristalli G, Vittori S, Thompson RD, et al. Inhibition of platelet aggregation by adenosine receptor agonists. Arch Pharmacol. 1994;349:644
  17. Cronstein BN, Levin RI, Philips M, et al. The adenosine/neutrophil paradox resolved: Human neutrophils possess both A1 and A2 receptor that promote chemotaxis and inhibit O2− generation, respectively. J Clin Invest. 1990;85:1150
  18. Prabhakar U, Brooks DP, Lipshilitz D, et al. Inhibition of LPS-induced TNFα production in human monocytes by adenosine (A2) receptor selective agonists. Int J Immunopharmacol. 1995;17:221
  19. Minamino T, Kitakaze M, Asanuma H, et al. Endogenous adenosine inhibits P-selectin-dependent-formation of coronary thromboemboli during hypoperfusion in dogs. J Clin Invest. 1998;101:1643
  20. Nonaka H, Ichimura M, Takeda M, et al. KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br J Pharm. 1996;117:1645
  21. Wynants J, van Belle H. Single-run high-performance liquid chromatography of nucleotides, nucleosides, and major purine bases and its application to different tissue extracts. Anal Biochem. 1985;144:258
  22. Atkinson DE. The energy charge of the adenylate pool as a regulatory parameter, interaction with feed back modifiers. Biochemistry. 1968;7:4030
  23. Suzuki S, Pereyra T, Dodriguez FJ. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Transplantation. 1993;55:1265
  24. Totsuka E, Todo S, Zhu Y, et al. Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483. J Am Coll Surg. 1998;187:276
  25. Drury AN, Szent-Gyorgy A. The physiological activity of adenine compounds with special reference to their actions upon the mammalian heart. J Physiol. 1929;68:213
  26. Van Belle H, Goossens F, Wynants J. Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia. Am J Physiol. 1987;252(5 Pt 2):H886
  27. Abbracchio MP, Cattaberi F, Fredholm BB, et al. Purinorecetor nomenclature: A status report. Drug Dev Res. 1993;28:207
  28. Dixon AK, Gubitz AK, Sirinathsinghji DJ, et al. Tissue distribution of adenosine receptor mRNAs in the rat. Br J Pharmacol. 1996;118:1461
  29. Liu GS, Thornton J, Van Winkle D, et al. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation. 1991;84:350
  30. Downey JM. Ischemic preconditioning: Nature’s own cardioprotective intervention. Trend Cardiovasc Med. 1992;2:170
  31. Collis MG, Hourani SMO. Adenosine receptor subtypes. Trends Pharmacol Sci. 1993;14:360
  32. Barrett RJ, Droppleman DA. Interaction of adenosine A1 receptor mediated renal vasoconstriction of endogenous nitric oxide and ANGII. Am J Physiol. 1993;265:F651
  33. Guinzberg R, Diaz-Cruz A, Uribe S, et al. Ca2+ dependence of the response of three adenosine type receptors in rat hepatocytes. Eur J Pharmacol. 1997;340:243
  34. Takemura S, Kawada N, Hirohashi K, et al. Nucleotide receptors in hepatic stellate cells of the rat. FEBS Lett. 1994;354:53
  35. Hayslett JP, Macala LJ, Smallwood JI, et al. Adenosine stimulation of Na+ transport is mediated by an A1 receptor and a [Ca2+]i-dependent mechanism. Kidney Int. 1995;47:1576
  36. Wollner A, Wollner S, Smith JB. Acting via A2 receptors, adenosine inhibits the up regulation of Mac-1 (CD11b/CD18) expression of FMLP-stimulated neutrophils. Am J Respir Cell Mol Biol. 1993;9:179
  37. Harada N, Okajima K, Murakami K, et al. Adenosine and selective A (2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation. J Pharmacol Exp Ther. 2000;294:1034
  38. Li J, Fenton RA, Wheeler HB, et al. Adenosine A2a receptors increase atrial endothelial cell nitric oxide. 1998;80:357
  39. Aki Y, Tomohiro A, Nishiyama A, et al. Effective of KW3902, a selective and potent adenosine A1 receptor antagonist, on renal hemodynamics and urine formation in anesthetized dogs. Pharmacology. 1997;55:193
  40. Zhao Z-Q, Nakanishi K, McGee DS, et al. A1 receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischemia. Cardiovasc Res. 1994;28:270
  41. Mizumoto H, Karasawa A, Kubo K. Diuretic and renal protective effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist, via pertussis toxin insensitive mechanism. J Pharmacol Exp Ther. 1993;266:200
  42. Fredholm BB, Jacobson KA, Jonzon B, et al. Evidence that a novel 8-phenyl-substituted xanthine derivative is a cardioselective adenosine receptor antagonist in vivo. J Cardiovasc Pharmacol. 1987;9:396
  43. Schanne FA, Kane AB, Young EE, et al. Calcium dependence of toxic cell death (A final common pathway). Science. 1979;206:700
  44. Nakano H, Monden M, Umeshita K, et al. Cytoprotective effect of prostaglandin I2 analogues on superoxide-induced hepatocyte injury. Surgery. 1994;116:883
  45. Urakami A, Todo S, Zhu Y, et al. Attenuation of ischemia liver injury by monoclonal anti-endothelin antibody, AwETN40. J Am Coll Surg. 1997;185:358
  46. Minami K, Fukuzawa K, Nakaya Y, et al. Mechanism of activation of the Ca2+-activated K+ channel by cyclic AMP in cultured porcine coronary artery smooth muscle cells. Life Sci. 1993;53:1129
  47. Nieri P, Martinotti E, Calderone V, et al. Adenosine-mediated hypotension in vivo guinea pig: Receptors involved and role of NO. Br J Pharmacol. 2001;134:745
  48. Nie Z, Mei Y, Ford M, et al. Oxidative stress increases A1 adenosine receptor expression by acting nuclear factor κB. Mol Pharmacol. 1998;53:663
  49. Cronstein BN, Rosenstein ED, Kramer SB, et al. Adenosine: A physiologic modulator of superoxide anion generation by human neutrophils (Adenosine acts via an A1 receptor on human neutrophils). J Immunol. 1985;135:1366
  50. Adkins WK, Barnard JW, May S, et al. Compounds that increase cyclic AMP prevent ischemia-reperfusion pulmonary capillary injury. J Appl Physiol. 1992;72:492
  51. Tomita I, Sawa M, Munakata T, et al. The beneficial effect of dibutyryl cyclic adenosine monophosphate on warm ischemic injury of the rat liver induced by cardiac arrest. Transplantation. 1996;62:167

PII: S0022-4804(06)00496-3

doi: 10.1016/j.jss.2006.09.021

Journal of Surgical Research
Volume 139, Issue 1 , Pages 7-14 , 1 May 2007

Article Tools

* Image Usage & Resolution