Journal of Surgical Research
Volume 146, Issue 1 , Pages 66-72 , 1 May 2008

Prostaglandin E1 Improves Survival Rate After 95% Hepatectomy in Rats

  • Shinji Togo, M.D., F.A.C.S.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
    • ,
  • Haochuan Chen, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Takuji Takahashi, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Toru Kubota, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Kenichi Matsuo, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Daisuke Morioka, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Kazuteru Watanabe, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Harumi Yamamoto, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Yoji Nagashima, M.D.

      Affiliations

    • Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    • ,
  • Hiroshi Shimada, M.D.

      Affiliations

    • Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Received 20 January 2007

References 

  1. Takahashi T, Togo S, Tanaka K, et al. Safe and permissible limits of hepatectomy in obstructive jaundice patients. World J Surg. 2004;28:475
  2. Kubota T, Takabe K, Yang M, et al. Minimum sizes for remnant and transplanted livers in rat. J Hepatolbil Pancreat Surg. 1997;4:398
  3. Matsuo K, Togo S, Sekido H, et al. Pharmacological preconditioning effects: Prostaglandin E1 induces heat-shock proteins immediately after ischemia/reperfusion of the mouse liver. J Gastrointest Surg, in press.
  4. Tuczek HV, Rabes H. Verlust der Proliferatuionsfahigkeit der Hepatozyten nach subtotalen Hepatectomie. Experientia. 1971;27:526
  5. Emond J, Capron-Laudereay M, Meriggi F, et al. Extent of hepatectomy in the rat: Evaluation of basal condition and effect of therapy. Eur Surg Res. 1989;21:251
  6. Morita T, Togo S, Kamimukai N, et al. Mechanism of postoperative liver failure after excessive hepatectomy investigated using cDNA micoarray. J Hepatolbil Pancreat Surg. 2002;9:352
  7. Abecassis M, Falk JA, Makowka L, et al. 16,16,Dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection. J Clin Invest. 1987;80:881
  8. Greig PD, Woolf GM, Sinclair SB, et al. Treatment of primary liver graft nonfunction with prostaglandin E1. Transplantation. 1989;48:447
  9. Weiner R, Kaley G. Influence of prostaglandin E1 on the terminal vascular bed. Am J Physiol. 1969;217:563
  10. Nakano J, Cole B. Effect of prostaglandin E and F on systemic, pulmonary, and splanchnic circulation in dogs. Am J Physiol. 1969;17:222
  11. Robert A. Cytoprotection by prostaglandins. Gastroenterology. 1979;77:761
  12. Kurosawa H, Shimada H, Nakano A, et al. The role of intracellular calcium in the production of superoxide anion by Kupffer cells stimulated by lipopolysaccharide and the efficacy of prostaglandin E1. Int Hepatol Commun. 1996;4:326
  13. Natori S, Fujii Y, Kurosawa H, et al. Prostaglandin E1 protects against ischemia-reperfusion injury of the liver by inhibition of neutrophil adherence to endothelial cells. Transplantation. 1997;64:1514
  14. Ando K, Miyazaki M, Shimizu H, et al. Beneficial effects of prostaglandin E1 incorporated in lipid microspheres on liver injury and regeneration after 90% partial hepatectomy in rats. Eur Surg Res. 2000;32:155
  15. Lindquist S. The heat shock response. Ann Rev Biochem. 1986;55:1151
  16. Welch WJ. Mammalian stress response: Cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol Rev. 1992;72:1063
  17. Nishihara M, Sumimoto R, Fukuda Y, et al. TNF-α and heat-shock protein gene expression in ischemic-injured liver from fasted and non-fasted rats (Role of donor fasting in the prevention of reperfusion injury following liver transplantation). Transpl Int. 1998;11:S417
  18. Yamamoto Y, Kume M, Yamaoka Y. Implications of heat shock proteins during liver surgery and liver perfusion. Recent Results Cancer Res. 1998;147:157
  19. Miyoshi H, Gores GJ. Apoptosis and the liver: Relevance for the hepatobiliary-pancreatic surgeon. J Hepatobil Pancreat Surg. 1998;5:409
  20. Beere HM, Wolf BB, Cain K, et al. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol. 2000;2:469
  21. Pandey P, Saleh A, Nakazawa A, et al. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J. 2000;19:4310
  22. Tanaka K, Shimada H, Togo S, et al. Outcome using hemivascular occlusion versus the Pringle maneuver in resections limited to one hepatic section or less. J Gastrointestinal Surg, in press.

PII: S0022-4804(07)00352-6

doi: 10.1016/j.jss.2007.05.003

Journal of Surgical Research
Volume 146, Issue 1 , Pages 66-72 , 1 May 2008

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