Journal of Surgical Research
Volume 146, Issue 2 , Pages 218-224 , 15 May 2008

Postischemic Infusion of 17-β-Estradiol Protects Myocardial Function and Viability

  • Andrew M. Terrell, B.A.

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Paul R. Crisostomo, M.D.

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall 203, Indianapolis, IN 46202.
  • ,
  • Troy A. Markel, M.D.

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Meijing Wang, M.D., M.S.

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Aaron M. Abarbanell, M.D.

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Jeremy L. Herrmann, M.D.

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Daniel R. Meldrum, M.D.

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
    • Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana
    • Center for Immunobiology, Indiana University School of Medicine, Indianapolis, Indiana

Received 20 February 2007

References 

  1. Matsumura K, Jeremy RW, Schaper J, et al. Progression of myocardial necrosis during reperfusion of ischemic myocardium. Circulation. 1998;97:795
  2. Meldrum DR. Tumor necrosis factor in the heart. Am J Physiol. 1998;274:R577
  3. Vaccarino V, Krumholz HM, Berkman LF, et al. Sex differences in mortality after myocardial infarction (Is there evidence for an increased risk for women?). Circulation. 1995;91:1861
  4. Kher A, Wang M, Tsai BM, et al. Sex differences in the myocardial inflammatory response to acute injury. Shock. 2005;23:1
  5. Yang S, Choudhry MA, Hsieh YC, et al. Estrus cycle: Influence on cardiac function following trauma-hemorrhage. Am J Physiol Heart Circ Physiol. 2006;291:H2807
  6. Wang M, Tsai BM, Crisostomo PR, et al. Tumor necrosis factor receptor-1 signaling resistance in the female myocardium during ischemia. Circulation. 2006;114:I282
  7. Ramani R, Mathier M, Wang P, et al. Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling. Am J Physiol Heart Circ Physiol. 2004;287:H1369
  8. Cavasin MA, Tao Z, Menon S, et al. Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice. Life Sci. 2004;75:2181
  9. Cain BS, Meldrum DR, Dinarello CA, et al. Tumor necrosis factor-α and interleukin-1β synergistically depress human myocardial function. Crit Care Med. 1999;27:1309
  10. Cain BS, Meldrum DR, Meng X, et al. p38 MAPK inhibition decreases TNF-α production and enhances postischemic human myocardial function. J Surg Res. 1999;83:7
  11. Meldrum DR, Dinarello CA, Shames BD, et al. Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-α production (Potential ultimate effector mechanism of preconditioning). Circulation. 1998;98:II214;discussion II218
  12. Wang M, Baker L, Tsai BM, et al. Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury. Am J Physiol Endocrinol Metab. 2005;288:E321
  13. Xu Y, Arenas IA, Armstrong SJ, et al. Estrogen improves cardiac recovery after ischemia/reperfusion by decreasing tumor necrosis factor-α. Cardiovasc Res. 2006;69:836
  14. Delyani JA, Murohara T, Nossuli TO, et al. Protection from myocardial reperfusion injury by acute administration of 17-β-estradiol. J Mol Cell Cardiol. 1996;28:1001
  15. Hale SL, Birnbaum Y, Kloner RA. β-Estradiol, but not α-estradiol, reduced myocardial necrosis in rabbits after ischemia and reperfusion. Am Heart J. 1996;132:258–262
  16. Booth EA, Marchesi M, Kilbourne EJ, et al. 17-β-Estradiol as a receptor-mediated cardioprotective agent. J Pharmacol Exp Ther. 2003;307:395
  17. Node K, Kitakaze M, Kosaka H, et al. Amelioration of ischemia- and reperfusion-induced myocardial injury by 17-β-estradiol: Role of nitric oxide and calcium-activated potassium channels. Circulation. 1997;96:1953
