Journal of Surgical Research
Volume 151, Issue 1 , Pages 10-14 , January 2009

The Effect of U-74389G on Liver Recovery After Acute Liver Ischemia-Reperfusion Injury in a Swine Model

  • Alexandra K. Tsaroucha, M.D., Ph.D.

      Affiliations

    • 2nd Department of Surgery and Department of Experimental Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at 2nd Department of Surgery, Medical School, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece
    • ,
  • Apostolos Papalois, Ph.D.

      Affiliations

    • Experimental–Research Center, Elpen Pharmaceuticals, Athens, Greece
    • ,
  • Spyridon Vernadakis, M.D.

      Affiliations

    • 2nd Department of Surgery and Department of Experimental Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • ,
  • Stavros Adamopoulos, M.D.

      Affiliations

    • 2nd Department of Surgery and Department of Experimental Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • ,
  • Konstantinos Papadopoulos, M.D.

      Affiliations

    • 2nd Department of Surgery and Department of Experimental Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • ,
  • Maria Lambropoulou, M.D., Ph.D.

      Affiliations

    • Laboratory of Histology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • ,
  • Theodoros Constadinidis, M.D., Ph.D.

      Affiliations

    • Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • ,
  • Avgi Kyriazi, M.D.

      Affiliations

    • 2nd Department of Surgery and Department of Experimental Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • ,
  • Nikolaos Papadopoulos, M.D., Ph.D.

      Affiliations

    • Laboratory of Histology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    • ,
  • Constantinos Simopoulos, M.D., Ph.D.

      Affiliations

    • 2nd Department of Surgery and Department of Experimental Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

Received 11 September 2007

References 

  1. Bismuth H, Castaing D, Garden OJ. Major hepatic resection under total vascular exclusion. Ann Surg. 1989;210:13
  2. Masuko H, Jin MB, Horiuchi H, et al. Protective effect of agiotensin II type I receptor antagonist (CV-11974, on ischaemia and reperfusion injury of the liver). Transplantation. 2001;71:1034
  3. Uhlmann D, Armann B, Gaebel G, et al. Endothelin A receptor blockade reduces hepatic ischaemia/reperfusion injury after warm ischaemia in a pig model. J Gastrointest Surg. 2003;7:331
  4. Hillinger S, Schmid RA, Stammberger U, et al. Donor and recipient treatment with the Lazaroid U-74006F do not improve post-transplant lung function in swine. Eur J Cardiothorac Surg. 1999;15:475
  5. Cosenza CA, Cramer DV, Cunneen SA, et al. Protective effect of the lazaroid U74006F in cold ischaemia-reperfusion injury of the liver. Hepatology. 1994;19:418
  6. Andreadou I, Poussios D, Papalois A, et al. Effect of U-74389G (21-lazaroid) on intestinal recovery after acute mesenteric ischaemia and reperfusion in rats. In Vivo. 2003;17:463
  7. Todo S, Hamada N, Zhu Y, et al. Lazaroid U-74389G for 48-hour canine liver preservation. Transplantation. 1996;61:189
  8. Rhoden EL, Pereira-Lima L, Kalil AN, et al. Effects of ischaemia and reperfusion on oxidative stress in hepatic cirrhosis induced by carbon tetrachloride in rats. Kobe J Med Sci. 2000;46:171
  9. Leventis I, Andreadou I, Papalois A, et al. A novel antioxidant non-steroidal anti-inflammatory agent protects rat liver against ischaemia-reperfusion injury. In Vivo. 2004;18:161
  10. Tanaka H, Zhu Y, Zhang S, et al. Lazaroid U-74500A for warm ischaemia and reperfusion injury of the canine small intestine. J Am Coll Surg. 1997;184:389
  11. Zumbabo M, Dominguez-Diez A, Hernandez JR, et al. Evaluation of the potential protective effect of 21-aminosteroid U-74389G on liver injury induced and prolonged partial hepatic ischaemia reperfusion in rats. Pharmacol Toxicol. 2003;93:238
  12. Iwanami K, Takeyoshi I, Ohwada S, et al. The effect of lazaroid U-74389G on extended liver resection with ischaemia in dogs. Surgery. 1999;126:908
  13. Ishizaki N, Zhu Y, Zhang S, et al. Comparison of various lazaroids compounds for protection against ischemic liver injury. Transplantation. 1997;63:202
  14. Collard CD, Gelman S. Pathophysiology, clinical manifestations and prevention of ischaemia-reperfusion injury. Anesthesiology. 2001;94:1133
  15. Takahasi T, Takeyoshi I, Hasegwa Y, et al. Lazaroid U-74389G ameliorates ischaemia-reperfusion injury in canine hearts: A histologic study. Tranplant Proc. 1998;30:3334
  16. Altavilla D, Squadrito F, Serrano M, et al. Inhibition of tumor necrosis factor and reversal of endotoxin-induced shock by U-83836E, a second generation lazaroids in rats. Br J Pharmacol. 1998;124:1293

PII: S0022-4804(08)00048-6

doi: 10.1016/j.jss.2008.01.024

Journal of Surgical Research
Volume 151, Issue 1 , Pages 10-14 , January 2009

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