Journal of Surgical Research
Volume 139, Issue 1 , Pages 15-21 , 1 May 2007

Does Impaired Th1/Th2 Balance Cause Postoperative Infectious Complications in Colorectal Cancer Surgery?

Received 31 March 2006

References 

  1. Faist E, Kupper TS, Baker CC, et al. Depression of cellular immunity after major injury (Its association with posttraumatic complications and its reversal with immunomodulation). Arch Surg. 1986;121:1000
  2. Salo M. Effects of anaesthesia and surgery on the immune response. Acta Anaesthesiol Scand. 1992;36:201
  3. Lundy J, Lovett EJ, Wolinsky SM, et al. Immune impairment and metastatic tumor growth: the need for an immunorestorative drug as an adjunct to surgery. Cancer. 1979;43:945
  4. Christou NV, Meakins JL, Gordon J, et al. The delayed hypersensitivity response and host resistance in surgical patients (20 years later). Ann Surg. 1995;222:534
  5. Del Prete G, Maggi E, Romagnani S. Human Th1 and Th2 cells: functional properties, mechanisms of regulation, and role in disease. Lab Invest. 1994;70:299
  6. Romagnani S. The Th1/Th2 paradigm. Immunol Today. 1997;18:263
  7. Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone (I. Definition according to profiles of lymphokine activities and secreted proteins). J Immunol. 1986;136:2348
  8. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today. 1996;17:138
  9. Manetti R, Gerosa F, Giudizi MG, et al. Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J Exp Med. 1994;179:1273
  10. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol. 1994;12:227
  11. Faist E, Schinkel C, Zimmer S. Update on the mechanisms of immune suppression of injury and immune modulation. World J Surg. 1996;20:454
  12. Decker D, Schondorf M, Bidlingmaier F, et al. Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Surgery. 1996;119:316
  13. Tabata T, Hazama S, Yoshino S, et al. Th2 subset dominance among peripheral blood T lymphocytes in patients with digestive cancers. Am J Surg. 1999;177:203
  14. Ishikawa M, Nishioka M, Hanaki N, et al. Hepatic resection induces a shift in the Th 1/2 balance toward Th 2 and produces hypermetabolic and hyperhemodynamic states. Hepatogastroenterology. 2004;51:1422
  15. Openshaw P, Murphy EE, Hosken NA, et al. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med. 1995;182:1357
  16. Schauer U, Jung T, Krug N, et al. Measurement of intracellular cytokines. Immunol Today. 1996;17:305
  17. Picker LJ, Singh MK, Zdraveski Z, et al. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood. 1995;86:1408
  18. Crucian B, Dunne P, Friedman H, et al. Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection by flow cytometry and surface marker analysis. Clin Diagn Lab Immunol. 1996;3:411
  19. Pollock RE, Lotzova E, Stanford SD. Surgical stress impairs natural killer cell programming of tumor for lysis in patients with sarcomas and other solid tumors. Cancer. 1992;70:2192
  20. Roy MC, Perl TM. Basics of surgical-site infection surveillance. Infect Control Hosp Epidemiol. 1997;18:659
  21. Delgado-Rodriguez M, Gomez-Ortega A, Llorca J, et al. Nosocomial infection, indices of intrinsic infection risk, and in-hospital mortality in general surgery. J Hosp Infect. 1999;41:203
  22. Stone HH, Hooper CA, Kolb LD, et al. Antibiotic prophylaxis in gastric, biliary and colonic surgery. Ann Surg. 1976;184:443
  23. Cruse PJ, Foord R. The epidemiology of wound infection (A 10-year prospective study of 62,939 wounds). Surg Clin North Am. 1980;60:27
  24. Tang R, Chen HH, Wang YL, et al. Risk factors for surgical site infection after elective resection of the colon and rectum: a single-center prospective study of 2,809 consecutive patients. Ann Surg. 2001;234:181
  25. Ford CD, VanMoorleghem G, Menlove RL. Blood transfusions and postoperative wound infection. Surgery. 1993;113:603
  26. Kingston RD, Walsh S, Robinson C, et al. Significant risk factors in elective colorectal surgery. Ann R Coll Surg Engl. 1995;77:369
  27. Miki C, Inoue Y, Toiyama Y, et al. Deficiency in systemic interleukin-1 receptor antagonist production as an operative risk factor in malnourished elderly patients with colorectal carcinoma. Crit Care Med. 2005;33:177
  28. Heriot AG, Marriott JB, Cookson S, et al. Reduction in cytokine production in colorectal cancer patients: Association with stage and reversal by resection. Br J Cancer. 2000;82:1009
  29. Allen JE, Maizels RM. Th1-Th2: reliable paradigm or dangerous dogma?. Immunol Today. 1997;18:387
  30. Ishikawa M, Nishioka M, Hanaki N, et al. Hepatic resection leads to predominance of the T helper-2 lymphocyte phenotype. Hepatol Res. 2004;30:96
  31. Davis EG, Eichenberger MR, Grant BS, et al. Microsatellite marker of interferon-gamma receptor 1 gene correlates with infection following major trauma. Surgery. 2000;128:301
  32. van Sandick JW, Gisbertz SS, ten Berge IJ, et al. Immune responses and prediction of major infection in patients undergoing transhiatal or transthoracic esophagectomy for cancer. Ann Surg. 2003;237:35
  33. Pala P, Hussell T, Openshaw PJ. Flow cytometric measurement of intracellular cytokines. J Immunol Methods. 2000;243:107
  34. Whiteside TL. Cytokine assays. Biotechniques. 2002;33(Suppl):4
  35. Jung T, Schauer U, Heusser C, et al. Detection of intracellular cytokines by flow cytometry. J Immunol Methods. 1993;159:197
  36. Prussin C. Cytokine flow cytometry: Understanding cytokine biology at the single-cell level. J Clin Immunol. 1997;17:195

PII: S0022-4804(06)00562-2

doi: 10.1016/j.jss.2006.10.029

Journal of Surgical Research
Volume 139, Issue 1 , Pages 15-21 , 1 May 2007

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