Journal of Surgical Research
Volume 148, Issue 2 , Pages 121-125 , August 2008

An Interleukin-6-Neutralizing Antibody Prevents Cyclosporine-Induced Nephrotoxicity in Mice

  • Mark LaSpina, D.O.

      Affiliations

    • Department of Surgery, SUNY Upstate Medical University, St. Syracuse, New York
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Upstate Medical University Hospital, 750 E. Adams St., Syracuse, NY 13210.
    • ,
  • Sudipta Tripathi, Ph.D.

      Affiliations

    • Department of Surgery, SUNY Upstate Medical University, St. Syracuse, New York
    • ,
  • Louis A. Gatto, Ph.D.

      Affiliations

    • Department of Biological Sciences, SUNY Cortland, Cortland, New York
    • ,
  • David Bruch, M.S.

      Affiliations

    • Department of Surgery, SUNY Upstate Medical University, St. Syracuse, New York
    • ,
  • Kristopher G. Maier, Ph.D.

      Affiliations

    • Department of Surgery, SUNY Upstate Medical University, St. Syracuse, New York
    • ,
  • Dilip S. Kittur, M.D., Sc.D.

      Affiliations

    • Department of Surgery, SUNY Upstate Medical University, St. Syracuse, New York

Received 8 January 2007

References 

  1. Andriambeloson E, Pally C, Hengerer B, et al. Transplantation-induced endothelial dysfunction as studied in rat aorta allografts. Transplantation. 2001;72:1881–1889
  2. Menger MD, Vollmar B. Role of microcirculation in transplantation. Microcirculation. 2000;7:291–306
  3. Cailhier JF, Laplante P, Hebert MJ. Endothelial apoptosis and chronic transplant vasculopathy: Recent results, novel mechanisms. Am J Transplant. 2006;6:247–253
  4. Koskinen PK, Lemstrom KB, Hayry PJ. How cyclosporine modifies histological and molecular events in the vascular wall during chronic rejection of rat cardiac allografts. Am J Pathol. 1995;146:972–980
  5. Mercanoglu F, Turkmen A, Kocaman O, et al. Endothelial dysfunction in renal transplant patients is closely related to serum cyclosporine levels. Transplant Proc. 2004;36:1357–1360
  6. Morris ST, McMurray JJ, Rodger RS, et al. Endothelial dysfunction in renal transplant recipients maintained on cyclosporine. Kidney Int. 2000;57:1100–1106
  7. Wilasrusmee C, Da Silva M, Singh B, et al. A new in vitro model to study endothelial injury. J Surg Res. 2002;104:131–136
  8. Wilasrusmee C, Da Silva M, Singh B, et al. Morphological and biochemical effects of immunosuppressive drugs in a capillary tube assay for endothelial dysfunction. Clin Transplant. 2003;9(Suppl 17):6–12
  9. Wilasrusmee C, Da Silva M, Siddiqui J, et al. Role of endothelin-1 in microvascular dysfunction caused by cyclosporin A. J Am Coll Surg. 2003;196:584–591
  10. Wilasrusmee C, Ondocin P, Bruch D, et al. Amelioration of cyclosporin A effect on microvasculature by endothelin inhibitor. Surgery. 2003;134:384–389
  11. Wilasrusmee C, Shah G, Kittur S, et al. Signal transduction pathway in endothelial dysfunction. Surg Infect (Larchmt). 2004;5:9–14
  12. Hazzan M, Buob D, Labalette M, et al. Assessment of the risk of chronic allograft dysfunction after renal transplantation in a randomized cyclosporine withdrawal trial. Transplantation. 2006;82:657–662
  13. Nacar A, Kiyici H, Ogus E, et al. Ultrastructural examination of glomerular and tubular changes in renal allografts with cyclosporine toxicity. Ren Fail. 2006;28:543–547
  14. Oflaz H, Turkmen A, Kazancioglu R, et al. The effect of calcineurin inhibitors on endothelial function in renal transplant recipients. Clin Transplant. 2003;17:212–216
  15. Paul LC. Endothelial dysfunction, atherosclerosis and cyclosporine in renal transplantation. Neth J Med. 2001;59:1–3
  16. Ruiz JC, Campistol JM, Grinyo JM, et al. Early cyclosporine a withdrawal in kidney-transplant recipients receiving sirolimus prevents progression of chronic pathologic allograft lesions. Transplantation. 2004;78:1312–1318

PII: S0022-4804(07)02432-8

doi: 10.1016/j.jss.2007.12.786

Journal of Surgical Research
Volume 148, Issue 2 , Pages 121-125 , August 2008

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