Journal of Surgical Research
Volume 142, Issue 2 , Pages 219-226 , October 2007

The HDAC Inhibitor Trichostatin A Inhibits Growth of Small Cell Lung Cancer Cells

Received 13 September 2006

References 

  1. Cancer Facts and Figures 2006 (American Cancer Society). Atlanta: American Cancer Society; 2006;
  2. Spiro SG, Silvestri GA. One hundred years of lung cancer. Am J Respir Crit Care Med. 2005;172:523
  3. Spiro SG, Porter JC. Lung Cancer—Where are we today? (Current advances in staging and nonsurgical treatment). Am J Respir Crit Care Med. 2002;166:1166
  4. Kunnimalaiyaan M, Chen H. The Raf-1 pathway: A molecular target for treatment of select neuroendocrine tumors?. Anticancer Drugs. 2006;17:139
  5. Lewiński T, Żuławki M, Czesław T, et al. Small cell lung cancer I-III A: Cytoreductive chemotherapy followed by resection with continuation of chemotherapy. Eur J Cardiothorac Surg. 2001;20:391
  6. Sattler M, Salgia R. Molecular and cellular biology of small cell lung cancer. Semin Oncol. 2003;30:57
  7. Greco FA, Saijo N. Current perspectives in the treatment of small cell lung cancer—Introduction. Semin Oncol. 2001;28:1
  8. Chen H, Thiagalingam A, Chopra H, et al. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci USA. 1997;94:5355
  9. Tao L, Kuljaca S, Tee A, et al. Histone deacetylase inhibitors: Multifunctional anticancer agents. Cancer Treat Rev. 2006;32:157
  10. Karagiannis TC, El-Osta A. Modulation of Cellular radiation responses by histone deacetylase inhibitors. Oncogene. 2006;25:3885
  11. Shao Y, Gao Z, Marks PA, et al. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci USA. 2004;101:18030
  12. Wetzel M, Premkumar DR, Arnold B, et al. Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis. J Neurosurg. 2005;103:549
  13. Kim MS, Blake M, Baek JH, et al. Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res. 2003;63:7291
  14. Li GC, Zhang X, Pan TJ, et al. Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. Int J Urol. 2006;13:581
  15. Woo HJ, Lee SJ, Choi BT, et al. Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells. Exp Mol Pathol. 2007;82:77
  16. Deng C, Zhang P, Harper JW, et al. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995;82:675
  17. Deep G, Singh RP, Agarwal C, et al. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene. 2006;25:1053
  18. Shimizu S, Eguchi Y, Kamiike W, et al. Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene. 1996;12:2251
  19. Kaufmann SH, Desnoyers S, Ottayiano Y, et al. Specific proteolytic cleavage of poly-(ADP-ribose) polymerase: An early maker of chemotherapy induced apoptosis. Cancer Res. 1993;53:3976
  20. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55
  21. Gerlier D, Thomasset N. Use of MTT colorimetric assay to measure cell activation. J Immunol Methods. 1986;94:57
  22. Sippel RS, Carpenter JE, Kunnimalaiyaan M, et al. Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol. 2003;285:G245
  23. Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am J Gastrointest Liver Physiol. 2005;289:G636
  24. Gartel AL, Serfas MS, Tyner AL. p21, a negative regulator of the cell cycle. Proc Soc Exp Biol Med. 1996;213:138
  25. Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-CDK protein kinase activity, is related to p21. Cell. 1994;78:67
  26. Alao JP, Stravropoulou AV, Lam EW, et al. Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Mol Cancer. 2006;5:40
  27. Chen CS, Wend SC, Tseng PH, et al. Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphate 1 complexes. J Biol Chem. 2005;280:38879
  28. Rascle A, Johnston JA, Amati B. Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5. Mol Cell Biol. 2003;23:4162
  29. Warrener R, Beamish H, Burgess A, et al. Tumor cell-selective cytotoxicity by targeting cell cycle checkpoints. FASEB J. 2003;17:1550
  30. Chen H, Carson-Walter EB, Baylin SB, et al. Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. Surgery. 1996;120:168
  31. Sippel RS, Carpenter JE, Kunnimalaiyaan M, et al. The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. Surgery. 2003;134:866

1 The authors dedicate this work to the memory of Dr. Louis Ptacek, whose fight against small cell lung cancer inspired this research.

PII: S0022-4804(06)01180-2

doi: 10.1016/j.jss.2006.12.555

Journal of Surgical Research
Volume 142, Issue 2 , Pages 219-226 , October 2007