Journal of Surgical Research
Volume 148, Issue 2 , Pages 116-120 , August 2008

Inhibition of Lipopolysaccharide Activation of Kupffer Cells by Transition Metals

  • Peter Thomas, Ph.D.

      Affiliations

    • Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • Department of Surgery, Boston University School of Medicine, Boston, Massachusetts
    • Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Correspondence to: Creighton University, Criss III Research Building, Room 376, 2500 California Plaza, Omaha, NE 68178.
    • ,
  • Hiroshi Hayashi, M.D.

      Affiliations

    • Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • Department of Surgery, Boston University School of Medicine, Boston, Massachusetts
    • ,
  • Donald Lazure, M.S.

      Affiliations

    • Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • ,
  • Peter A. Burke, M.D.

      Affiliations

    • Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • Department of Surgery, Boston University School of Medicine, Boston, Massachusetts
    • ,
  • Olga Bajenova, Ph.D.

      Affiliations

    • Department of Surgery, Boston University School of Medicine, Boston, Massachusetts
    • Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska
    • ,
  • Aniruddha Ganguly, Ph.D.

      Affiliations

    • Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • ,
  • R. Armour Forse, M.D., Ph.D.

      Affiliations

    • Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • Department of Surgery, Boston University School of Medicine, Boston, Massachusetts
    • Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska

Received 11 December 2006

References 

  1. Glauser MP, Zanetti G, Baumgartner J-D, et al. Septic shock: Parthenogenesis. Lancet. 1991;338:732
  2. Fox ES, Broitman SA, Thomas P. Bacterial endotoxins and the liver. Lab Invest. 1990;63:733
  3. Su GL. Lipopolysaccharides in liver injury: Molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol. 2002;283:G256
  4. Toth CA, Thomas P. Hepatic endocytosis and Kupffer cells. Hepatology. 1992;16:255
  5. Bellezzo JM, Britton RS, Bacon BR, et al. LPS-mediated NF-kappa B activation in rat Kupffer cells can be induced independently of CD14. Am J Physiol Gastrointest Liver Physiol. 1996;270:G956
  6. Su GL, Rahemtulla A, Thomas P, et al. CD14 and lipopolysaccharide binding protein expression in experimental alcoholic liver disease. Am J Pathol. 1998;152:841
  7. Snyder SL, Walker RI, Moniot JV. Protection against endotoxin induced mortality in mice treated with transition metal salts. Infect Immun. 1977;15:337
  8. Snyder SL, Walker RI, MacVittie TJ, et al. Biologic properties of bacterial lipopolysaccharides treated with chromium chloride. Can J Microbiol. 1978;24:495
  9. Sobocinski PZ, Powanda MC, Canterbury WJ, et al. Role of zinc in the abatement of hepatocellular damage and mortality incidence in endotoxemic rats. Infect Immun. 1977;15:950
  10. Lambert JC, Zhou ZX, Wang LP, et al. Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice. J Pharm Exp Ther. 2003;305:880
  11. Ulevitch RJ. The preparation and characterization of a radio iodinated bacterial lipopolysaccharide. Immunochemistry. 1978;15:157
  12. Greenwood F, Hunter W, Glover J. The preparation of 125I-labelled human growth hormone of high specific radioactivity. Biochem J. 1963;89:114
  13. Toth CA, Thomas P, Broitman SA, et al. Receptor mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells. Cancer Res. 1985;45:392
  14. Thomas P, Lazure DA, Moussa R, et al. Endotoxin processing in Kupffer cells: Identification of two intracellular LPS-binding proteins. J Endotoxin Res. 2006;12:352
  15. Fox ES, Thomas P, Broitman SA. Comparative studies of endotoxin uptake by isolated rat Kupffer and peritoneal cells. Infect Immun. 1987;55:2962
  16. Treon SP, Thomas P, Broitman SA. Lipopolysaccharide processing by Kupffer cells releases a modified LPS with increased hepatocyte binding and decreased tumor necrosis factor-α stimulatory capacity. Proc Soc Exp Biol Med. 1993;202:153
  17. Filipov NM, Seegal RF, Lawrence DA. Manganese potentiates in vitro production of proinfammatory cytokines and nitric oxide by microgilia through a nuclear factor kappa B-dependent mechanism. Toxicol Sci. 2005;84:139
  18. Zhou Z, Wang L, Song Z, et al. Abrogation of nuclear factor 6B activation is involved in zinc inhibition of lipopolysaccharides-induced tumor necrosis factor—production and liver injury. Am J Pathol. 2004;164:1547
  19. Abou-Mohamed G, Papapetropoulos A, Catravas J, et al. Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: Implication in its anti-inflammatory activity. Eur J Pharmacol. 1998;341:265
  20. Tichy SJ. The influence of some cations on bacterial endotoxins: Copper. Z Bakteriol Parasit Infekt Und Hygiene. 1975;231:259
  21. Mandali SL, Stoecker BJ, Maxwell CV, et al. Endotoxin decreases 51CrCl3 uptake in early weaned pigs. Biol Trace Element Res. 2002;88:145
  22. Kaplanski J, Magazanik A, Hadas I, et al. Effects of lipopolysaccharides on body temperature and plasma zinc and iron concentrations in rats exposed to different ambient temperatures. J Thermal Biol. 2000;25:35
  23. Krones C, Klosterhaifen B, Fackeldey V, et al. Deleterious effect of zinc in a pig model of acute endotoxemia. J Invest Surg. 2004;17:249

PII: S0022-4804(07)02386-4

doi: 10.1016/j.jss.2007.11.726

Journal of Surgical Research
Volume 148, Issue 2 , Pages 116-120 , August 2008

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