Journal of Surgical Research
Volume 142, Issue 1 , Pages 45-52 , September 2007

Protective Effects of Combined Ischemic Preconditioning and Ascorbic Acid on Mitochondrial Injury in Hepatic Ischemia/Reperfusion

  • Woo-Yong Lee, Ph.D.
    • ,
  • Jun-Seok Lee, M.S.
    • ,
  • Sun-Mee Lee, Ph.D.

      Affiliations

    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at College of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon-si, Gyeonggi-do 440-746, Korea.

Received 26 April 2006

References 

  1. Uyama O, Shiratsuki N, Matsuyama T, et al. Protective effects of superoxide dismutase on acute reperfusion injury of gerbil brain. Free Radical Biol Med. 1990;8:265
  2. Mccord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1989;312:159
  3. Clemens MG, Mcdonagh PF, Chaudry IH, et al. Hepatic microcirculatory failure after ischemia and reperfusion: Improvement with ATP-MgCl2 treatment. Am J Physiol. 1985;248:H804
  4. Rüdiger HA, Graf R, Clavien PA. Sub-lethal oxidative stress triggers the protective effects of ischemic preconditioning in the mouse liver. J Hepatol. 2003;39:972
  5. Yuan GJ, Ma JC, Gong ZJ, et al. Modulation of liver oxidant-antioxidant system by ischemic preconditioning during ischemia/reperfusion injury in rats. World J Gastroenterol. 2005;11:1825
  6. Glanemann M, Vollmar B, Nussler AK, et al. Ischemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state. J Hepatol. 2003;38:59
  7. Bilzer M, Gerbes A. Preservation injury of the liver: Mechanisms and novel therapeutic strategies. J Hepatol. 2000;32:508
  8. Lehmann TG, Wheeler MD, Schwabe RF, et al. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Hepatology. 2000;32:1255
  9. Bode AM. Metabolism of vitamin C in health and disease. Adv Pharmacol. 1997;38:21
  10. Seo MY, Lee SM. Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats. J Hepatol. 2002;36:72
  11. Johnson D, Lardy H. Isolation of liver and kidney mitochondria. Methods Enzymol. 1967;10:456
  12. Wolff SP. Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol. 1994;233:182
  13. Ellis G, Goldberg DM. Optimal conditions for the kinetic assay of serum glutamate dehydrogenase activity at 37°C. Clin Chem. 1972;18:523
  14. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem. 1969;27:502
  15. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302
  16. Elimadi A, Sapena R, Settaf A, et al. Attenuation of liver normothermic ischemia-reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative. Biochem Pharmacol. 2001;62:509
  17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248
  18. Dills RL, Klaassen CD. An isocratic reverse-phase high-performance liquid chromatographic assay for adenine nucleotides in rat liver. J Pharmacol Methods. 1985;14:189
  19. Cavalieri B, Perrelli MG, Aragno M, et al. Ischemic preconditioning attenuates the oxidant-dependent mechanisms of reperfusion cell damage and death in rat liver. Liver Transpl. 2002;8:990
  20. Zwacka RM, Zhang Y, Halldorson J, et al. CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. J Clin Invest. 1997;100:279
  21. Teoh N, Leclercq I, Pena AD, et al. Low-dose TNF-α protects against hepatic ischemia-reperfusion injury in mice: Implications for preconditioning. Hepatology. 2003;37:118
  22. Kohen R, Nyska A. Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol. 2002;30:620
  23. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA. 1989;86:6377
  24. Lee WY, Lee SM. Ischemic preconditioning protects postischemic oxidative damage to mitochondria in rat liver. Shock. 2005;28:1392
  25. Omar R, Nomikos I, Piccorelli G, et al. Prevention of postischemic lipid peroxidation and liver cell injury by iron chelation. Gut. 1989;30:510
  26. Frederiks WM, Marx F. Changes in cytoplasmic and mitochondrial enzymes in rat liver after ischemia followed by reperfusion. Exp Mol Pathol. 1987;47:291
  27. Lohse W, Otto G, Pahlig H, et al. Prognostic value of glutamyl dehydrogenase activity in clinical liver transplantation. Transplantation. 1984;38:559
  28. Fornai F, Saviozzi M, Piaggi S, et al. Localization of a glutathione-dependent dehydroascorbate reductase within the central nervous system of the rat. Neuroscience. 1999;94:937
  29. Zamzami N, Hirsch T, Dallaporta B, et al. Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomembr. 1997;29:185
  30. Leducq N, Delmas-Beauvieux MC, Bourdel-Marchasson I, et al. Mitochondrial permeability transition during hypothermic to normothermic reperfusion in rat liver demonstrated by the protective effect of cyclosporin A. Biochem J. 1998;336:501
  31. Zoratti M, Szabo I. The mitochondrial permeability transition. Biochem Biochim Biophys Acta. 1995;1241:139
  32. Kurokawa T, Kobayashi H, Nonami T, et al. Mitochondrial glutathione redox and energy producing function during liver ischemia and reperfusion. J Surg Res. 1996;66:1
  33. Palombo JD, Pomposelli JJ, Fechner KD, et al. Enhanced restoration of adenine nucleotides in rat liver following extended preservation in UW solution by provision of adenosine during reperfusion. Transplantation. 1991;51:867

PII: S0022-4804(07)00009-1

doi: 10.1016/j.jss.2006.08.043

Journal of Surgical Research
Volume 142, Issue 1 , Pages 45-52 , September 2007

Article Tools

* Image Usage & Resolution