Journal of Surgical Research
Volume 142, Issue 2 , Pages 263-267 , October 2007

Beating and Arrested Intramyocardial Injections Are Associated with Significant Mechanical Loss: Implications for Cardiac Cell Transplantation

  • Wes Hudson, M.D.

      Affiliations

    • Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina
    • Wes Hudson and Dorian deFreitas contributed equally to this work.
    • ,
  • Maria C. Collins, B.S.

      Affiliations

    • Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina
    • ,
  • Dorian deFreitas, M.D.

      Affiliations

    • Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina
    • Wes Hudson and Dorian deFreitas contributed equally to this work.
    • ,
  • You S. Sun, M.D.

      Affiliations

    • Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina
    • ,
  • Barbara Muller-Borer, Ph.D.

      Affiliations

    • Division of Cardiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina
    • ,
  • Alan P. Kypson, M.D.

      Affiliations

    • Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, LSB-Room 177, Greenville, NC 27834.

Received 8 January 2007

References 

  1. Pagani FD, DerSimonian H, Zawadzka A, et al. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans (Histological analysis of cell survival and differentiation). J Am Coll Cardiol. 2003;41:879
  2. Teng CJ, Luo J, Chiu RCJ, et al. Massive mechanical loss of microspheres with direct intramyocardial injection in the beating heart: Implications for cellular cardiomyoplasty. J Thorac Cardiovasc Surg. 2006;132:628
  3. Grossman PM, Han Z, Palasis M, et al. Incomplete retention after direct myocardial injection. Cathet Cardiovasc Intervent. 2002;55:392
  4. Perin EC, Lopez J. Methods of stem cell delivery in cardiac diseases. Nat Clin Prac. 2006;3(Supp 1):S110
  5. Hou D, Youssef EA, Brinton TJ, et al. Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation. 2005;112(Supp I):I
  6. Dow J, Simkhovich BZ, Kedes L, et al. Washout of transplanted cells from the heart: A potential new hurdle for cell transplantation therapy. Cardiovasc Res. 2005;67:301
  7. Freyman T, Polin G, Osman H, et al. A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J. 2006;27:1114
  8. Rezaee M, Yeung AC, Altman P, et al. Evaluation of the percutaneous intramyocardial injection for local myocardial treatment. Cathet Cardiovasc Intervent. 2001;53:271
  9. Muller-Borer B, Gunst PR, Collins MC, et al. Long-term labeling of mesenchymal stem cells using quantum dot bioconjugates. Circulation. 2006;114(Supp II):II
  10. Bridges CR, Gopal K, Holt DE, et al. Efficient myocyte gene delivery with complete cardiac surgical isolation in situ. J Thorac Cardiovasc Surg. 2005;130:1364

PII: S0022-4804(07)00170-9

doi: 10.1016/j.jss.2007.03.021

Journal of Surgical Research
Volume 142, Issue 2 , Pages 263-267 , October 2007

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