Journal of Surgical Research
Volume 146, Issue 2 , Pages 164-171 , 15 May 2008

Biliary-Type Cytokeratin Pattern in a Canine Isolated Perfused Liver Transplantation Model

  • Consolato Sergi, M.D., Ph.D.

      Affiliations

    • Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria
    • Department of Pediatric Pathology, University of Bristol, Bristol, United Kingdom
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Institute of Pathology, Medical University of Innsbruck, Muellerstrasse 44, A-6020 Innsbruck, Austria.
    • ,
  • Wolfgang Gross, Ph.D., C.Stat.

      Affiliations

    • Department of Experimental Surgery, Heidelberg Medical University, Heidelberg, Germany
    • ,
  • Martin Mory, M.D.

      Affiliations

    • Department of Experimental Surgery, Heidelberg Medical University, Heidelberg, Germany
    • ,
  • Michael Schaefer, Ph.D.

      Affiliations

    • Department of Experimental Surgery, Heidelberg Medical University, Heidelberg, Germany
    • ,
  • Martha-Maria Gebhard, M.D., Ph.D.

      Affiliations

    • Department of Experimental Surgery, Heidelberg Medical University, Heidelberg, Germany

Received 2 February 2007

References 

  1. Clavien PA, Harvey PR, Strasberg SM. Preservation and reperfusion injuries in liver allografts (An overview and synthesis of current studies). Transplantation. 1992;53:957
  2. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg. 2001;181:160
  3. Kukan M, Haddad PS. Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts. Liver Transpl. 2001;7:381
  4. Ott P. Hepatic elimination of indocyanine green with special reference to distribution kinetics and the influence of plasma protein binding. Pharmacol Toxicol. 1998;83(Suppl):1
  5. Yasui H, Yoshimura N, Kobayashi Y, et al. Microstructural changes of bile canaliculi in canine liver: The effect of cold ischemia-reperfusion in orthotopic liver transplantation. Transplant Proc. 1998;30:3754
  6. Shinohara H, Tanaka A, Kitai T, et al. Direct measurement of hepatic indocyanine green clearance with near-infrared spectroscopy: Separate evaluation of uptake and removal. Hepatology. 1996;23:137
  7. Oude Elferink RP, Frijters CM, Paulusma C, et al. Regulation of canalicular transport activities. J Hepatol. 1996;24(Suppl):94
  8. Kullak-Ublick GA, Beuers U, Paumgartner G. Hepatobiliary transport. J Hepatol. 2000;32:3
  9. Keppler D, Konig J. Hepatic secretion of conjugated drugs and endogenous substances. Semin Liver Dis. 2000;20:265
  10. Shinohara H, Tanaka A, Fujimoto T, et al. Disorganization of microtubular network in postischemic liver dysfunction: Its functional and morphological changes. Biochim Biophys Acta. 1996;1317:27
  11. Haussinger D, Schmitt M, Weiergraber O, Kubitz R. Short-term regulation of canalicular transport. Semin Liver Dis. 2000;20:307
  12. Rauen U, Reuters I, Fuchs A, et al. Oxygen-free radical-mediated injury to cultured rat hepatocytes during cold incubation in preservation solutions. Hepatology. 1997;26:351
  13. Jaeschke H. Preservation injury: Mechanisms, prevention, and consequences. J Hepatol. 1996;25:774
  14. Vajdova K, Graf R, Clavien PA. ATP supplies in the cold-preserved liver: A long-neglected factor of organ viability. Hepatology. 2002;36:1543
  15. St Peter SD, Imber CJ, Friend PJ. Liver and kidney preservation by perfusion. Lancet. 2002;359:604

1 Consolato Sergi and Martin Mory contributed equally to this work.

2 Preliminary data of this paper were presented in part at the Annual Meeting of the Pathological Society of Great Britain and Ireland, Newcastle upon Tyne, United Kingdom, 4th-7th July 2005 (J Pathol Suppl July 2005).

PII: S0022-4804(07)00376-9

doi: 10.1016/j.jss.2007.05.024

Journal of Surgical Research
Volume 146, Issue 2 , Pages 164-171 , 15 May 2008

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