Journal of Surgical Research
Volume 140, Issue 1 , Pages 36-44 , 1 June 2007

Increased Leukotriene C4 Synthesis Accompanied Enhanced Leukotriene C4 Synthase Expression and Activities of Ischemia–Reperfusion-Injured Liver in Rats

Received 10 July 2006

References 

  1. Cutrn JC, Perrelli MG, Cavalieri B, et al. Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning. Free Radic Biol Med. 2002;33:1200
  2. Serracino-Inglott F, Virlos IT, Habib NA, et al. Differential nitric oxide synthase expression during hepatic ischemia-reperfusion. Am J Surg. 2003;185:589
  3. Hur GM, Ryu YS, Yun HY, et al. Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-kappaB. Biochem Biophys Res Commun. 1999;261:917
  4. Kawachi S, Hines IN, Laroux FS, et al. Nitric oxide synthase and postischemic liver injury. Biochem Biophys Res Commun. 2000;276:851
  5. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg. 2001;181:160
  6. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol. 2003;284:G15
  7. Jaeschke H, Farhood A. Kupffer cell activation after no-flow ischemia versus hemorrhagic shock. Free Radic Biol Med. 2002;33:210
  8. Uehara N, Ormstad K, Orning L, et al. Characteristics of the uptake of cysteine-containing leukotrienes by isolated hepatocytes. Biochim Biophys Acta. 1983;732:69
  9. Farzaneh-Far R, Moore K. Cysteinyl-leukotrienes and the liver. Prostaglandins Other Lipid Mediat. 2003;72:35
  10. Henderson WR. The role of leukotrienes in inflammation. Ann Intern Med. 1994;121:684
  11. Lam BK. Leukotriene C (4) synthase. Prostaglandins Leukot Essent Fatty Acids. 2003;69:111
  12. Jakobsson PJ, Mancini JA, Riendeau D, et al. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. J Biol Chem. 1997;272:22934
  13. Jakobsson PJ, Mancini JA, Ford-Hutchinson AW. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. J Biol Chem. 1996;271:22203
  14. Samuelsson B, Dahlen SE, Lindgren JA, et al. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science. 1987;237:1171–1176
  15. Lam BK, Frank Austen K. Leukotriene C4 synthase (A pivotal enzyme in the biosynthesis of the cysteinyl leukotrienes). Am J Respir Crit Care Med. 2000;161:S16
  16. Matuschak GM, Henry KA, Johanns CA, et al. Liver-lung interactions following Escherichia coli bacteremic sepsis and secondary hepatic ischemia/reperfusion injury. Am J Respir Crit Care Med. 2001;163:1002
  17. Rao AM, Hatcher JF, Kindy MS, et al. Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. Neurochem Res. 1999;24:1225
  18. Eppihimer MJ, Russell J, Anderson DC, et al. Modulation of P-selectin expression in the postischemic intestinal microvasculature. Am J Physiol. 1997;273:G1326
  19. Takase B, Kurita A, Maruyama T, et al. Change of plasma leukotriene C4 during myocardial ischemia in humans. Clin Cardiol. 1996;19:198
  20. Abonia JP, Friend DS, Austen WG, et al. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol. 2005;174:7285
  21. Quiroga J, Prieto J. Liver cytoprotection by prostaglandins. Pharmacol Ther. 1993;58:67
  22. Sinclair S, Levy G. Eicosanoids and the liver. Ital J Gastroenterol. 1990;22:205
  23. Wettstein M, Haussinger D. [Effect of hypoxia on nitric oxide formation and leukotriene metabolism in the perfused rat liver]. Zentralbl Chir. 1994;119:328
  24. Cavalieri B, Perrelli MG, Aragno M, et al. Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver. Cell Biochem Funct. 2003;21:299
  25. Post S, Palma P, Gonzalez AP, et al. Role of eicosanoids in reperfusion injury in rat liver transplantation (Transplant). Proc. 1993;25:2547
  26. Takamatsu Y, Shimada K, Chijiiwa K, et al. Role of leukotrienes on hepatic ischemia/reperfusion injury in rats. J Surg Res. 2004;119:14
  27. Schroder O, Sjostrom M, Qiu H, et al. Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. Cell Mol Life Sci. 2005;62:87
  28. Denzlinger C, Guhlmann A, Scheuber SPH, et al. Metabolism and analysis of cysteinyl leukotrienes in the monkey. J Biol Chem. 1986;261:15601
