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Journal of Surgical Research
Volume 147, Issue 1
, Pages 23-33
, 1 June 2008
Interleukin-6 Mediates G0/G1 Growth Arrest in Hepatocellular Carcinoma Through a STAT 3-Dependent Pathway
References
- . Pathogenesis of hepatocellular carcinoma. Clin Liver Dis. 2001;5:69
- Molecular pathogenesis of hepatocellular carcinoma. J Surg Res. 2006;136:125
- . Hepatocellular carcinoma—history, current status and perspectives. Dig Liver Dis. 2002;34:613
- Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005;9:191;v
- . Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology. 2002;122:1609
- Liver regeneration. J Am Coll Surg. 2003;197:634
- . Cytokines and the hepatic acute-phase response. Semin Liver Dis. 1999;19:141
- Interleukin 6 and liver regeneration. Gut. 2000;47:309
- Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA. 1997;94:1441
- Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003;374:1
- Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity. 1996;5:449
- . Mammalian MAP kinase signalling cascades. Nature. 2001;410:37
- Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. Liver Int. 2005;25:445
- Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J. 1998;17:5588
- Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice. Am J Pathol. 1998;153:639
- Massive liver growth in mice induced by systemic interleukin 6 administration. Hepatology. 2003;38:326
- Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem. 1999;274:23013
- Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 1988;332:83
- Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1. Oncogene. 1999;18:3742
- Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett. 1989;250:607
- Inhibition of growth of human hepatoma cells by dual-function antisense IL-6 oligonucleotides. Hepatol Res. 2002;22:119
- . Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells. Mol Cell Biol. 1999;19:5326
- Oncostatin M and interleukin 6 inhibit cell cycle progression by prevention of p27kip1 degradation in HepG2 cells. Oncogene. 2000;19:3675
- Microencapsulation of engineered cells to deliver sustained high circulating levels of interleukin-6 to study hepatocellular carcinoma progression. Cell Transplant. 2006;15:785
- . Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol. 2004;5:836
- Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science. 1996;274:1379
- Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterol. 2003;3:19
- Role of MAP kinases and their cross-talk in TGF-beta1-induced apoptosis in FaO rat hepatoma cell line. Hepatology. 2002;35:1360
- Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci USA. 1998;95:11107
- . Receptor recognition by gp130 cytokines. EMBO J. 2000;19:2399
- . Principles of CDK regulation. Nature. 1995;374:131
- . CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13:1501
- Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines (A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells). J Biol Chem. 1998;273:21137
- Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J Exp Med. 2001;194:189
- Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1. J Biol Chem. 2004;279:1956
- BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells. Oncogene. 2001;20:7352
- . STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP. Prostate. 2000;42:88
- Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma. Oncogene. 1999;18:1023
- . Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression.[erratum appears in J Cell Biol 1993 Apr;121:following 477]. J Cell Biol. 1993;120:1281
- Growth inhibition of human lung cancer cell lines by interleukin 6 in vitro: a possible role in tumor growth via an autocrine mechanism. Cancer Res. 1993;53:4175
- . Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer (Malignant melanoma as a paradigm). Am J Pathol. 1992;141:519
- . Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression. Proc Natl Acad Sci USA. 1992;89:9215
PII: S0022-4804(07)00279-X
doi: 10.1016/j.jss.2007.04.022
© 2008 Elsevier Inc. All rights reserved.
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Journal of Surgical Research
Volume 147, Issue 1
, Pages 23-33
, 1 June 2008
