« Previous
Next »
Journal of Surgical Research
Volume 146, Issue 1
, Pages 16-23
, 1 May 2008
Inhibition of In Vivo Tumor Angiogenesis and Growth Via Systemic Delivery of an Angiopoietin 2-Specific RNA Aptamer
References
- Vascular-specific growth factors and blood vessel formation. Nature. 2000;407:242
- Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992;7:1471
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 1995;376:70
- Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994;8:1897
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell. 1996;87:1161
- Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J Clin Invest. 2002;110:1619
- Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science. 1999;286:2511
- Requisite role of angiopoietin-1, a ligand for the Tie2 receptor, during embryonic angiogenesis. Cell. 1996;87:1171
- . Angiopoietin-2, a natural antagonist for Tie2 that disrupts n vivo angiogenesis. Science. 1997;277:55
- Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science. 1999;284:1994
- . Angiopoietin-2 displays the VEGF-dependent modulation of capillary structure and endothelial survival in vivo. Proc Natl Acad Sci. 2002;99:11205
- Blood vessel maturation in a 3-dimensional spheroidal co-culture model: Direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness. FASEB J. 2001;15:447
- . Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci. 2002;99:8219
- Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell. 2002;3:411
- Inhibition of tumor angiogenesis using a solube receptor establishes a role for Tie2 in pathological vascular growth. J Clin Invest. 1997;100:2072
- Differential inhibition of tumor angiogenesis by Tie2 and vascular endothelial growth factor receptor-2 dominant-negative receptor mutants. Int J Cancer. 2001;91:273
- Systemically expressed soluble Tie2 inhibits intraocular neovascularization. Hum Gene Ther. 2001;12:1311
- Anti-angiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. Proc Natl Acad Sci. 1998;95:8829
- . Two independent mechanisms essential for tumor angiogenesis: Inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. Cancer Res. 1999;59:3185
- Expression and function of angiopoietin-1 in breast cancer. Br J Cancer. 2000;83:1154
- Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest. 1999;103:341
- The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. Cancer Res. 2001;61:1255
- Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer. Cancer Res. 2003;63:3403
- Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. Proc Natl Acad Sci. 2003;100:5028
- Noninvasive visualization of tumors in rodent dorsal skin window chambers: A novel model for evaluating anti-cancer therapies. Nat Biotech. 1999;17:1033
- . Aptamers as therapeutic and diagnostic agents. Rev Mol Biotech. 2000;74:5
- . Aptamers as therapeutic and diagnostic reagents: Problems and prospects. Curr Opin Chem Biol. 1997;1:5
- Highly specific anti-angiogenic therapy is effective in suppressing growth of experimental Wilms tumors. J Pediatr Surg. 2001;36:357
- Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci. 2002;99:11399
- Novel approach to specific growth factor inhibition in vivo: Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am J Pathol. 1999;154:169
- VEGF165 mediates glomerular endothelial repair. J Clin Invest. 1999;104:913
- . Emerging clinical applications of RNA. Nature. 2002;418:252
- . Escort aptamers: A delivery service for diagnosis and therapy. J Clin Invest. 2002;106:923
- . Developing aptamers into therapeutics. J Clin Invest. 2000;106:929
- Kinetic characterization of ribonuclease-resistant 2′-modified hammer-head ribozymes. Science. 1991;253:314
- Chemical modification of hammerhead ribozymes (Catalytic activity and nuclease resistance). J Biol Chem. 1995;270:25702
- Liposome-anchored vascular endothelial growth factor aptamers. Bioconj Chem. 1998;9:573
- . Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina. 2002;22:143
- . Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: Phase II study results. Ophthalmology. 2003;110:979
- Initial stages of tumor cell-induced angiogenesis: Evaluation via skin window chambers in rodent models. J Natl Cancer Inst. 2000;92:143
- Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell. 2004;6:507
- Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res. 2003;63:3370
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335
PII: S0022-4804(07)00319-8
doi: 10.1016/j.jss.2007.04.028
© 2008 Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Surgical Research
Volume 146, Issue 1
, Pages 16-23
, 1 May 2008
