Journal of Surgical Research
Volume 153, Issue 2 , Pages 217-223 , 15 May 2009

Adipose Tissue-Derived Cells Improve Cardiac Function Following Myocardial Infarction

  • Katja Schenke-Layland, Ph.D.

      Affiliations

    • Cardiovascular Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine at the University of California-Los Angeles (UCLA), Los Angeles, California
  • ,
  • Brian M. Strem, Ph.D.

      Affiliations

    • Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles (UCLA), Los Angeles, California
    • Cytori Therapeutics, Inc. San Diego, California
  • ,
  • Maria C. Jordan, M.D.

      Affiliations

    • Cardiovascular Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine at the University of California-Los Angeles (UCLA), Los Angeles, California
  • ,
  • Michael T. DeEmedio, B.S.

      Affiliations

    • Cytori Therapeutics, Inc. San Diego, California
  • ,
  • Marc H. Hedrick, M.D.

      Affiliations

    • Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles (UCLA), Los Angeles, California
    • Cytori Therapeutics, Inc. San Diego, California
  • ,
  • Kenneth P. Roos, Ph.D.

      Affiliations

    • Cardiovascular Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine at the University of California-Los Angeles (UCLA), Los Angeles, California
  • ,
  • John K. Fraser, Ph.D.

      Affiliations

    • Cytori Therapeutics, Inc. San Diego, California
  • ,
  • W. Robb MacLellan, M.D.

      Affiliations

    • Cardiovascular Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine at the University of California-Los Angeles (UCLA), Los Angeles, California
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at the Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 C. E. Young Drive, MRL 3-645, Los Angeles, California, 90095-1760

Received 10 January 2008

References 

  1. Amado LC, Saliaris AP, Schuleri KH, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA. 2005;102:11474
  2. Nagaya N, Fujii T, Iwase T, et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol. 2004;287:H2670
  3. Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone marrow cell transfer after myocardial infarction: The BOOST randomized controlled clinical trial. Lancet. 2004;364:141
  4. Pagani FD, DerSimonian H, Zawadzka A, et al. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans (Histological analysis of cell survival and differentiation). J Am Coll Cardiol. 2003;41:879
  5. Assmus B, Schachinger V, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation. 2002;106:3009
  6. Nagaya N, Kangawa K, Itoh T, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation. 2005;112:1128
  7. De Ugarte DA, Morizono K, Elbarbary A, et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 2003;174:101
  8. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279
  9. Hui JH, Li L, Teo YH, et al. Comparative study of the ability of mesenchymal stem cells derived from bone marrow, periosteum, and adipose tissue in treatment of partial growth arrest in rabbit. Tissue Eng. 2005;11:904
  10. Strem BM, Hicok KC, Zhu M, et al. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med. 2005;54:132
  11. Planat-Benard V, Menard C, Andre M, et al. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res. 2004;94:223
  12. Rangappa S, Fen C, Lee EH, et al. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann Thorac Surg. 2003;75:775
  13. Yamada Y, Wang XD, Yokoyama S, et al. Cardiac progenitor cells in brown adipose tissue repaired damaged myocardium. Biochem Biophys Res Commun. 2006;342:662
  14. Planat-Benard V, Silvestre JS, Cousin B, et al. Plasticity of human adipose lineage cells toward endothelial cells: Physiological and therapeutic perspectives. Circulation. 2004;109:656
  15. Cao Y, Sun Z, Liao L, et al. Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun. 2005;332:370
  16. Heydarkhan-Hagvall S, Schenke-Layland K, Yang YQ, et al. Human adipose stem cppells: A potential cell source for cardiovascular tissue engineering. Cells Tissue Organs. 2008;in press
  17. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109:1292
  18. Kinnaird T, Stabile E, Burnett MS, et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res. 2004;94:678
  19. Nakagami H, Maeda K, Morishita R, et al. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Arterioscler Thromb Vasc Biol. 2005;25:2542
  20. 2000 Report of the AVMA Panel on Euthanasia. J Am Vet Med Assoc. 2001;218:669
  21. Chu DK, Jordan MC, Kim JK, et al. Comparing isoflurane with tribromoethanol anesthesia for echocardiographic phenotyping of transgenic mice. J Am Assoc Lab Anim Sci. 2006;45:8
  22. Roos KP, Jordan MC, Fishbein MC, et al. Hypertrophy and heart failure in mice overexpressing the sodium-calcium exchanger. J Card Fail. 2007;13:318
  23. Kern S, Eichler H, Stoeve J, et al. Comparative analysis of mesenchymal stem cells from bone marrow (Umbilical cord blood or adipose tissue). Stem Cells. 2006;24:1294
  24. Sun S, Guo Z, Xiao X, et al. Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method. Stem Cells. 2003;21:527
  25. Kähler CM, Wechselberger J, Hilbe W, et al. Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res. 2007;9:50
  26. Zhang W, Zhang G, Jin H, et al. Characteristics of bone marrow-derived endothelial progenitor cells in aged mice. Biochem Biophys Res Commun. 2006;348:1018
  27. Krause DS, Theise ND, Collector MI, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001;10:369
  28. Valina C, Pinkernell K, Song YH, et al. Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodeling after acute myocardial infarction. Eur Heart J. 2007;28:2667
  29. Strem BM, Zhu M, Alfonso Z, et al. Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of acute myocardial injury. Cytotherapy. 2005;7:282
  30. Zhang DZ, Gai LY, Liu HW, et al. Transplantation of autologous adipose-derived stem cells ameliorates cardiac function in rabbits with myocardial infarction. Chin Med J (Engl). 2007;120:300
  31. Li B, Zeng Q, Wang H, et al. Adipose tissue stromal cells transplantation in rats of acute myocardial infarction. Coron Artery Dis. 2007;18:221
  32. Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701
  33. Limbourg FP, Ringes-Lichtenberg S, Schaefer A, et al. Hematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment. Eur J Heart Fail. 2005;7:722
  34. Anderson CD, Heydarkhan-Hagvall S, Schenke-Layland K, et al. The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury. J Surg Res. 2007;in press
  35. Uemura R, Xu M, Ahmad N, et al. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. 2006;98:1414
  36. Takahashi K, Ito Y, Morikawa M, et al. Adenoviral-delivered angiopoietin-1 reduces the infarction and attenuates the progression of cardiac dysfunction in the rat model of acute myocardial infarction. Mol Ther. 2003;8:584
  37. Li J, Brown LF, Hibberd MG, et al. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol. 1996;270:H1803
  38. Shyu KG, Wang BW, Hung HF, et al. Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction. J Biomed Sci. 2006;13:47
  39. Boquest AC, Shahdadfar A, Fronsdal K, et al. Isolation and transcription profiling of purified uncultured human stromal stem cells: Alteration of gene expression after in vitro cell culture. Mol Biol Cell. 2005;16:1131
  40. Martinez-Estrada OM, Munoz-Santos Y, Julve J, et al. Human adipose tissue as a source of Flk-1+ cells: New method of differentiation and expansion. Cardiovasc Res. 2005;65:328

1 Katja Schenke-Layland and Brian M. Strem contributed equally to this work.

PII: S0022-4804(08)00204-7

doi: 10.1016/j.jss.2008.03.019

Journal of Surgical Research
Volume 153, Issue 2 , Pages 217-223 , 15 May 2009