Journal of Surgical Research
Volume 151, Issue 1 , Pages 55-61 , January 2009

Delayed Protective Effects of Hyperoxia Against Cardiac Arrhythmias and Infarction in Anesthetized Rats

  • Mansour Esmaili Dehaj, Ph.D.

      Affiliations

    • Research Center for Trauma, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • Department of Physiology, Yazd University of Medical Sciences, Yazd, Iran
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Physiology, Faculty of Medicine, Baqyatallah University of Medical Sciences, P.O. Box 19395/6558, Tehran, Iran
    • ,
  • Babak Baharvand, M.D.

      Affiliations

    • Division of Heart, Shohadaye Ashayer Hospital, Khoramabad, Iran
    • ,
  • Bahram Rasoulian, M.D., Ph.D.

      Affiliations

    • Research Center for Trauma, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • Department of Physiology and Pharmacology, Lorestan University of Medical Sciences, Khoramabad, Iran
    • ,
  • Mohsen Foadaddini, M.Sc.

      Affiliations

    • Department of Physiology and Biophysics, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • ,
  • Alireza Asgari, Ph.D.

      Affiliations

    • Physical Fitness Research Center, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • Department of Physiology and Biophysics, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • ,
  • Ali Noroozzadeh, M.Sc.

      Affiliations

    • Department of Physiology and Biophysics, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • ,
  • Khalil Poorkhalili, Ph.D.

      Affiliations

    • Department of Physiology, School of Medical Sciences, Tarbiat Modares University, Teheran, Iran
    • ,
  • Hannaneh Wahhab Aghai, Ph.D.

      Affiliations

    • Department of Physiology and Biophysics, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • ,
  • Ali Khoshbaten, Ph.D.

      Affiliations

    • Research Center for Chemical Injuries, Baqiyatallah University of Medical Sciences, Teheran, Iran
    • Department of Physiology and Biophysics, Baqiyatallah University of Medical Sciences, Teheran, Iran

Received 24 September 2007

References 

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  8. Tahepold P, Ruusalepp A, Li G, et al. Cardioprotection by breathing hyperoxic gas-relation to oxygen concentration and exposure time in rats and mice. Eur J Cardiothorac Surg. 2002;21:987
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  10. Tahepold P, Vaage J, Starkopf J, et al. Hyperoxia elicits myocardial protection through a nuclear factor κB-dependent mechanism in the rat heart. J Thorac Cardiovasc Surg. 2003;125:650
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  12. Choi H, Kim SH, Chun YS, et al. In vivo hyperoxic preconditioning prevents myocardial infarction by expressing bcl-2. Exp Biol Med (Maywood). 2006;231:463
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  14. Bigdeli MR, Hajizadeh S, Froozandeh M, et al. Prolonged and intermittent normobaric hyperoxia induce different degrees of ischemic tolerance in rat brain tissue. Brain Res. 2007;1152:228
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  17. Vanden Hoek TL, Becker LB, Shao Z, et al. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem. 1998;273:18092
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  19. Sun JZ, Tang XL, Park SW, et al. Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs. J Clin Invest. 1996;97:562
  20. Brueckl C, Kaestle S, Kerem A, et al. Hyperoxia-induced reactive oxygen species formation in pulmonary capillary endothelial cells in situ. Am J Respir Cell Mol Biol. 2006;34:453
  21. Labruto F, Yang J, Vaage J, et al. Role of tumor necrosis factor alpha and its receptor I in preconditioning by hyperoxia. Basic Res Cardiol. 2005;100:198
  22. Dong H, Xiong L, Zhu Z, et al. Preconditioning with hyperbaric oxygen and hyperoxia induces tolerance against spinal cord ischemia in rabbits. Anesthesiology. 2002;96:907
  23. Tahepold P, Elfstrom P, Eha I, et al. Exposure of rats to hyperoxia enhances relaxation of isolated aortic rings and reduces infarct size of isolated hearts. Acta Physiol Scand. 2002;175:271
  24. Ruusalepp A, Czibik G, Flatebo T, et al. Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases. Basic Res Cardiol. 2007;102:318
  25. Illes RW, Swoyer KD. Prospective, randomized clinical study of ischemic preconditioning as an adjunct to intermittent cold blood cardioplegia. Ann Thorac Surg. 1998;65:748
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PII: S0022-4804(07)02442-0

doi: 10.1016/j.jss.2007.12.802

Journal of Surgical Research
Volume 151, Issue 1 , Pages 55-61 , January 2009

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