Journal of Surgical Research
Volume 147, Issue 1 , Pages 15-22 , 1 June 2008

Folate Stimulation of Wound DNA Synthesis

Received 18 March 2007

References 

  1. Lewis B. Nutrition and wound healing. In:  Kloth LC,  McCulloch JM editor. Wound Healing: Alternatives in management. Philadelphia: F. A. Davis Co.; 2002;p. 35–62
  2. Cuthberson DP, Fell GS, Smith CM, et al. Nutrition in the post-traumatic period. Nutr Metab. 1972;14(Suppl):92
  3. Wilmore DW. Metabolic changes in burns. In:  Artz CP,  Moncrief JA,  Pruitt BA editor. Burns—A Team Approach. Philadelphia: W. B. Saunders; 1979;p. 120
  4. Hildreth M, Gottschlich M. Nutritional support of the burned patient. In:  Herndon DN editors. Total Burn Care. Philadelphia: W. B. Saunders; 1996;p. 237
  5. Kiyama T, Efron DT, Tantry U, et al. Trauma and wound healing: Role of the route of nutritional support. Int J Surg Invest. 2001;2:483
  6. Waitzberg DL, Plopper C, Terra RM. Postoperative total parenteral nutrition. World J Surg. 1999;23:560
  7. Chiarelli A, Enzi G, Casadei A, et al. Very early nutrition supplementation in burned patient. Am J Clin Nutr. 1990;51:1035
  8. Saito H, Trocki O, Alexander JW, et al. The effect of route of nutrient administration on the nutritional state, catabolic hormonal secretion, and gut mucosal integrity after burn injury. J Parenter Enteral Nutr. 1987;11:1
  9. Mochizuki H, Trocki O, Dominioni L, et al. Mechanism of prevention of postburn hypermetabolism and catabolism by early enteral feeding. Ann Surg. 1984;200:297
  10. Zhang X-J, Chinkes DL, Wolfe RR. The flow phase of wound metabolism is characterized by stimulated protein synthesis rather than cell proliferation. J Surg Res. 2006;135:61
  11. Zhang X-J, Chinkes DL, Wolf SE, et al. Insulin but not growth hormone has an anabolic effect on protein metabolism in scalded skin and muscle. Am J Physiol Endocrinol Metab. 1999;276:E712
  12. Zhang X-J, Chinkes DL, Irtun Ø, et al. Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids. Am J Physiolol Endocrinol Metab. 2002;282:1308
  13. Zhang X-J, Chinkes DL, Wolfe RR. Leucine supplementation has an anabolic effect on proteins in rabbit skin wound and muscle. J Nutr. 2004;134:3313
  14. Zhang X-J, Heggers JP, Chinkes DL, et al. Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site wound. Surgery. 2006;139:633–639
  15. Zhang X-J, Chinkes DL, Wu Z, et al. Fractional synthesis rates of DNA and protein do not correlate in rabbit skin. J Nutr. 2004;134:2401
  16. Wolfe RR, Chinkes DL. Isotopic Tracers in Metabolic Research: Principle and practice of kinetic analysis. In: 2nd ed.. New Jersey: Wiley-Liss; 2004;p. 215–257325–360
  17. Neese RA, Siler SQ, Cesar D, et al. Advances in the stable isotope-mass spectrometric measurement of DNA synthesis and cell proliferation. Anal Biochem. 2001;298:189
  18. Nissim I, Starr Se, Sullivan KE, et al. Rapid method for determining the rate of DNA synthesis and cellular proliferation. Anal Biochem. 2000;278:198
  19. Phillips SM, Tipton KD, Aarsland A, et al. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol. 1997;273:E99
  20. Patterson BW, Zhang X-J, Chen Y, et al. Measurement of very low stable isotope enrichment by gas chromatography/mass spectrometry: Application to measurement of muscle protein synthesis. Metabolism. 1997;46:943
  21. Rosenblatt J, Chinkes DL, Wolfe MH, et al. Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects. Am J Physiol. 1992;263:E584
  22. Zhang X-J, Chinkes DL, Sakurai Y, et al. An isotopic method for measurement of muscle protein fractional breakdown rate in vivo. Am J Physiol. 1996;270:E759
  23. Volpi E, Jeschke MG, Herndon DN, et al. Measurement of skin protein breakdown in a rat model. Am J Physiol Endocrinol Metab. 2000;279:E900
  24. Zhang X-J, Chinkes DL, Wolfe RR. Local injection of insulin-zinc suspension stimulates DNA synthesis in skin donor wound. J Burn Care Rehab. 2005;26(Suppl):S102;Abstract 114
  25. Kim Y-I. Nutritional epigenetics: Impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr. 2005;135:2703
  26. Duthie SJ, Narayanan S, Sharp L, et al. Folate (DNA stability and colorectal neoplasia). Proc Nutr Soc. 2004;63:571
  27. Hu RH, Yu YM, Costa D, et al. A rabbit model for metabolic studies after burn injury. J Surg Res. 1998;75:153

PII: S0022-4804(07)00473-8

doi: 10.1016/j.jss.2007.07.012

Journal of Surgical Research
Volume 147, Issue 1 , Pages 15-22 , 1 June 2008

Article Tools

* Image Usage & Resolution