Journal of Surgical Research
Volume 141, Issue 1 , Pages 31-39 , July 2007

Entero-Endocrine Changes After Gastric Bypass in Diabetic and Nondiabetic Patients: A Preliminary Study

  • Bryan A. Whitson, M.D.

      Affiliations

    • Department of Surgery, Division of Gastrointestinal Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Daniel B. Leslie, M.D.

      Affiliations

    • Department of Surgery, Division of Gastrointestinal Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Todd A. Kellogg, M.D.

      Affiliations

    • Department of Surgery, Division of Gastrointestinal Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Michael A. Maddaus, M.D.

      Affiliations

    • Department of Surgery, Division of Gastrointestinal Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Henry Buchwald, M.D., Ph.D.

      Affiliations

    • Department of Surgery, Division of Gastrointestinal Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Charles J. Billington, M.D.

      Affiliations

    • Department of Medicine, Section of Endocrinology and Metabolism, Center for Diabetes Research, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Sayeed Ikramuddin, M.D.

      Affiliations

    • Department of Surgery, Division of Gastrointestinal Surgery, University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at University of Minnesota Department of Surgery, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455.

Received 8 January 2007

References 

  1. Fetner R, McGinty J, Russell C, et al. Incretins, diabetes, and bariatric surgery: A review. Surg Obes Relat Dis. 2005;1:589
  2. Schauer PR, Burguera B, Ikramuddin S, et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg. 2003;238:467
  3. Schauer PR, Ikramuddin S, Gourash W, et al. Outcomes after laparoscopic Roux-en-Y gastric bypass for morbid obesity. Ann Surg. 2000;232:515
  4. Guidone C, Manco M, Valera-Mora E, et al. Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery. Diabetes. 2006;55:2025
  5. Kreymann B, Williams G, Ghatei MA, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 1987;2:1300
  6. le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2006;243:108
  7. Rubino F, Gagner M, Gentileschi P, et al. The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg. 2004;240:236
  8. Clements RH, Gonzalez QH, Long CI, et al. Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus. Am Surg. 2004;70:1
  9. Service GJ, Thompson GB, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med. 2005;353:249
  10. Cummings DE, Overduin J, Foster-Schubert KE. Gastric bypass for obesity: Mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab. 2004;89:2608
  11. Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab. 2004;287:E199
  12. Meier JJ, Gallwitz B, Kask B, et al. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes. 2004;3(suppl 53):S220
  13. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346:1623
  14. Faraj M, Havel PJ, Phelis S, et al. Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab. 2003;88:1594
  15. Lee H, Te C, Koshy S, et al. Does ghrelin really matter after bariatric surgery?. Surg Obes Relat Dis. 2006;2:538
  16. Shiiya T, Nakazato M, Mizuta M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab. 2002;87:240
  17. Mackelvie KJ, Meneilly GS, Elahi D, et al. Regulation of appetite in lean and obese adolescents following exercise: Role of acylated and desacyl ghrelin. J Clin Endocrinol Metab. 2006;(in press)
  18. Mancini MC, Costa AP, de Melo ME, et al. Effect of gastric bypass on spontaneous growth hormone and ghrelin release profiles. Obesity (Silver Spring). 2006;14:383
  19. Couce ME, Cottam D, Esplen J, et al. Is ghrelin the culprit for weight loss after gastric bypass surgery? (A negative answer). Obes Surg. 2006;16:870
  20. Busetto L, Segato G, De Luca MF, et al. High ghrelin concentration is not a predictor of less weight loss in morbidly obese women treated with laparoscopic adjustable gastric banding. Obes Surg. 2006;16:1068
  21. Dixon AF, Dixon JB, O’Brien PE. Laparoscopic adjustable gastric banding induces prolonged satiety: A randomized blind crossover study. J Clin Endocrinol Metab. 2005;90:813

PII: S0022-4804(07)00090-X

doi: 10.1016/j.jss.2007.02.022

Journal of Surgical Research
Volume 141, Issue 1 , Pages 31-39 , July 2007

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