Journal of Surgical Research
Volume 141, Issue 2 , Pages 183-191 , August 2007

Paclitaxel Interrupts TGF-β1 Signaling Between Gallbladder Epithelial Cells and Myofibroblasts

  • Ho-Soon Choi, M.D.

      Affiliations

    • H.-S.C.’s current address is Division of Gastroenterology, Hanyang University Hospital, Seoul, Korea. J.-W.C.’s current address is Department of General Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea.
    • ,
  • Christopher E. Savard, M.S.
    • ,
  • Jae-Woon Choi, M.D.
    • ,
  • Rahul Kuver, M.D.

      Affiliations

    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Box 356424, Division of Gastroenterology, University of Washington, 1959 NE Pacific St., Seattle, WA 98195.
    • ,
  • Sum P. Lee, M.D., Ph.D.

Received 17 May 2006

References 

  1. Koninger J, diMola FF, Sebastiano PD, et al. Transforming growth factor-β pathway is activated in cholecystolithiasis. Langenbecks Arch Surg. 2005;390:21
  2. Czaja MJ, Weiner FR, Flanders KC, et al. In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J Cell Biol. 1989;108:2477
  3. McCartney-Francis NL, Wahl SM. Transforming growth factor beta: A matter of life and death. J Leuk Biol. 1994;55:401
  4. Sime PJ, Xing Z, Graham FL, et al. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest. 1997;100:768
  5. Van Laethem JL, Robberecht P, Resibois A, et al. Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice. Gastroenterology. 1996;110:576
  6. Saperstein LA, Jirtle RL, Farouk M, et al. Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat. Hepatology. 1994;19:412
  7. Postlethwaite AE, Keski-Oja J, Moses HL, et al. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med. 1987;165:251
  8. Wahl SM, Hunt DA, Wakefield LM, et al. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA. 1987;84:5788
  9. Nakanuma Y, Yamaguchi K, Ohta G, et al. Pathologic features of hepatolithiasis in Japan. Hum Pathol. 1988;19:1181
  10. Jan YY, Chen MF, Wang CS, et al. Surgical treatment of hepatolithiasis: Long-term results. Surgery. 1996;120:509
  11. Matsumoto Y, Fujii H, Yoshioka M, et al. Biliary strictures as a cause of primary intrahepatic bile duct stones. World J Surg. 1986;10:867
  12. Park SM, Choi JW, Kim ST, et al. Suppression of proliferative cholangitis in a rat model by local delivery of paclitaxel. J Hepatobiliary Pancreat Surg. 2003;10:176
  13. Gelmon K. The taxoids: Paclitaxel and docetaxel. Lancet. 1994;344:1267
  14. Manthey CL, Qureshi N, Stutz PL, et al. Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages. J Exp Med. 1993;178:695
  15. Mullins DW, Martins RS, Burger CJ, et al. Tumor cell-derived TGF-β and IL-10 dysregulate paclitaxel-induced macrophage activation. J Leuk Biol. 2001;69:129
  16. Dong C, Zhiru L, Alvarez R, et al. Microtubule binding to Smads may regulate TGF-β activity. Mol Cell. 2000;5:27
  17. Kuver R, Savard C, Nguyen TD, et al. Isolation and long-term culture of gallbladder epithelial cells from wild-type and CF mice. In Vitro Cell Dev Biol Animal. 1997;33:104
  18. Nguyen TD, Koh DS, Moody MW, et al. Characterization of two distinct chloride channels in cultured dog pancreatic duct epithelial cells. Am J Physiol. 1997;272:G172
  19. Mundlos S, Chan D, Weng YM, et al. Multiexon deletions in the type I collagen COL1A2 gene in osteogenesis imperfecta type IB (Molecules containing the shortened alpha2(I) chains show differential incorporation into the bone and skin extracellular matrix). J Biol Chem. 1996;271:21068
  20. Klinkspoor JH, Yoshida T, Lee SP. Bile salts stimulate mucin secretion by cultured gallbladder epithelial cells independent of their detergent effect. Biochem J. 1998;332:257
  21. Amador E, Dorfman LE, Wacker WEC. Serum lactic dehydrogenase activity: An assessment of current assays. Clin Chem. 1963;9:391
  22. Gloushankova NA, Lyubimova AV, Tint IS, et al. Role of the microtubular system in morphological organization of normal and oncogene-transfected epithelial cells. Proc Natl Acad Sci USA. 1994;91:8597
  23. Matsuoka H, Furusawa M, Tomoda H, et al. Difference in cytotoxicity of paclitaxel against neoplastic and normal cells. Anticancer Res. 1994;14:163
  24. Schiff PB, Horwitz SB. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci USA. 1980;77:1561
  25. Savard CE, Blinman TA, Choi HS, et al. Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by gallbladder epithelial cells: Response to bacterial lipopolysaccharides. BMC Gastroenterol. 2002;2:23
  26. Reynoso-Paz S, Coppel RL, Mackay IR, et al. The immunobiology of bile and biliary epithelium. Hepatology. 1999;30:351
  27. Donaldson KL, Goolsby GL, Kiener PA, et al. Activation of p34cdc2 coincident with taxol-induced apoptosis. Cell Growth Differ. 1994;5:1041
  28. Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by Taxol. Nature. 1979;277:665
  29. Rowinsky EK, Donehower RC. Paclitaxel (Taxol). N Engl J Med. 1995;332:1004
  30. Sheppard BC, Rutten MJ, Meichsner CL, et al. Effects of paclitaxel on the growth of normal, polyposis, and cancerous human colonic epithelial cells. Cancer. 1999;85:1454
  31. Axel DI, Kunert W, Goggelmann C, et al. Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation. 1997;96:636
  32. Straubinger RM, Sharma A, Murray M, et al. Novel Taxol formulations: Taxol-containing liposomes. J Natl Cancer Inst Monogr. 1993;15:69
  33. Jordan MA, Toso RJ, Thrower D, et al. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations. Proc Natl Acad Sci USA. 1993;90:9552
  34. Sollott SJ, Cheng L, Pauly RR, et al. Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat. J Clin Invest. 1995;95:1869
  35. Lee DK, Kim HS, Kim KS, et al. The effect on porcine bile duct of a metallic stent covered with a paclitaxel-incorporated membrane. Gastrointest Endosc. 2005;61:296
  36. Park SJ, Shim WH, Ho DS, et al. A paclitaxel-eluting stent for the prevention of coronary restenosis. N Engl J Med. 2003;348:1537
  37. Sime PJ, Marr RA, Gauldie D, et al. Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol. 1998;153:825
  38. Alpini G, McGill JM, LaRusso NF. The pathobiology of biliary epithelia. Hepatology. 2002;35:1256

PII: S0022-4804(06)01183-8

doi: 10.1016/j.jss.2006.12.558

Journal of Surgical Research
Volume 141, Issue 2 , Pages 183-191 , August 2007

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