Journal of Surgical Research
Volume 149, Issue 2 , Pages 278-286 , October 2008

Talactoferrin Stimulates Wound Healing With Modulation of Inflammation

Received 23 July 2007

References 

  1. Vorland LH. Lactoferrin: A multifunctional glycoprotein. APMIS. 1999;107:971
  2. Engelmayer J, Varadhachary A. Properties of recombinant human lactoferrin and potential application to enhance healing of diabetic wounds. Wounds. 2003;15:294
  3. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738
  4. Diegelmann RF, Evans MC. Wound healing: An overview of acute, fibrotic, and delayed healing. Front Biosci. 2004;9:283
  5. Moore K, Ruge F, Harding KG. T lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers. Br J Dermatol. 1997;137:188
  6. Loots MA, Lamme EN, Zeegelaar J, et al. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol. 1998;111:850
  7. Rosner K, Ross C, Karlsmark T, et al. Immunohistochemical characterization of the cutaneous cellular infiltrate in different areas of chronic leg ulcers. APMIS. 1995;103:293
  8. Herrick SE, Sloan P, McGurk M, et al. Sequential changes in histologic pattern and extracellular matrix deposition during the healing of chronic venous ulcers. Am J Pathol. 1992;141:1085
  9. Duraisamy Y, Slevin M, Smith N, et al. Effect of glycation on basic fibroblast growth factor induced angiogenesis and activation of associated signal transduction pathways in vascular endothelial cells: Possible relevance to wound healing in diabetes. Angiogenesis. 2001;4:277
  10. Claudy AL, Mirshahi M, Soria C, et al. Detection of undegraded fibrin and tumor necrosis factor-alpha in venous leg ulcers. J Am Acad Dermatol. 1991;25:623
  11. Sorimachi K, Akimoto K, Hattori Y, et al. Activation of macrophages by lactoferrin: Secretion of TNF-α, IL-8, and NO. Biochem Mol Biol Int. 1997;43:79
  12. Edde L, Hipolito RB, Hwang FF, et al. Lactoferrin protects neonatal rats from gut-related systemic infection. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1140
  13. Artym J, Zimecki M, Kruzel ML. Effects of lactoferrin on IL-6 production by peritoneal and alveolar cells in cyclophosphamide-treated mice. J Chemother. 2004;16:187
  14. Varadhachary A, Wolf JS, Petrak K, et al. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int J Cancer. 2004;111:398
  15. Montesinos MC, Gadangi P, Longaker M, et al. Wound healing is accelerated by agonists of adenosine A2 (G α s-linked) receptors. J Exp Med. 1997;186:1615
  16. Robson MC, Phillips TJ, Falanga V, et al. Randomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers. Wound Repair Regen. 2001;9:347
  17. Gentzkow GD, Iwasaki SD, Hershon KS, et al. Use of dermagraft, a cultured human dermis, to treat diabetic foot ulcers. Diabetes Care. 1996;19:350
  18. Tsuboi R, Shi CM, Rifkin DB, et al. A wound healing model using healing-impaired diabetic mice. J Dermatol. 1992;19:673
  19. Werner S, Breeden M, Hübner G, et al. Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J Invest Dermatol. 1994;103:469
  20. Sato Y, Ohshima T, Kondo T. Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing. Biochem Biophys Res Commun. 1999;265:194
  21. Wetzler C, Kampfer H, Pfeilschifter J, et al. Keratinocyte-derived chemotactic cytokines: Expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo. Biochem Biophys Res Commun. 2000;274:689
  22. Jackman SH, Yoak MB, Keerthy S, et al. Differential expression of chemokines in a mouse model of wound healing. Ann Clin Lab Sci. 2000;30:201
  23. Angele MK, Knoferl MW, Ayala A, et al. Trauma-hemorrhage delays wound healing potentially by increasing proinflammatory cytokines at the wound site. Surgery. 1999;126:279
  24. Goren I, Kampfer H, Podda M, et al. Leptin and wound inflammation in diabetic ob/ob mice: Differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes. 2003;52:2821
  25. Lyons TE, Miller MS, Serena T, et al. Talactoferrin α, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: A Phase I/II clinical study. Am J Surg. 2007;193:49
  26. Weiman JT. Clinical efficacy of becaplermin (rhPDGF-BB). Am J Surg. 1998;176(2A Suppl):74S
  27. Bakker K, Rauwerda JA, Schaper NC. Introduction. Diabetes Metab Res Rev. 2000;16(1 Suppl):S1
  28. LeFrock JL, Joseph WS. Bone and soft-tissue infections of the lower extremities in diabetics. Clin Podiatr Med Surg. 1995;12:87

PII: S0022-4804(07)02410-9

doi: 10.1016/j.jss.2007.12.754

Journal of Surgical Research
Volume 149, Issue 2 , Pages 278-286 , October 2008

Article Tools

* Image Usage & Resolution