Journal of Surgical Research
Volume 153, Issue 1 , Pages 17-22 , 1 May 2009

Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell

  • Jianping Gong, Ph.D.

      Affiliations

    • Department of General Surgery, the 2nd College of Clinical Medicine and the 2nd Affiliated Hospital of Chongqing University of Medical Science, Chongqing, China
    • ,
  • Jinjing Wang, Ph.D.

      Affiliations

    • Laboratory of Transplant Immunology, Western China Hospital, Sichuan University, Chengdu, China
    • ,
  • Ke Ren, M.Med.

      Affiliations

    • Department of General Surgery, the 2nd College of Clinical Medicine and the 2nd Affiliated Hospital of Chongqing University of Medical Science, Chongqing, China
    • ,
  • Chang'an Liu, M.B.

      Affiliations

    • Department of General Surgery, the 2nd College of Clinical Medicine and the 2nd Affiliated Hospital of Chongqing University of Medical Science, Chongqing, China
    • ,
  • Bo Li, M.D.

      Affiliations

    • Department of General Surgery, the 2nd College of Clinical Medicine and the 2nd Affiliated Hospital of Chongqing University of Medical Science, Chongqing, China
    • ,
  • Yujun Shi, Ph.D.

      Affiliations

    • Department of General Surgery, the 2nd College of Clinical Medicine and the 2nd Affiliated Hospital of Chongqing University of Medical Science, Chongqing, China
    • Laboratory of Transplant Immunology, Western China Hospital, Sichuan University, Chengdu, China
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Laboratory of Transplant Immunology, Western China Hospital, Sichuan University, 1# Keyuan 4 Road, Chengdu, 610041, PR. China

Received 15 December 2007

References 

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  2. Fox CJ, Hammerman PS, Cinalli RM, et al. The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev. 2003;17:1841
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  5. van der Lugt NM, Domen J, Verhoeven E, et al. Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2. EMBO J. 1995;14:2536
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  9. Saris CJ, Domen J, Berns A. The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J. 1991;10:655
  10. Van Lohuizen M, Verbeek S, Krimpenfort P, et al. Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell. 1989;56:673
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  13. Xu XP, Li KZ, Dou KF, et al. Effect of coenzyme I on apoptosis of liver cell line L02 induced by ischemia-reperfusion injury. Di Yi Jun Yi Da Xue Xue Bao. 2002;22:512
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  16. Shen HL, Xu W, Wu ZY, et al. Vector-based RNAi approach to isoform-specific downregulation of vascular endothelial growth factor (VEGF)165 expression in human leukemia cells. Leukoc Res. 2007;31:515
  17. Tsutsumi H, Kumagai T, Naitoo S, et al. Synthetic peptide (P-21) derived from Asp-hemolysin inhibits the induction of apoptosis on HUVECs by lysophosphatidylcholine. Biol Pharm Bull. 2006;29:907
  18. Zhang H, Brandt R, Heim J, et al. Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation. Int J Oncol. 1999;14:113
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PII: S0022-4804(08)00237-0

doi: 10.1016/j.jss.2008.03.033

Journal of Surgical Research
Volume 153, Issue 1 , Pages 17-22 , 1 May 2009

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