Journal of Surgical Research
Volume 144, Issue 1 , Pages 8-16 , January 2008

PDX-1 Expression Is Associated with Islet Proliferation In Vitro and In Vivo

Received 22 June 2006

References 

  1. Debas HT. Molecular insights into the development of the pancreas. Am J Surg. 1997;174:227
  2. Sander M, German MS. The beta cell transcription factors and development of the pancreas. J Mol Med. 1997;75:327
  3. Silver K, Yao F. ARIP cells as a model for pancreatic beta cell growth and development. Pancreas. 2001;22:141
  4. Slack JM. Developmental biology of the pancreas. Development. 1995;121:1569
  5. Ashizawa S, Brunicardi FC, Wang XP. PDX-1 and the pancreas. Pancreas. 2004;28:109
  6. Jamal AM, Lipsett M, Sladek R, et al. Morphogenetic plasticity of adult human pancreatic islets of Langerhans. Cell Death Differ. 2005;12:702
  7. Sharma A, Zangen DH, Reitz P, et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999;48:507
  8. Bretherton-Watt D, Gore N, Boam DS. Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter. Biochem J. 1996;313:495
  9. Carty MD, Lillquist JS, Peshavaria M, et al. Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells. J Biol Chem. 1997;272:11986
  10. Serup P, Jensen J, Andersen FG, et al. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc Natl Acad Sci USA. 1996;93:9015
  11. Watada H, Kajimoto Y, Miyagawa J, et al. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes. 1996;45:1826
  12. Bonner-Weir S. Islet growth and development in the adult. J Mol Endocrinol. 2000;24:297
  13. Johnson JD, Ahmed NT, Luciani DS, et al. Increased islet apoptosis in Pdx1+/[minus] mice. J Clin Invest. 2003;111:1147
  14. Kitamura T, Nakae J, Kitamura Y, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002;110:1839
  15. Kritzik MR, Krahl T, Good A, et al. Transcription factor expression during pancreatic islet regeneration. Mol Cell Endocrinol. 2000;164:99
  16. Kulkarni RN, Jhala US, Winnay JN, et al. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004;114:828
  17. Taylor-Fishwick DA, Shi W, Pittenger GL, et al. PDX-1 can repress stimulus-induced activation of the INGAP promoter. J Endocrinol. 2006;188:611
  18. Tuttle RL, Gill NS, Pugh W, et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med. 2001;7:1133
  19. Kumar U, Sasi R, Suresh S, et al. Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. Diabetes. 1999;48:77
  20. Portela-Gomes GM, Stridsberg M, Grimelius L, et al. Expression of the five different somatostatin receptor subtypes in endocrine cells of the pancreas. Appl Immunohistochem Mol Morphol. 2000;8:126
  21. Miller CP, McGehee RE, Habener JF. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 1994;13:1145
  22. Buscail L, Delesque N, Esteve JP, et al. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: Mediation by human somatostatin receptor subtypes SSTR1 and SSTR2. Proc Natl Acad Sci USA. 1994;91:2315
  23. Cordelier P, Esteve JP, Bousquet C, et al. Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5. Proc Natl Acad Sci USA. 1997;94:9343
  24. Lahlou H, Guillermet J, Hortala M, et al. Molecular signaling of somatostatin receptors. Ann NY Acad Sci. 2004;1014:121
  25. Lamberts SW, de Herder WW, Hofland LJ. Somatostatin analogs in the diagnosis and treatment of cancer. Trends Endocrinol Metab. 2002;13:451
  26. Schally AV. Oncological applications of somatostatin analogues. Cancer Res. 1988;48:6977
  27. Sharma K, Patel YC, Srikant CB. Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3. Mol Endocrinol. 1996;10:1688
  28. Wang XP, Norman MA, Yang J, et al. Double-gene ablation of SSTR1 and SSTR5 results in hyperinsulinemia and improved glucose tolerance in mice. Surgery. 2004;136:585
  29. Wang XP, Norman M, Yang J, et al. The effect of global SSTR5 gene ablation on the endocrine pancreas and glucose regulation in aging mice. J Surg Res. 2005;129:64
  30. Wang XP, Yang J, Norman MA, et al. SSTR5 ablation in islet results in alterations in glucose homeostasis in mice. FEBS Lett. 2005;579:3107
  31. Wang XP, Norman M, Yang J, et al. Alterations in glucose homeostasis in SSTR1 gene-ablated mice. Mol Cell Endocrinol. 2006;247:82
  32. Baeyens L, De BS, Lardon J, et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia. 2005;48:49
  33. Zhou J, Pineyro MA, Wang X, et al. Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors. J Cell Physiol. 2002;192:304
  34. Wang XP, Li ZJ, Magnusson J, et al. Tissue MicroArray analyses of pancreatic duodenal homeobox-1 in human cancers. World J Surg. 2005;29:334
  35. Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest. 1983;71:1544
  36. Abraham EJ, Leech CA, Lin JC, et al. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology. 2002;143:3152
  37. Koizumi M, Doi R, Toyoda E, et al. Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer. Surgery. 2003;134:260
  38. Tirone TA, Wang XP, Templeton NS, et al. Cell-specific cytotoxicity of human pancreatic adenocarcinoma cells using rat insulin promoter thymidine kinase-directed gene therapy. World J Surg. 2004;28:826
  39. Bulotta A, Hui H, Anastasi E, et al. Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. J Mol Endocrinol. 2002;29:347
  40. Kayali AG, Stotland A, Gunst KV, et al. Growth factor-induced signaling of the pancreatic epithelium. J Endocrinol. 2005;185:45
  41. Qiu Y, Guo M, Huang S, et al. Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol. 2002;22:412
  42. Stoffers DA, Kieffer TJ, Hussain MA, et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 2000;49:741
  43. Wang X, Zhou J, Doyle ME, et al. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology. 2001;142:1820
  44. Docherty HM, Hay CW, Ferguson LA, et al. Relative contribution of PDX-1, MafA and E47/beta2 to the regulation of the human insulin promoter. Biochem J. 2005;389:813
  45. Koizumi M, Doi R, Toyoda E, et al. Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver. Surgery. 2004;136:449
  46. Samson SL, Chan L. Gene therapy for diabetes: Reinventing the islet. Trends Endocrinol Metab. 2006;17:92
  47. Tang DQ, Cao LZ, Burkhardt BR, et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes. 2004;53:1721
  48. Holland AM, Gonez LJ, Naselli G, et al. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes. 2005;54:2586

PII: S0022-4804(07)00275-2

doi: 10.1016/j.jss.2007.04.018

Journal of Surgical Research
Volume 144, Issue 1 , Pages 8-16 , January 2008