Journal of Surgical Research
Volume 142, Issue 2 , Pages 239-245 , October 2007

A Vitamin D Analogue Inhibits Colonic Carcinogenesis in the AOM/DSS Model

  • Alessandro Fichera, M.D.

      Affiliations

    • Department of Surgery, University of Chicago, Chicago, Illinois
    • Corresponding Author InformationTo whom correspondence should be addressed at Department of Surgery, MC 5031, University of Chicago Hospitals, 5841 S. Maryland Avenue, Chicago, IL 60637.
    • ,
  • Nathaniel Little, B.A.

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Urszula Dougherty, B.A.

      Affiliations

    • Department of Surgery, University of Chicago, Chicago, Illinois
    • ,
  • Reba Mustafi, Ph.D.

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Sonia Cerda, Ph.D.

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Yan Chun Li, Ph.D.

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Jorge Delgado, M.D.

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Amrita Arora

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, Illinois
    • ,
  • Lucas K. Campbell, M.D.

      Affiliations

    • Department of Pathology, University of Chicago, Chicago, Illinois
    • ,
  • Loren Joseph, M.D.

      Affiliations

    • Department of Pathology, University of Chicago, Chicago, Illinois
    • ,
  • John Hart, M.D.

      Affiliations

    • Department of Pathology, University of Chicago, Chicago, Illinois
    • ,
  • Amy Noffsinger, M.D.

      Affiliations

    • Department of Pathology, University of Chicago, Chicago, Illinois
    • ,
  • Marc Bissonnette, M.D.

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, Illinois

Received 1 January 2007

References 

  1. Itzkowitz SH. Colorectal cancer in inflammatory bowel disease. In:  Schmiegel W,  Scholmerich J editor. Colorectal cancer: Molecular mechanisms, premalignant state and its prevention. Titisee, Germany: Kluwer Academic Publishers; 1998;p. 118–126
  2. Itzkowitz SH, Yio X. Inflammation and cancer IV (Colorectal cancer in inflammatory bowel disease: The role of inflammation). Am J Physiol Gastrointest Liver Physiol. 2004;287:G7
  3. Ziv Y, Fazio VW, Strong SA, et al. Ulcerative colitis and coexisting colorectal cancer: Recurrence rate after restorative proctocolectomy. Ann Surg Oncol. 1994;1:512
  4. Meltzer SJ. Molecular genetics of ulcerative colitis-associated neoplasia. In:  Schmiegel W,  Scholmerich J editor. Colorectal cancer: Molecular mechanisms, premalignant state and its prevention. Titisee, Germany: Kluwer Academic Publishers; 1998;p. 107–117
  5. Agoff SN, Brentnall TA, Crispin DA, et al. The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. Am J Pathol. 2000;157:737
  6. Elson CO, Sartor RB, Tennyson GS, et al. Experimental models of inflammatory bowel disease. Gastroenterology. 1995;109:1344
  7. Cooper HS, Murthy SN, Shah RS, et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69:238
  8. Tessner TG, Cohn SM, Schloemann S, et al. Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice. Gastroenterology. 1998;115:874
  9. Wali RK, Bissonnette M, Khare S, et al. 1-alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis. Cancer Res. 1995;55:3050
  10. Fichera A, Little N, Jagadeeswaran S, et al. EGFR signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res. 2007;67:827
  11. Tanaka T, Kohno H, Suzuki R, et al. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 2003;94:965
  12. Bolt MJ, Cerda S, Mustafi R, et al. Vitamin D inhibits Caco-2 cell growth: Role of vitamin D receptor and p21wafl. Gastroenterology. 2003;124:A
  13. Marchiani S, Bonaccorsi L, Ferruzzi P, et al. The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells. J Cancer Res Clin Oncol. 2006;132:408
  14. Thomas MG, Tebbutt S, Williamson RC. Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line. Gut. 1992;33:1660
  15. Thomas MG, Nugent KP, Forbes A, et al. Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis. Gut. 1994;35:1718
  16. Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26:662
  17. Zhang X, Nicosia SV, Bai W. Vitamin D receptor is a novel drug target for ovarian cancer treatment. Curr Cancer Drug Targets. 2006;6:229
  18. Han SA, Chun H, Park CM, et al. Prognostic significance of beta-catenin in colorectal cancer with liver metastasis. Clin Oncol (R Coll Radiol). 2006;18:761
  19. Segditsas S, Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene. 2006;25:7531
  20. Grady WM, Myeroff LL, Swinler SE, et al. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res. 1999;59:320
  21. Palmer HG, Gonzalez-Sancho JM, Espada J, et al. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol. 2001;154:369
  22. Yanagisawa J, Yanagi Y, Masuhiro Y, et al. Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. Science. 1999;283:1317
  23. Sun J, Hobert ME, Duan Y, et al. Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. Am J Physiol Gastrointest. Liver Physiol. 2005;289:G129
  24. Sun J, Kong J, Duan Y, et al. Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor. Am J Physiol Endocrinol Metab. 2006;291:E315
  25. Park CM, Reid PE, Walker DC, et al. A simple, practical ‘swiss roll’ method of preparing tissues for paraffin or methacrylate embedding. J Microsc. 1987;145:115
  26. Marsh KA, Stamp GW, Kirkland SC. Isolation and characterization of multiple cell types from a single human colonic carcinoma: Tumourigenicity of these cell types in a xenograft system. J Pathol. 1993;170:441
  27. Cerda SR, Mustafi R, Little H, et al. Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. Oncogene. 2006;25:3123
  28. Sebolt-Leopold JS, Dudley DT, Herrera R, et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med. 1999;5:810
  29. Pelengaris S, Khan M, Evan G. c-MYC: More than just a matter of life and death. Nat Rev Cancer. 2002;2:764
  30. Bissonnette M, Khare S, von Lintig FC, et al. Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: Effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. Cancer Res. 2000;60:4602
  31. Liou HC, Baltimore D. Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr Opin Cell Biol. 1993;5:477
  32. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145
  33. Soloff MS, Cook DL, Jeng YJ, et al. In situ analysis of interleukin-1-induced transcription of cox-2 and il-8 in cultured human myometrial cells. Endocrinology. 2004;145:1248
  34. Froicu M, Weaver V, Wynn TA, et al. A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol. 2003;17:2386
  35. Cantorna MT, Munsick C, Bemiss C, et al. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr. 2000;130:2648
  36. Greenstein AJ. Cancer in inflammatory bowel disease. Mt Sinai J Med. 2000;67:227
  37. Baldassarre G, Nicoloso MS, Schiappacassi M, et al. Linking inflammation to cell cycle progression. Curr Pharm Des. 2004;10:1653
  38. Gurlek A, Pittelkow MR, Kumar R. Modulation of growth factor/cytokine synthesis and signaling by 1alpha, 25-dihydroxyvitamin D(3): Implications in cell growth and differentiation. Endocr Rev. 2002;23:763
  39. Sjoqvist U. Dysplasia in ulcerative colitis—clinical consequences?. Langenbecks Arch Surg. 2004;389:354

PII: S0022-4804(07)00118-7

doi: 10.1016/j.jss.2007.02.038

Journal of Surgical Research
Volume 142, Issue 2 , Pages 239-245 , October 2007

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