  29. Shimada K, Navarro J, Goeger DE, et al. Expression and regulation of leukotriene-synthesis enzymes in rat liver cells. Hepatology. 1998;28:1275
  30. Sjolinder M, Stenke L, Nasman-Glaser B, et al. Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia. Blood. 2000;95:1456
  31. Gonzalez J, Cienfuegos JA, Pardo F, et al. Leukotriene C4 detection as an early graft function marker in liver transplantation. Transplant Proc. 1992;24:135
  32. Gonzalez J, Cienfuegos JA, Pardo F, et al. Role of leukotrienes B4 and C4 in liver allograft rejection. Transpl Int. 1992;5(Suppl 1):S659
  33. Tiegs G, Wolter M, Wendel A. Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol. 1989;38:627
  34. Wendel A, Tiegs G, Werner C. Evidence for the involvement of a reperfusion injury in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol. 1987;36:2637
  35. Gulluoglu BM, Aktan AO, Yegen C, et al. Endothelin release is augmented with captopril in rat ischemia-reperfusion injury of the liver. Res Exp Med (Berl). 1996;196:227
  36. Gut J, Costa AK, Trudell JR. Oxygen concentration-dependent metabolism of leukotriene B4 by hepatocyte monolayers. Biochim Biophys Acta. 1986;878:194
  37. Hughes H, Farhood A, Jaeschke H. Role of leukotriene B4 in the pathogenesis of hepatic ischemia-reperfusion injury in the rat. Prostaglandins Leukot Essent Fatty Acids. 1992;45:113
  38. Miyagi S, Ohkohchi N, Oikawa K, et al. Effects of anti-inflammatory cytokine agent (FR167653) and serine protease inhibitor on warm ischemia-reperfusion injury of the liver graft. Transplantation. 2004;77:1487
  39. Nakamaru K, Sugai T, Kinoshita N, et al. [Effect of mesalazine, an agent for the treatment of idiopathic inflammatory bowel disease, on reactive oxygen metabolites and LTB4 formation]. Nippon Yakurigaku Zasshi. 1994;104:447
  40. Okboy N, Yegen C, Aktan AO, et al. The effect of iloprost and NDGA in ischemia reperfusion injury in rat liver. Prostaglandins Leukot Essent Fatty Acids. 1992;47:291
  41. Lam BK, Penrose JF, Xu K, et al. Site-directed mutagenesis of human leukotriene C4 synthase. J Biol Chem. 1997;272:13923
  42. Sjostrom M, Jakobsson PJ, Heimburger M, et al. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. Eur J Biochem. 2001;268:2578
  43. Scoggan KA, Jakobsson PJ, Ford-Hutchinson AW. Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. J Biol Chem. 1997;272:10182
  44. Kanaoka Y, Maekawa A, Penrose JF, et al. Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. J Biol Chem. 2001;276:22608
  45. Jaeschke H. Mechanisms of reperfusion injury after warm ischemia of the liver. J Hepatobiliary Pancreat Surg. 1998;5:402
  46. Jaeschke H, Schini VB, Farhood A. Role of nitric oxide in the oxidant stress during ischemia/reperfusion injury of the liver. Life Sci. 1992;50:1797
  47. Reid GK, Kargman S, Vickers PJ, et al. Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis. J Biol Chem. 1990;265:19818
  48. Fukai FS, Nishizawa Y, Katayama T. Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. Cell Biol Int. 1996;20:423
  49. Satoh S, Uetake S, Ohata M, et al. [Effect of type of dietary fat and ethanol on hepatic leukotriene level in experimental alcoholic liver disease]. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2003;38:350
  50. Koken T, Inal M. The effect of nitric oxide on ischemia-reperfusion injury in rat liver. Clin Chim Acta. 1999;288:55
  51. Keppler D, Jedlitschky G, Leier I. Transport and metabolism of leukotrienes. Adv Prostaglandin Thromboxane Leukot Res. 1994;22:83
  52. Makogon NV, Korneitchuk AN, Lushnikova IV, et al. Effects of exogenous leukotrienes B4 and C4 on the viability of cultured rat hepatocytes. Acta Physiol Pharmacol Bulg. 2000;25:87

PII: S0022-4804(06)00595-6

doi: 10.1016/j.jss.2006.11.009

Journal of Surgical Research
Volume 140, Issue 1 , Pages 36-44 , 1 June 2007