Journal of Surgical Research
Volume 141, Issue 2 , Pages 192-195 , August 2007

MF-Tricyclic Inhibits Growth of Experimental Abdominal Aortic Aneurysms

  • W. Brent Keeling, M.D.

      Affiliations

    • University of South Florida Division of Vascular and Endovascular Surgery, Tampa, Florida
    • ,
  • Amy E. Hackmann, M.D.

      Affiliations

    • University of South Florida Division of Vascular and Endovascular Surgery, Tampa, Florida
    • ,
  • Mary E. Colter, Ph.D.

      Affiliations

    • H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
    • ,
  • Patrick A. Stone, M.D.

      Affiliations

    • University of South Florida Division of Vascular and Endovascular Surgery, Tampa, Florida
    • ,
  • Brad L. Johnson, M.D.

      Affiliations

    • University of South Florida Division of Vascular and Endovascular Surgery, Tampa, Florida
    • ,
  • Martin R. Back, M.D.

      Affiliations

    • University of South Florida Division of Vascular and Endovascular Surgery, Tampa, Florida
    • ,
  • Dennis F. Bandyk, M.D.

      Affiliations

    • University of South Florida Division of Vascular and Endovascular Surgery, Tampa, Florida
    • ,
  • Murray L. Shames, M.D.

      Affiliations

    • University of South Florida Division of Vascular and Endovascular Surgery, Tampa, Florida
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at University of South Florida, Vascular and Endovascular Surgery, 4 Columbia Drive, Suite 650, Tampa, FL 33606.

Received 14 June 2006

References 

  1. Melton LJ, Bickerstaff LK, Hollier LH, et al. Changing incidence of abdominal aortic aneurysms: A population-based study. Am J Epidemiol. 1984;120:379
  2. Bickerstaff LK, Hollier LH, Van Peenen HJ, et al. Abdominal aortic aneurysms: The changing natural history. J Vasc Surg. 1984;1:6
  3. Tung WS, Lee JK, Thompson RW. Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array. J Vasc Surg. 2001;34:143
  4. Lindholt JS, Vammen S, Fasting H, et al. The plasma level of matrix metalloproteinase 9 may predict the natural history of small abdominal aortic aneurysms (A preliminary study). Eur J Vasc Endovasc Surg. 2000;20:281
  5. Pyo R, Lee JK, Shipley JM, et al. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest. 2000;105:1641
  6. Corcoran ML, Stetler-Stevenson WG, DeWitt DL, et al. Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes. Arch Biochem Biophys. 1994;310:481
  7. Miralles M, Wester W, Sicard GA, et al. Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase. J Vasc Surg. 1999;29:884;; discussion 892.
  8. Seibert K, Masferrer JL. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor. 1994;4:17
  9. Masferrer JL, Zweifel BS, Manning PT, et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA. 1994;12(91):3228
  10. van Ryn J, Pairet M. Selective cyclooxygenase-2 inhibitors: Pharmacology, clinical effects and therapeutic potential. Exp Opin Investig Drugs. 1997;6:609
  11. Caldwell B, Aldington S, Weatherall M, et al. Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis. J R Soc Med. 2006;99:132
  12. Hetu PO, Riendeau D. Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain. Biochem. J. 2005;391:561
  13. Baxter BT, Pearce WH, Waltke EA, et al. Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study. J Vasc Surg. 2002;36:1
  14. King VL, Trivedi D, Gitlin JM, et al. Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler Thromb Vasc Biol 2006 [Epub ahead of print].
  15. Armstrong PJ, Franklin DP, Carey DJ, et al. Suppression of experimental aortic aneurysms: Comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors. Ann Vasc Surg. 2005;19:248

PII: S0022-4804(06)01160-7

doi: 10.1016/j.jss.2006.12.544

Journal of Surgical Research
Volume 141, Issue 2 , Pages 192-195 , August 2007

Article Tools

* Image Usage & Resolution