Journal of Surgical Research
Volume 151, Issue 1 , Pages 62-67 , January 2009

Zinc Aspartate Alleviates Lung Injury Induced by Intestinal Ischemia-Reperfusion in Rats

  • Hasan Türüt, M.D.

      Affiliations

    • Department of Thoracic Surgery, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Thoracic Surgery, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    • ,
  • Ergul Belge Kurutas, M.D.

      Affiliations

    • Department of Biochemistry, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    • ,
  • Ertan Bulbuloglu, M.D.

      Affiliations

    • Department of General Surgery, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    • ,
  • Alptekin Yasım, M.D.

      Affiliations

    • Department of Cardiovascular Surgery, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    • ,
  • Mesut Özkaya, M.D.

      Affiliations

    • Department of Endocrinology, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    • ,
  • Ahmet Onder, M.D.

      Affiliations

    • Department of General Surgery, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    • ,
  • Secil Simsek Imrek, M.D.

      Affiliations

    • Department of Biochemistry, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey

Received 27 September 2007

References 

  1. Zimmerman BJ, Granger DN. Mechanisms of reperfusion injury. Am J Med Sci. 1994;307:284
  2. Atahan E, Ergun Y, Kurutas EB, et al. Ischemia-reperfusion injury in rat skeletal muscle is attenuated by zinc aspartate. J Surg Res. 2007;137:109
  3. Liu KX, Wu WK, He W, et al. Ginkgo biloba extract (EGb 761) attenuates lung injury induced by intestinal ischemia/reperfusion in rats: Roles of oxidative stress and nitric oxide. World J Gastroenterol. 2007;13:299
  4. Sorkine P, Setton A, Halpern P, et al. Soluble tumor necrosis factor receptors reduce bowel ischemia-induced lung permeability and neutrophil sequestration. Crit Care Med. 1995;23:1377
  5. Ozdemir G, Inanc F. Zinc may protect remote ocular injury caused by intestinal ischemia reperfusion in rats. Tohoku J Exp Med. 2005;206:247
  6. Calikoglu M, Tamer L, Sucu N, et al. The effects of caffeic acid phenethyl ester on tissue damage in lung after hind-limb ischemia-reperfusion. Pharmacol Res. 2003;48:397
  7. Waisman D, Brod V, Wolff R, et al. Effects of hyperoxia on local and remote microcirculatory inflammatory response after splanchnic ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2003;285:H643
  8. Ozyurt H, Sogut S, Yildirim Z, et al. Inhibitory effect of caffeic acid phenethyl ester on bleomycin-induced lung fibrosis in rats. Clin Chim Acta. 2004;339:65
  9. Barut I, Tarhan OR, Kapucuoglu N, et al. Lamotrigine reduces intestinal I/R injury in the rat. Shock. 2007;28:202
  10. De Leyn P, Lerut T, Schreininemakers H, et al. Adenine nucleotide degradation in ischemic rabbit lung tissue. Am J Physiol. 1993;264:L329
  11. Gow AJ, Duran D, Malcolm S, et al. Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation. FEBS Lett. 1996;385:63
  12. Ben-Abraham R, Guttman M, Flaishon R, et al. Mesenteric artery clamping/unclamping-induced acute lung injury is attenuated by N-methyl-D-aspartate antagonist dextromethorphan. Lung. 2006;184:309
  13. Aytekin FO, Tekin K, Kabay B, et al. Antithrombin III attenuates pulmonary tissue injury caused by mesenteric ischemia-reperfusion. Am J Surg. 2005;189:161
  14. Yoshikawa T, Naito Y, Tanigawa T, et al. Effect of zinc-carnosine chelate compound (Z-103), a novel antioxidant, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Free Radic Res Commun. 1991;14:289
  15. Tons C, Klosterhalfen B, Klein HM, et al. Induction of heat shock protein 70 (HSP70) by zinc bis (DL-hydrogen aspartate) reduces ischaemic small-bowel tissue damage in rats. Langenbecks Arch Chir. 1997;382:43
  16. Ozkan KU, Boran C, Kilinc M, et al. The effect of zinc aspartate pretreatment on ischemia-reperfusion injury and early changes of blood ad tissue antioxidant enzyme activities after unilateral testicular torsion-detorsion. J Pediatr Surg. 2004;39:91
  17. Kuzu MA, Tanik A, Kale IT, et al. Effect of ischemia/reperfusion as systemic phenomenon on anastomotic healing in the left colon. World J Surg. 2000;24:990
  18. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265
  19. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 199;95:351.
  20. Worthington CE. Worthington Enzyme Manual. Freehold, NJ: Worthington Biochemical Corporation; 1972;100–101
  21. Beutler E. Red Cell Metabolism. 2nd ed. New York: Grune and Stratton Co; 1975;261–265
  22. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem. 1990;36:1440
  23. Stirpe F, Della Corte E. The regulation of rat liver xanthine oxidase (Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O)). J Biol Chem. 1969;244:3855
  24. Powell SR. The antioxidant properties of Zinc. J Nutr. 2000;130:1447S
  25. Karck M, Tanaka S, Berenshtein E, et al. The push-and-pull mechanism to scavenge redox-active transition metals: A novel concept in myocardial protection. Thorac Cardiovasc Surg. 2001;121:1169
  26. Zalewski PD. Zinc metabolism in the airway: Basic mechanisms and drug targets. Curr Opin Pharmacol. 2006;6:237
  27. Beswick PH, Brannen PC, Hurles SS. The effects of smoking and zinc on the oxidative reactions of human neutrophils. J Clin Lab Immunol. 1986;21:71
  28. Gordienko DV, Tare M, Parveen S, et al. Voltage-activated proton current in eosinophils from human blood. J Physiol. 1996;496:299
  29. Schwarzer C, Machen TE, Illek B, et al. NADPH oxidase-dependent acid production in airway epithelial cells. J Biol Chem. 2004;279:36454
  30. Chung MJ, Hogstrand C, Lee SJ. Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes. Exp Biol Med (Maywood). 2006;231:1555
  31. Chung MJ, Walker PA, Brown RW, et al. Zinc-mediated gene expression offers protection against H2O2-induced cytotoxicity. Toxicol Appl Pharmacol. 2005;205:225
  32. Sanders SA, Eisenthal R, Harrison R. NADH oxidase activity of human xanthine oxidoreductase-generation of superoxide anion. Eur J Biochem. 1997;245:541
  33. Zhang Z, Blake DR, Stevens CR, et al. A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: The role of NADH as an electron donor. Free Radic Res. 1998;28:151

PII: S0022-4804(08)00005-X

doi: 10.1016/j.jss.2008.01.004

Journal of Surgical Research
Volume 151, Issue 1 , Pages 62-67 , January 2009

Article Tools