  18. Wang M, Crisostomo P, Wairiuko GM, et al. Estrogen receptor-α mediates acute myocardial protection in females. Am J Physiol Heart Circ Physiol. 2006;290:H2204
  19. Zhai P, Eurell TE, Cooke PS, et al. Myocardial ischemia-reperfusion injury in estrogen receptor-α knockout and wild-type mice. Am J Physiol Heart Circ Physiol. 2000;278:H1640
  20. Mizushima Y, Wang P, Jarrar D, et al. Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals. Ann Surg. 2000;232:673
  21. Suzuki T, Shimizu T, Yu HP, et al. 17-β-Estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-α. Surgery. 2006;140:141
  22. Sener G, Arbak S, Kurtaran P, et al. Estrogen protects the liver and intestines against sepsis-induced injury in rats. J Surg Res. 2005;128:70
  23. Erikoglu M, Sahin M, Ozer S, et al. Effects of gender on the severity of sepsis. Surg Today. 2005;35:467
  24. Schaff HV, Gott VL, Goldman RA, et al. Mechanism of elevated left ventricular end-diastolic pressure after ischemic arrest and reperfusion. Am J Physiol. 1981;240:H300
  25. Feng NC, Satoh H, Urushida T, et al. A selective inhibitor of Na+/Ca2+ exchanger, SEA0400, preserves cardiac function and high-energy phosphates against ischemia/reperfusion injury. J Cardiovasc Pharmacol. 2006;47:263
  26. Lu C, Minatoguchi S, Arai M, et al. Nicorandil improves postischemic myocardial dysfunction in association with opening the mitochondrial K(ATP) channels and decreasing hydroxyl radicals in isolated rat hearts. Circ J. 2006;70:1650
  27. Wang M, Sankula R, Tsai BM, et al. P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression. Shock. 2004;21:170
  28. Moritz A, Radtke OA, Gust R, et al. Characterization of the relaxant response to raloxifene in porcine coronary arteries. Eur J Pharmacol. 2006;545:153
  29. Zhao ZQ. Oxidative stress-elicited myocardial apoptosis during reperfusion. Curr Opin Pharmacol. 2004;4:159
  30. McHugh NA, Merrill GF, Powell SR. Estrogen diminishes postischemic hydroxyl radical production. Am J Physiol. 1998;274:H1950
  31. Kim JK, Pedram A, Razandi M, et al. Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J Biol Chem. 2006;281:6760
  32. Camper-Kirby D, Welch S, Walker A, et al. Myocardial Akt activation and gender: Increased nuclear activity in females versus males. Circ Res. 2001;88:1020
  33. Kim YD, Farhat MY, Myers AK, et al. 17-β-estradiol regulation of myocardial glutathione and its role in protection against myocardial stunning in dogs. J Cardiovasc Pharmacol. 1998;32:457
  34. Urata Y, Ihara Y, Murata H, et al. 17-β-Estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. J Biol Chem. 2006;281:13092
  35. Morkuniene R, Arandarcikaite O, Borutaite V. Estradiol prevents release of cytochrome c from mitochondria and inhibits ischemia-induced apoptosis in perfused heart. Exp Gerontol. 2006;41:704
  36. Hsieh YC, Yu HP, Suzuki T, et al. Up-regulation of mitochondrial respiratory complex IV by estrogen receptor-β is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage. J Mol Cell Cardiol. 2006;41:511
  37. Pelzer T, Schumann M, Neumann M, et al. 17-β-Estradiol prevents programmed cell death in cardiac myocytes. Biochem Biophys Res Commun. 2000;268:192
  38. Pelzer T, Neumann M, de Jager T, et al. Estrogen effects in the myocardium: Inhibition of NF-κB DNA binding by estrogen receptor-α and -β. Biochem Biophys Res Commun. 2001;286:1153
  39. Suzuki T, Shimizu T, Yu HP, et al. Tissue-compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage. J Appl Physiol. 2006;

1 Andrew M. Terrell and Paul R. Crisostomo contributed equally to this work.

PII: S0022-4804(07)00373-3

doi: 10.1016/j.jss.2007.05.021

Journal of Surgical Research
Volume 146, Issue 2 , Pages 218-224 , 15 May 2008