Journal of Surgical Research
Volume 144, Issue 1 , Pages 36-42 , January 2008

Ergothioneine Modulates Proinflammatory Cytokines and Heat Shock Protein 70 in Mesenteric Ischemia and Reperfusion Injury

  • Omer Sakrak, M.D.

      Affiliations

    • Department of General Surgery, Gazi University, School of Medicine, Ankara, Turkey
    • ,
  • Mustafa Kerem, M.D.

      Affiliations

    • Department of General Surgery, Gazi University, School of Medicine, Ankara, Turkey
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of General Surgery, Faculty of Medicine, Gazi University, 06510 Besevler, Ankara, Turkey.
    • ,
  • Abdulkadir Bedirli, M.D.

      Affiliations

    • Department of General Surgery, Gazi University, School of Medicine, Ankara, Turkey
    • ,
  • Hatice Pasaoglu, M.D.

      Affiliations

    • Department of Biochemistry, Gazi University, School of Medicine, Ankara, Turkey
    • ,
  • Nalan Akyurek, M.D.

      Affiliations

    • Department of Pathology, Gazi University, School of Medicine, Ankara, Turkey
    • ,
  • Ebru Ofluoglu, Ph.D.

      Affiliations

    • Department of Biochemistry, Gazi University, School of Medicine, Ankara, Turkey
    • ,
  • Fatma Ayça Gültekin, M.D.

      Affiliations

    • Department of General Surgery, Gazi University, School of Medicine, Ankara, Turkey

Received 5 October 2006

References 

  1. Brandt LJ, Boley SJ. Intestinal ischemia. In:  Feldman M,  Friedman IS,  Sleisenger MH editor. Sleinsenger and Fordtran’s gastrointestinal and liver disease. Philadelphia, PA: Saunders; 2002;p. 2321–2340
  2. Collard CD, Gelman S. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology. 2001;94:1133
  3. Saugstad OD. Hypoxanthine as an indicator of hypoxia: Its role in health and disease through free radical production. Pediatr Res. 1988;23:143
  4. Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol. 2000;190:255
  5. Tsuruma T, Yagihashi A, Matsuno T, et al. The heat-shock protein 70 family reduces ischemia/reperfusion injury in small intestine. Transplant Proc. 1996;28:2629
  6. Jaattela M. Heat shock proteins as cellular lifeguards. Ann Med. 1999;31:261
  7. Fleming SD, Starnes BW, Kiang JG, et al. Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats. J Appl Physiol. 2002;92:2600
  8. Aruoma OI, Spencer JP, Mahmood N. Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food Chem Toxicol. 1999;37:1043
  9. Stojadinovic A, Kiang J, Smallridge R, et al. Induction of heat-shock protein 72 protects against ischemia/reperfusion in rat small intestine. Gastroenterology. 1995;109:505
  10. Hotchkiss R, Nunnally I, Lindquist S, et al. Hyperthermia protects mice against the lethal effects of endotoxin. Am J Physiol. 1993;265:R1447
  11. Motohashi N, Mori I. Thiol-induced hydroxyl radical formation and scavenger effect of thiocarbamides on hydroxyl radicals. J Inorg Biochem. 1986;26:205
  12. Bedirli A, Sakrak O, Muhtaroglu S, et al. Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70. J Surg Res. 2004;122:96
  13. Megison SM, Horton JW, Chao H, Walker PB. A new model for intestinal ischemia in the rat. J Surg Res. 1990;49:168
  14. Ohkawa H, Ohishi N, Yagı K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351
  15. Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity (Assessment of inflammation in rat and hamster models). Gastroenterology. 1984;87:1344
  16. Chiu CJ, McArdle AH, Brown R, et al. Intestinal mucosal lesion in low-flow states (I. A morphological, hemodynamic, and metabolic reappraisal). Arch Surg. 1970;101:478
  17. Beckmann RP, Mizzen LE, Welch WJ. Interaction of HSP 70 with newly synthesized proteins: Implications for protein folding and assembly. Science. 1990;248:850
  18. Kawano H, Otani M, Takeyama K, et al. Studies on ergothioneine (VI. Distribution and fluctuations of ergothioneine in rats). Chem Pharm Bull. 1982;30:1760
  19. Kaneko L, Takeuchi Y, Yamaka Y, et al. Quantitative determination of ergothionine in plasma and tissue by TLC-dosimetry. Chem Pharm Bull. 1980;28:3093
  20. Mitsuyama H, May JM. Uptake and anti-oxidant effects of ergothionine in human erytrocytes. Clin Sci. 1999;97:407
  21. Moon R, Parikh AA, Szabo C, et al. Complement C3 production in human intestinal epithelial cells is regulated by interleukin-1β and tumor necrosis factor-α. Arch Surg. 1997;32:1289
  22. Zingarelli B, Sheehan M, Wong HR. Nuclear factor-kappa B as a therapeutic target in critical care medicine. Crit Care Med. 2003;31:S105
  23. Parikh AA, Moon MR, Pritts TA, et al. IL-1β induction of NFKB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock. 2000;13:8
  24. Blackwell TS, Christmas JW. The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol. 1997;17:3
  25. Rahman I. Oxidative stress transcription factors and chromatin remodeling in lung inflammation. Biochem Pharmacol. 2000;60:1041
  26. Rahman I, Antonicelli F, MacNee W. Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells. J Biol Chem. 1999;274:5088
  27. Rahman I, Gilmour PS, Jimenez LA, et al. Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells. Biochem Biophys Res Commun. 2003;302:860
  28. Abravaya K, Myers MP, Murphy SP, et al. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev. 1992;6:1153
  29. Hirakawa T, Rokutan K, Nikawa T, et al. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology. 1996;111:345
  30. Schoeniger LO, Andreoni KA, Ott GR, et al. Induction of heat-shock gene expression in postischemic pig liver depends on superoxide generation. Gastroenterology. 1994;106:177
  31. Gasbarrini A, Esposti SD, Di Campli C, et al. Effect of ischemia–reperfusion on heat shock protein 70 and 90 gene expression in rat liver: Relation to nutritional status. Dig Dis Sci. 1998;43:2601

PII: S0022-4804(07)00277-6

doi: 10.1016/j.jss.2007.04.020

Journal of Surgical Research
Volume 144, Issue 1 , Pages 36-42 , January 2008

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