Journal of Surgical Research
Volume 142, Issue 2 , Pages 233-238 , October 2007

A Comparative Analysis Between Survivors and Nonsurvivors with Antibody Mediated Cardiac Allograft Rejection

  • Gonzalo V. Gonzalez-Stawinski, M.D.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, F24, Cleveland, Ohio 44195.
    • ,
  • Daniel J. Cook, Ph.D.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Jorge Chui

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Sandeep Gupta

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Jose L. Navia, M.D.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Katherine Hoercher

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • David O. Taylor, M.D.

      Affiliations

    • Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Mohamed H. Yamani

      Affiliations

    • Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Randall C. Starling, M.D.

      Affiliations

    • Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Nicholas G. Smedira, M.D.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio

Received 18 December 2006

References 

  1. Michaels PJ, Espejo ML, Kobashigawa J, et al. Humoral rejection in cardiac transplantation: Risk factors, hemodynamic consequences and relationship to transplant coronary artery disease. J Heart Lung Transplant. 2003;22:58
  2. Olsen SL, Wagoner LE, Hammond EH, et al. Vascular rejection in heart transplantation: Clinical correlation, treatment options, and future considerations. J Heart Lung Transplant. 1993;12:S135
  3. Behr TM, Feucht HE, Richter K, et al. Detection of humoral rejection in human cardiac allografts by assessing the capillary deposition of complement fragment C4d in endomyocardial biopsies. J Heart Lung Transplant. 1999;18:904
  4. Herskowitz A, Soule LM, Ueda K, et al. Arteriolar vasculitis on endomyocardial biopsy: A histologic predictor of poor outcome in cyclosporine-treated heart transplant recipients. J Heart Transplant. 1987;6:127
  5. Hammond EH, Yowell RL, Nunoda S, et al. Vascular (humoral) rejection in heart transplantation: Pathologic observations and clinical implications. J Heart Transplant. 1989;8:430
  6. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710
  7. Reed EF, Demetris AJ, Hammond E, et al. Acute antibody-mediated rejection of cardiac transplants. J Heart Lung Transplant. 2006;25:153
  8. Cook DJ, Klingman LL, Koo AP, et al. Quantitative flow cytometry cross-matching for precise measurement of donor-specific alloreactivity. Transplant Proc. 1994;26:2866
  9. Hammond EH, Hansen JK, Spencer LS, et al. Immunofluorescence of endomyocardial biopsy specimens: Methods and interpretation. J Heart Lung Transplant. 1993;12:S113
  10. Taylor DO, Yowell RL, Kfoury AG, et al. Allograft coronary artery disease: Clinical correlations with circulating anti-HLA antibodies and the immunohistopathologic pattern of vascular rejection. J Heart Lung Transplant. 2000;19:518
  11. Miller LW, Wesp A, Jennison SH, et al. Vascular rejection in heart transplant recipients. J Heart Lung Transplant. 1993;12:S147
  12. Gupta S, Cook DJ, Sharma M, et al. Virtual Cross-match allows the expansion of effective donor pool for HLA sensitized patients. J Heart Lung Transplant. 2006;25:140
  13. Barr ML, Cohen DJ, Benvenisty AI, et al. Effect of anti-HLA antibodies on the long-term survival of heart and kidney allografts. Transplant Proc. 1993;25:262
  14. Girnita AL, McCurry KR, Iacono AT, et al. HLA-specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejection. J Heart Lung Transplant. 2004;23:1135
  15. Hammond EH, Ensley RD, Yowell RL, et al. Vascular rejection of human cardiac allografts and the role of humoral immunity in chronic allograft rejection. Transplant Proc. 1991;23(2 Suppl 2):26
  16. Rahimi S, Qian Z, Layton J, et al. Noncomplement- and complement-activating antibodies synergize to cause rejection of cardiac allografts. Am J Transplant. 2004;4:326
  17. Reed E, Ho E, Cohen DJ, et al. Anti-idiotypic antibodies specific for HLA in heart and kidney allograft recipients. Immunol Res. 1993;12:1
  18. Hammond EH, Yowell RL, Price GD, et al. Vascular rejection and its relationship to allograft coronary artery disease. J Heart Lung Transplant. 1992;11:S111
  19. Costanzo-Nordin MR, Heroux AL, Radvany R, et al. Role of humoral immunity in acute cardiac allograft dysfunction. J Heart Lung Transplant. 1993;12:S143
  20. Lones MA, Czer LS, Trento A, et al. Clinical-pathologic features of humoral rejection in cardiac allografts: A study in 81 consecutive patients. J Heart Lung Transplant. 1995;14:151
  21. Scoazec JY, Delautier D, Moreau A, et al. Expression of complement-regulatory proteins in normal and UW-preserved human liver. Gastroenterology. 1994;107:505
  22. Yamada K, Miwa T, Liu J, et al. Critical protection from renal ischemia reperfusion injury by CD55 and CD59. J Immunol. 2004;172:3869
  23. Chen RH, Naficy S, Logan JS, et al. Hearts from transgenic pigs constructed with CD59/DAF genomic clones demonstrate improved survival in primates. Xenotransplantation. 1999;6:194
  24. McCurry KR, Kooyman DL, Alvarado CG, et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med. 1995;1:423

PII: S0022-4804(07)00314-9

doi: 10.1016/j.jss.2007.04.023

Journal of Surgical Research
Volume 142, Issue 2 , Pages 233-238 , October 2007

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