Journal of Surgical Research
Volume 146, Issue 1 , Pages 73-80 , 1 May 2008

Increased Rate of Hair Regrowth in Mice with Constitutive Overexpression of Del1

  • Gloria P. Hsu, M.D.

      Affiliations

    • Department of Surgery, Stanford University School of Medicine, Stanford, California
  • ,
  • Jonathan A. Mathy, M.D.

      Affiliations

    • Department of Surgery, Stanford University School of Medicine, Stanford, California
  • ,
  • Zhen Wang, M.D.

      Affiliations

    • Department of Surgery, Stanford University School of Medicine, Stanford, California
  • ,
  • Wei Xia, M.D.

      Affiliations

    • Fourth Military Medical School, Xi’an, China
  • ,
  • Gordon Sakamoto, M.D.

      Affiliations

    • Department of Medicine, Stanford University School of Medicine, Stanford, California
  • ,
  • Ramendra Kundu, Ph.D.

      Affiliations

    • Department of Medicine, Stanford University School of Medicine, Stanford, California
  • ,
  • Michael T. Longaker, M.D., M.B.A.

      Affiliations

    • Department of Surgery, Stanford University School of Medicine, Stanford, California
  • ,
  • Thomas Quertermous, M.D.

      Affiliations

    • Department of Medicine, Stanford University School of Medicine, Stanford, California
  • ,
  • George P. Yang, M.D., Ph.D.

      Affiliations

    • Department of Surgery, Stanford University School of Medicine, Stanford, California
    • Palo Alto VA Health Care System, Palo Alto, California
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, M/C 5148, Stanford, CA 94305.

Received 23 January 2007

References 

  1. Chatelard P, Guibourt C. Long-term results with a Palmaz stent in the femoropopliteal arteries. J Cardiovasc Surg (Torino). 1996;37:67
  2. Henry M, Amor M, Ethevenot G, et al. Palmaz stent placement in iliac and femoropopliteal arteries: Primary and secondary patency in 310 patients with 2- to 4-year follow-up. Radiology. 1995;197:167
  3. Srinivas VS, Brooks MM, Detre KM, et al. Contemporary percutaneous coronary intervention versus balloon angioplasty for multivessel coronary artery disease: A comparison of the National Heart, Lung, and Blood Institute Dynamic Registry and the Bypass Angioplasty Revascularization Investigation (BARI) study. Circulation. 2002;106:1627
  4. Williams DO, Holubkov R, Yeh W, et al. Percutaneous coronary intervention in the current era compared with 1985–1986: The National Heart, Lung, and Blood Institute Registries. Circulation. 2000;102:2945
  5. Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone marrow derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med. 2001;7:1194
  6. Toft DJ, Rosenberg SB, Bergers G, et al. Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression. Proc Natl Acad Sci USA. 2001;98:13055
  7. Rees RS, Robson MC, Smiell JM, et al. Becaplermin gel in the treatment of pressure ulcers: A phase II randomized, double-blind, placebo-controlled study. Wound Repair Regen. 1999;7:141
  8. Lange-Asschenfeldt B, Velasco P, Streit M, et al. The angiogenesis inhibitor vasostatin does not impair wound healing at tumor-inhibiting doses. J Invest Dermatol. 2001;117:1036
  9. Miller MS. Use of topical recombinant human platelet-derived growth factor-BB (becaplermin) in healing of chronic mixed arteriovenous lower extremity diabetic ulcers. J Foot Ankle Surg. 1999;38:227
  10. Mundhenke C, Thomas JP, Wilding G, et al. Tissue examination to monitor antiangiogenic therapy: A phase I clinical trial with endostatin. Clin Cancer Res. 2001;7:3366
  11. Hidai C, Zupancic T, Penta K, et al. Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the αvβ3 integrin receptor. Genes Dev. 1998;12:21
  12. Penta K, Varner JA, Liaw L, et al. Del1 induces integrin signaling and angiogenesis by ligation of αvβ3. J Biol Chem. 1999;274:11101
  13. Rezaee M, Penta K, Quertermous T. Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin αvβ3. Am J Physiol Heart Circ Physiol. 2002;282:H1924
  14. Zhong J, Eliceiri B, Stupack D, et al. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003;112:30
  15. Aoka Y, Johnson FL, Penta K, et al. The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. Microvasc Res. 2002;64:148
  16. Fuchs E. Beauty is skin deep: The fascinating biology of the epidermis and its appendages. Harvey Lect. 1998;94:47
  17. Fuchs E, Merrill BJ, Jamora C, et al. At the roots of a never-ending cycle. Dev Cell. 2001;1:13
  18. Fuchs E, Raghavan S. Getting under the skin of epidermal morphogenesis. Nat Rev Genet. 2002;3:199
  19. Hardy MH. The secret life of the hair follicle. Trends Genet. 1992;8:55
  20. Muller-Rover S, Handjiski B, van der Veen C, et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001;117:3
  21. Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev. 2001;81:449
  22. Millar SE. Molecular mechanisms regulating hair follicle development. J Invest Dermatol. 2002;118:216
  23. Chiang C, Swan RZ, Grachtchouk M, et al. Essential role for sonic hedgehog during hair follicle morphogenesis. Dev Biol. 1999;205:1
  24. Callahan CA, Oro AE. Monstrous attempts at adnexogenesis: Regulating hair follicle progenitors through sonic hedgehog signaling. Curr Opin Genet Dev. 2001;11:541
  25. Oro AE, Higgins KM, Hu Z, et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science. 1997;276:817
  26. Morris RJ, Liu Y, Marles L, et al. Capturing and profiling adult hair follicle stem cells. Nat Biotechnol. 2004;22:411
  27. Oshima H, Rochat A, Kedzia C, et al. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell. 2001;104:233
  28. Taylor G, Lehrer MS, Jensen PJ, et al. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell. 2000;102:451
  29. Raghavan S, Bauer C, Mundschau G, et al. Conditional ablation of beta1 integrin in skin (Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination). J Cell Biol. 2000;150:1149
  30. Zhu AJ, Haase I, Watt FM. Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc Natl Acad Sci USA. 1999;96:6728
  31. Li J, Tzu J, Chen Y, et al. Laminin-10 is crucial for hair morphogenesis. EMBO J. 2003;22:2400
  32. Hanayama R, Tanaka M, Miwa K, et al. Identification of a factor that links apoptotic cells to phagocytes. Nature. 2002;417:182
  33. Hanayama R, Tanaka M, Miyasaka K, et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science. 2004;304:1147
  34. Hanayama R, Tanaka M, Miwa K, et al. Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells. J Immunol. 2004;172:3876
  35. Mecklenburg L, Tobin DJ, Muller-Rover S, et al. Active hair growth (anagen) is associated with angiogenesis. J Invest Dermatol. 2000;114:909
  36. Yano K, Brown LF, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest. 2001;107:409

1 Gloria P. Hsu and Jonathan A. Mathy contributed equally to this work.

PII: S0022-4804(07)00092-3

doi: 10.1016/j.jss.2007.02.024

Journal of Surgical Research
Volume 146, Issue 1 , Pages 73-80 , 1 May 2008