Journal of Surgical Research
Volume 153, Issue 2 , Pages 231-238 , 15 May 2009

Intermittent Adenosine at the Beginning of Reperfusion Does Not Trigger Cardioprotection

Received 22 January 2008

References 

  1. Hausenloy DJ, Tsang A, Yellon DM. The reperfusion injury salvage kinase pathway: A common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc Med. 2005;15:69
  2. Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003;285:H579;[Published erratum in Am J Physiol Heart Circ Physiol 2004;286:H477.]
  3. Gelpi RJ, Morales C, Cohen MV, et al. Xanthine oxidase contributes to preconditioning's preservation of left ventricular developed pressure in isolated rat heart: Developed pressure may not be an appropriate end-point for studies of preconditioning. Basic Res Cardiol. 2002;97:40
  4. Vasara E, Katharou I, Lazou A. Myocardial adenosine does not correlate with the protection mediated by ischaemic or pharmacological preconditioning in rat heart. Clin Exp Pharmacol Physiol. 2003;30:350
  5. Awan MM, Makaula S, Forresti S, et al. Mechanisms whereby glucose deprivation triggers metabolic preconditioning in the isolated rat heart. Mol Cell Biochem. 2000;211:111
  6. Couvreur N, Lucats L, Tissier R, et al. Differential effects of postconditioning on myocardial stunning and infarction: A study in conscious dogs and anesthetized rabbits. Am J Physiol Heart Circ Physiol. 2006;291:H1345
  7. Baines CP, Goto M, Downey JM. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium. J Mol Cell Cardiol. 1997;29:207
  8. Cohen MV, Yang XM, Liu GS, et al. Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial KATP channels. Circ Res. 2001;89:273
  9. Hausenloy DJ, Wynne AM, Yellon DM. Ischemic preconditioning targets the reperfusion phase. Basic Res Cardiol. 2007;102:445
  10. Liu Y, Yang XM, Iliodromitis EK, et al. Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator. Basic Res Cardiol. 2008;103:54
  11. Zhao ZQ, McGee S, Nakanishi K, et al. Receptor-mediated cardioprotective effects of endogenous adenosine are exerted primarily during reperfusion after coronary occlusion in the rabbit. Circulation. 1993;88:709
  12. Darling CE, Solari PB, Smith CS, et al. “Postconditioning” the human heart: Multiple balloon inflations during primary angioplasty may confer cardioprotection. Basic Res Cardiol. 2007;102:274
  13. Kerendi F, Kin H, Halkos ME, et al. Remote postconditioning (Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors). Basic Res Cardiol. 2005;100:404
  14. Kin H, Zatta AJ, Lofye MT, et al. Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine. Cardiovasc Res. 2005;67:124
  15. Mykytenko J, Kerendi F, Reeves JG, et al. Long-term inhibition of myocardial infarction by postconditioning during reperfusion. Basic Res Cardiol. 2007;102:90
  16. Penna C, Cappello S, Mancardi D, et al. Post-conditioning reduces infarct size in the isolated rat heart: Role of coronary flow and pressure and the nitric oxide/cGMP pathway. Basic Res Cardiol. 2006;101:168
  17. Penna C, Mancardi D, Rastaldo R, et al. Intermittent activation of bradykinin B(2) receptors and mitochondrial K(ATP) channels trigger cardiac postconditioning through redox signaling. Cardiovasc Res. 2007;75:168
  18. Penna C, Rastaldo R, Mancardi D, et al. Post-conditioning induced cardioprotection requires signaling through a redox-sensitive mechanism, mitochondrial ATP-sensitive K(+) channel and protein kinase C activation. Basic Res Cardiol. 2006;101:180
  19. Philipp S, Yang XM, Cui L, et al. Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovasc Res. 2006;70:308
  20. Sivaraman V, Mudalgiri NR, Di Salvo C, et al. Postconditioning protects human atrial muscle through the activation of the RISK pathway. Basic Res Cardiol. 2007;102:453
  21. Vinten-Johansen J, Zhao ZQ, Zatta AJ, et al. Postconditioning: A new link in nature's armor against myocardial ischemia-reperfusion injury. Basic Res Cardiol. 2005;100:295
  22. Yang XM, Philipp S, Downey JM, et al. Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyil cyclase activation. Basic Res Cardiol. 2005;100:57
