Journal of Surgical Research
Volume 153, Issue 1 , Pages 71-75 , 1 May 2009

Development of a Stable Closed Femoral Fracture Model in Mice

  • Joerg H. Holstein, M.D.

      Affiliations

    • Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D-66421 Homburg/Saar, Germany
    • These authors contributed equally to this article.
    • ,
  • Romano Matthys

      Affiliations

    • AO Development Institute, Davos, Switzerland
    • These authors contributed equally to this article.
    • ,
  • Tina Histing, M.D.

      Affiliations

    • Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
    • ,
  • Steven C. Becker

      Affiliations

    • Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
    • ,
  • Martin Fiedler

      Affiliations

    • Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
    • ,
  • Patric Garcia, M.D.

      Affiliations

    • Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
    • ,
  • Christoph Meier, M.D.

      Affiliations

    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
    • ,
  • Tim Pohlemann, M.D.

      Affiliations

    • Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
    • ,
  • Michael D. Menger, M.D.

      Affiliations

    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany

Received 27 December 2007

References 

  1. Jacenko O, Olsen BR. Transgenic mouse models in studies of skeletal disorders. J Rheumatol. 1995;43S:39
  2. Bonnarens F, Einhorn TA. Production of a standard closed fracture in laboratory animal bone. J Orthop Res. 1984;2:97
  3. Cheung K, Kalurachi K, Andrew G, et al. An external fixed femoral fracture model for mice. J Orthop Res. 2003;21:685
  4. Holstein JH, Menger MD, Culemann U, et al. Development of a locking femur nail for mice. J Biomech. 2007;40:215
  5. Augat P, Margevicius K, Simon J, et al. Local tissue properties in bone healing: Influence of size and stability of the osteotomy gap. J Orthop Res. 1998;16:475
  6. Manigrasso MB, O'Connor PJ. Characterization of a closed femur fracture model in mice. J Orthop Trauma. 2004;18:687
  7. Carter DR, Beaupre GS, Giori NJ, et al. Mechanobiology of skeletal regeneration. Clin Orthop Relat Res. 1998;355S:41
  8. Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: Standardization of nomenclature, symbols, and units (Report of the ASBMR Histomorphometry Nomenclature Committee). J Bone Miner Res. 1987;2:595
  9. Goodship AE, Kenwright J. The influence of induced micromovement upon the healing of experimental tibial fractures. J Bone Joint Surg. 1985;67B:650

PII: S0022-4804(08)00146-7

doi: 10.1016/j.jss.2008.02.042

Journal of Surgical Research
Volume 153, Issue 1 , Pages 71-75 , 1 May 2009

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