Journal of Surgical Research
Volume 145, Issue 2 , Pages 199-204 , April 2008

Nicotine at a Low Concentration Promotes Wound Healing

  • Naoki Morimoto, M.D.

      Affiliations

    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
  • ,
  • Satoru Takemoto, M.D.
  • ,
  • Takeshi Kawazoe, M.D.
  • ,
  • Shigehiko Suzuki, M.D.

Received 29 August 2006

References 

  1. Selber JC, Kurichi JE, Vega SJ, et al. Risk factors and complications in free TRAM flap breast reconstruction. Ann Plast Surg. 2006;56:429
  2. Spear SL, Ducic I, Cuoco F, et al. The effect of smoking on flap and donor-site complications in pedicled TRAM breast reconstruction. Plast Reconst Surg. 2005;116:1873
  3. Sorensen LT, Hemmingsen U, Kallehave F, et al. Risk factors for tissue and wound complications in gastrointestinal surgery. Ann Surg. 2005;241:654
  4. Sorensen LT, Karlsmark T, Gottrup F. Abstinence from smoking reduces incisional wound infection: a randomized controlled trial. Ann Surg. 2003;238:1
  5. Misery L. Nicotine effects on skin: are they positive or negative?. Exp Dermatol. 2004;13:665
  6. Silverstein P. Smoking and wound healing. Am J Med. 1992;15:22S
  7. Wong LS, Green HM, Feugate JE, et al. Effects of “second-hand” smoke on structure and function of fibroblasts, cells that are critical for tissue repair and remodeling. BMC Cell Biol. 2004;5:13
  8. Sherwin MA, Gastwirth CM. Detrimental effects of cigarette smoking on lower extremity wound healing. J Foot Surg. 1990;29:84
  9. Fang Y, Svoboda KK. Nicotine inhibits human gingival fibroblast migration via modulation of Rac signalling pathways. J Clin Periodontol. 2005;32:1200
  10. Heeschen C, Jang JJ, Weis M, et al. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med. 2001;7:833
  11. Heeschen C, Weis M, Cooke JP, et al. Nicotine promotes arteriogenesis. J Am Coll Cardiol. 2003;41:489
  12. Villablanca AC. Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol. 1998;84:2089
  13. Cooke JP, Bitterman H. Nicotine and angiogenesis: a new paradigm for tobacco-related diseases. Ann Med. 2004;26:33
  14. Jacobi J, Jang JJ, Sundram U, et al. Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Am J Pathol. 2002;161:97
  15. McGee GS, Davidson JM, Buckley A, et al. Recombinant basic fibroblast growth factor accelerates wound healing. J Surg Res. 1988;45:145
  16. Gospodarowicz D, Ferrara N, Schweigerer L, et al. Structural characterization and biological functions of fibroblast growth factor. Endocr Rev. 1987;8:95
  17. Yamanaka K, Inaba T, Nomura E, et al. Basic fibroblast growth factor treatment for skin ulcerations in scleroderma. Cutis. 2005;76:373
  18. Hill P, Haley NJ, Wynder EL. Cigarette smoking: carboxyhemoglobin, plasma nicotine, cotinine and thiocyanate vs. self-reported smoking data and cardiovascular disease. J Chronic Dis. 1983;36:439
  19. Henninifield JE, Stapleton JM, Benowitz NL, et al. Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend. 1993;33:23
  20. Natori T, Sata M, Washida M, et al. Nicotine enhances neovascularization and promotes tumor growth. Mol Cells. 2003;16:143
  21. Zhu BQ, Heeschen C, Sievers RE, et al. Second hand smoke stimulates tumor angiogenesis and growth. Cancer Cell. 2003;4:191
  22. Hogg RC, Bertrand D. Nicotinic acetylcholine receptors as drug targets. Neurol Disord. 2004;3:123

PII: S0022-4804(07)00384-8

doi: 10.1016/j.jss.2007.05.031

Journal of Surgical Research
Volume 145, Issue 2 , Pages 199-204 , April 2008