  23. Zhao ZQ, Vinten-Johansen J. Postconditioning: Reduction of reperfusion-induced injury. Cardiovasc Res. 2006;70:200
  24. Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation. 2005;112:2143
  25. Yang XC, Liu Y, Wang LF, et al. Reduction in myocardial infarct size by postconditioning in patients after percutaneous coronary intervention. J Invasive Cardiol. 2007;19:424
  26. Heusch G, Buchert A, Feldhaus S, et al. No loss of cardioprotection by postconditioning in connexin 43-deficient mice. Basic Res Cardiol. 2006;101:354
  27. Downey JM, Cohen MV. A really radical observation -a comment on Penna et al in Basic Res Cardiol (2006) 101:180. Basic Res Cardiol. 2006;101:190
  28. Tsutsumi YM, Yokoyama T, Horikawa Y, et al. Reactive oxygen species trigger ischemic and pharmacological postconditioning: In vivo and in vitro characterization. Life Sci. 2007;81:1223
  29. Vanagt WY, Cornelussen RN, Baynham TC, et al. Pacing-induced dyssynchrony during early reperfusion reduces infarct size. J Am Coll Cardiol. 2007;49:1813
  30. Penna C, Mancardi D, Tullio F, et al. Postconditioning and intermittent bradykinin induced cardioprotection require cyclooxygenase activation and prostacyclin release during reperfusion. Basic Res Cardiol. 2008;103:368
  31. Cohen MV, Downey JM. Adenosine: Trigger and mediator of cardioprotection. Basic Res Cardiol. 2008;103:203
  32. Peart JN, Headrick JP. Adenosinergic cardioprotection: Multiple receptors, multiple pathways. Pharmacol Ther. 2007;114:208
  33. Eckle T, Krahn T, Grenz A, et al. Cardioprotection by ecto-5′-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007;115:1581
  34. Van Wylen DG. Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia. Circulation. 1994;89:2283
  35. Mortimer SL, Kodl CT, Reiling CR, et al. Preconditioning-induced attenuation of purine metabolite accumulation during ischemia: Memory and multiple cycles. Basic Res Cardiol. 2000;95:119
  36. Solenkova NV, Solodushko V, Cohen MV, et al. Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. Am J Physiol Heart Circ Physiol. 2006;290:H441
  37. Marzilli M, Orsini E, Marraccini P, et al. Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation. 2000;101:2154
  38. Claeys MJ, Bosmans J, De Ceuninck M, et al. Effect of intracoronary adenosine infusion during coronary intervention on myocardial reperfusion injury in patients with acute myocardial infarction. Am J Cardiol. 2004;94:9
  39. Forman MB, Stone GW, Jackson EK. Role of adenosine as adjunctive therapy in acute myocardial infarction. Cardiovasc Drug Rev. 2006;24:116
  40. Xu Z, Downey JM, Cohen MV. Timing and duration of administration are crucial for antiinfarct effect of AMP 579 infused at reperfusion in rabbit heart. Heart Dis. 2003;5:368
  41. Mahaffey KW, Puma JA, Barbagelata NA, et al. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction (Results of a multicenter, randomized, placebo-controlled trial: The Acute Myocardial Infarction STudy of ADenosine (AMISTAD) Trial). J Am Coll Cardiol. 1999;34:1711
  42. Ross AM, Gibbons RJ, Stone GW, et al. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol. 2005;45:1775
  43. Smolenski RT, Simmonds HA, Chambers DJ. Exogenous adenosine supplied transiently during reperfusion, ameliorates depressed endogenous adenosine production in the post-ischemic rat heart. J Mol Cell Cardiol. 1997;29:333
  44. Van Wylen DG, Schmit TJ, Lasley RD, et al. Cardiac microdialysis in isolated rat hearts: Interstitial purine metabolites during ischemia. Am J Physiol. 1992;262:H1934
  45. Chen Z, Li T, Zhang B. Morphine postconditioning protects against reperfusion injury in the isolated rat hearts. J Surg Res. 2008;145:287
  46. Xu Z, Mueller RA, Park SS, et al. Cardioprotection with adenosine A2 receptor activation at reperfusion. J Cardiovasc Pharmacol. 2005;46:794
  47. Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res. 2004;61:461
  48. Pagliaro P. Differential biological effects of products of nitric oxide (NO) synthase: It is not enough to say NO. Life Sci. 2003;73:2137

PII: S0022-4804(08)00202-3

doi: 10.1016/j.jss.2008.02.070

Journal of Surgical Research
Volume 153, Issue 2 , Pages 231-238 , 15 May 2009