Journal of Surgical Research
Volume 142, Issue 1 , Pages 66-71 , September 2007

Mesenteric Lymph Node Tγδ Cells Induced by Gastrectomy in Mice Suppress Cell-Mediated Immune Response In Vitro via Released TGF-β

  • Andrzej Gryglewski, M.D., Ph.D.

      Affiliations

    • Department of Anatomy, Jagiellonian University College of Medicine, Kraków, Poland
    • ,
  • Pawel Majcher, Ph.D.

      Affiliations

    • Department of Human Developmental Biology, Jagiellonian University College of Medicine, Kraków, Poland
    • ,
  • Krzysztof Bryniarski, Ph.D.

      Affiliations

    • Department of Immunology, Jagiellonian University College of Medicine, Kraków, Poland
    • ,
  • Stanislaw Konturek, M.D., Ph.D.

      Affiliations

    • Department of Physiology, Jagiellonian University College of Medicine, Kraków, Poland
    • ,
  • Maria Ptak, Ph.D.

      Affiliations

    • Department of Immunology, Jagiellonian University College of Medicine, Kraków, Poland
    • ,
  • Wlodzimierz Ptak, M.D., Ph.D.

      Affiliations

    • Department of Immunology, Jagiellonian University College of Medicine, Kraków, Poland
    • ,
  • Marian Szczepanik, Ph.D.

      Affiliations

    • Department of Human Developmental Biology, Jagiellonian University College of Medicine, Kraków, Poland
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Human Developmental Biology, Jagiellonian University College of Medicine, ul. Kopernika 7, 31-034 Kraków, Poland.

Received 29 May 2006

References 

  1. Green DR, Marcotte R, Wang N. The role of inhibitory cells in burn trauma-associated immunodeficiency. In:  Raist E,  Ninnemann J,  Green D editor. Immune consequences of trauma, shock, and sepsis. Berlin/New York: Springer-Verlag; 1989;p. 56
  2. Chaudry IH, Ayala A. Immunological aspects of hemorrhage. In: Austin: Medical Intelligence Unit, RG Landes Company; 1992;p. 1
  3. Stephan RN, Ayala A, Chaudry IH. Monocyte and lymphocyte responses following trauma. In:  Schlag G,  Redl H editor. Pathophysiology of shock, sepsis, and organ failure. Berlin: Springer-Verlag; 1993;p. 131
  4. Roumen RM, Hendriks T, van der Ven-Jongekrijg J, et al. Cytokine patterns in patients after major surgery, hemorrhagic shock, and severe blunt trauma. Ann Surg. 1993;6:769
  5. Faist E, Baue AE, Dittmer H. Multiple organ failure in polytrauma patients. J Trauma. 1983;23:775
  6. Angele MK, Faist E. Clinical review: Immunodepression in the surgical patient and increased susceptibility to infection. Crit Care. 2002;6:298
  7. Gasz B, Lenard L, Benko L, et al. Expression of CD97 and adhesion molecules on circulating leukocytes in patients undergoing coronary artery bypass surgery. Eur Surg Res. 2005;37:281
  8. Gryglewski A, Szczepanik M, Majcher P, et al. Different patterns of gdT and αβT cell redistribution in the mouse after partial gastrectomy. J Surg Res. 1997;73:137
  9. Mc Kinney M, Parkinson AA. Single nonchromatographic procedure to purify immunoglobulins from serum and ascites. J Immunol Methods. 1987;96:271
  10. Little JR, Eisen HN. Preparation and characterization of antibodies specific for the 2, 4, 6-trinitro group. Biochemistry. 1966;5:3385
  11. Tsuji RF, Szczepanik M, Kavikowa I, et al. B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity. J Exp Med. 2002;196:1277
  12. Szczepanik M, Bryniarski K, Tutaj M, et al. Epicutaneous immunization induces αβT-cell receptor CD4 CD8 double-positive nonspecific suppressor T cells that inhibit contact sensitivity via transforming growth factor-β. Immunology. 2005;115:42
  13. Gryglewski A, Popiela T, Ptak W. Effects of surgical trauma (gastrectomy) on cell-mediated and humoral responses in mice. Clin Exp Immunol. 1985;59:50
  14. Faria AM, Weiner HL. Oral tolerance. Immunol Rev. 2005;206:232
  15. Ptak W, Szczepanik M, Bryniarski K, et al. Cross-reactivity of TNP and immune effector T cells that mediate contact hypersensitivity and inflammatory bowel disease in the mouse. Int Arch Allergy Immunol. 2000;123:333
  16. Kabelitz D, Marischen L, Oberg HH, et al. Epithelial defense by γδT cells. Int Arch Allergy Immunol. 2005;137:333
  17. Holtmeier W. Compartmentalization γδT cells and their putative role in mucosal immunity. Crit Rev Immunol. 2003;23:473
  18. Green DR, Ptak W. Contrasuppression in the mouse. Immunol Today. 1986;7:81
  19. Suzuki I, Kiyono H, Kitamura K, et al. Abrogation of oral tolerance by contrasuppressor T cells suggests the presence of regulatory T cell networks in the mucosal immune system. Nat Immunol. 1986;320:451
  20. Hayday A, Tigelaar R. Immunoregulation in tissues by γδT cells. Nat Rev Immunol. 2003;3:233
  21. Schäffer M, Barbul A. Lymphocyte function in wound healing and following injury. Brit J Surg. 1998;85:444
  22. Meert KL, Ofenstein JP, Genyea C, et al. Elevated transforming growth factor-β concentration correlates with post-trauma immunosuppression. Arch Surg. 1996;40:901
  23. Miller-Graziano CL, Szabo G, Griffey K, et al. Role of elevated monocyte transforming growth factor-β (TGF-β) production in post-trauma immunosuppression. J Clin Immunol. 1991;11:95
  24. Chantry D, Turner M, Abney E, et al. Modulation of cytokine production by transforming growth factor-β. J Immunol. 1989;147:4295
  25. Postlethwaite AE, Keski-Oja J, Moses HL, et al. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor β. J Exp Med. 1987;165:251
  26. Roberts AB, Sporn MB, Assoian RK, et al. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U.S.A. 1986;83:4167

PII: S0022-4804(06)00587-7

doi: 10.1016/j.jss.2006.10.050

Journal of Surgical Research
Volume 142, Issue 1 , Pages 66-71 , September 2007

Article Tools

* Image Usage & Resolution