Journal of Surgical Research
Volume 141, Issue 1 , Pages 45-52 , July 2007

Effective Ablation of Pancreatic Cancer Cells in SCID Mice Using Systemic Adenoviral RIP-TK/GCV Gene Therapy

Received 8 January 2007

References 

  1. Jemal A, Tiwari RC, Murray T, et al. Cancer Statistics, 2004. CA Cancer J Clin. 2004;54:8
  2. Lowenfels AB, Maisonneuve P. Epidemiology and prevention of pancreatic cancer. Jpn J Clin Oncol. 2004;34:238
  3. Blaszkowsky L. Treatment of advanced and metastatic pancreatic cancer. Front Biosci. 1998;3:E214
  4. Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene. 2006;25:4798
  5. Tamada K, Wang XP, Brunicardi FC. Molecular targeting of pancreatic disorders. World J Surg. 2005;29:325
  6. Wang XP, Yazawa K, Templeton NS, et al. Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice. World J Surg. 2005;29:339
  7. Wang J, Lu XX, Chen DZ, et al. Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer. World J Gastroenterol. 2004;10:400
  8. Wang XP, Yazawa K, Yang J, et al. Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter. J Gastrointest Surg. 2004;8:98;Discussion 106
  9. Makinen K, Loimas S, Wahlfors J, et al. Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer. J Gene Med. 2000;2:361
  10. Carrio M, Romagosa A, Mercade E, et al. Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene. Gene Ther. 1999;6:547
  11. Hajri A, Wack S, Lehn P, et al. Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes. Cancer Gene Ther. 2004;11:16
  12. Poulsen TT, Pedersen N, Poulsen HS. Replacement and suicide gene therapy for targeted treatment of lung cancer. Clin Lung Cancer. 2005;6:227
  13. Tong XW, Kieback DG, Ramesh R, et al. Molecular aspects of ovarian cancer (Is gene therapy the solution?). Hematol Oncol Clin North Am. 1999;13:109
  14. Li Z, Ding Q, Li Y, et al. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 2006;236:58
  15. Deharvengt S, Wack S, Aprahamian M, et al. Transcriptional tumor-selective promoter targeting of E. coli purine nucleoside phosphorylase for pancreatic cancer suicide gene therapy. J Gene Med. 2005;7:672
  16. Yang L, Cao Z, Li F, et al. Tumor-specific gene expression using the survivin promoter is further increased by hypoxia. Gene Ther. 2004;11:1215
  17. Tirone TA, Fagan SP, Templeton NS, et al. Insulinoma-induced hypoglycemic death in mice is prevented with β cell-specific gene therapy. Ann Surg. 2001;233:603
  18. Tirone TA, Wang XP, Templeton NS, et al. Cell-specific cytotoxicity of human pancreatic adenocarcinoma cells using rat insulin promoter thymidine kinase-directed gene therapy. World J Surg. 2004;28:826
  19. Wesseling JG, Yamamoto M, Adachi Y, et al. Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. Cancer Gene Ther. 2001;8:990
  20. Harris JD, Gutierrez AA, Hurst HC, et al. Gene therapy for cancer using tumor-specific pro-drug activation. Gene Ther. 1994;1:170
  21. Facfarlane WM, Shepherd RM, Cosgrove KE, et al. Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+. Diabetes. 2000;49:418
  22. Glick E, Leshkowitz D, Walker MD. Transcription factor β2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter. J Biol. Chem. 2000;275:2199
  23. Ohneda K, Mirmira RG, Wang J, et al. The homeo domain of PDX-1 mediates multiple protein–protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol Cell Biol. 2000;20:900
  24. Dumonteil E, Laser B, Constant I, et al. Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and β-2. J Biol Chem. 1998;273:19945
  25. Gerrish K, Gannon M, Shih D, et al. Pancreatic β cell-specific transcription of the pdx-1 gene. J Biol Chem. 2000;275:3485
  26. Koizumi M, Doi R, Toyoda E, et al. Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer. Surgery. 2003;134:260
  27. Liu S, Wang XP, Brunicardi FC. Enhanced cytotoxicity of RIPTK gene therapy of pancreatic cancer via PDX-1 codelivery. J Surg Res. 2007;137:1
  28. Davis AR, Meyers K, Wilson JM. High throughput method for creating and screening recombinant adenoviruses. Gene Ther. 1998;5:1148
  29. Song JS, Kim HP, Yoon WS, et al. Adenovirus-mediated suicide gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter induced apoptosis of ovarian cancer cell line. Biosci Biotechnol Biochem. 2003;67:2344
  30. Chen JF, Huang ZH, Huang YY, et al. Construction of recombinant adenoviruses encoding TK suicide gene driven by VEGF promoter using efficient AdEasier-1 system. Ai Zheng. 2004;23:1093
  31. Wang J, Yao M, Zhang Z, et al. Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation. FEBS Lett. 2003;546:315
  32. Yoshimura I, Ikegami S, Suzuki S, et al. Adenovirus mediated prostate specific enzyme prodrug gene therapy using prostate specific antigen promoter enhanced by the Cre-loxP system. J Urol. 2002;168:2659
  33. Vorburger SA, Hunt KK. Adenoviral gene therapy. Oncologist. 2002;7:46
  34. Ghosh SS, Gopinath P, Ramesh A. Adenoviral vectors: A promising tool for gene therapy. Appl Biochem Biotechnol. 2006;133:9
  35. Relph KL, Harrington KJ, Pandha H. Adenoviral strategies for the gene therapy of cancer. Semin Oncol. 2005;32:573
  36. Aoki K, Yoshida T, Matsumoto N, et al. Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Hum Gene Ther. 1997;8:1105
  37. Ramirez PJ, Vickers SM. Adenoviral gene therapy for pancreatic adenocarcinoma. Curr Surg. 2004;61:351
  38. Seymour NE, Brunicardi FC, Chaiken RL, et al. Reversal of abnormal glucose production after pancreatic resection by pancreatic polypeptide administration in man. Surgery. 1988;104:119
  39. Lundqvist A, Noffz G, Pavlenko M, et al. Nonviral and viral gene transfer into different subsets of human dendritic cells yield comparable efficiency of transfection. J Immunother. 2002;25:445
  40. Miyatsuka T, Kaneto H, Shiraiwa T, et al. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. 2006;20:1435

PII: S0022-4804(07)00121-7

doi: 10.1016/j.jss.2007.02.041

Journal of Surgical Research
Volume 141, Issue 1 , Pages 45-52 , July 2007