Journal of Surgical Research
Volume 152, Issue 1 , Pages 84-88 , March 2009

The Oxidative Response in the Chronic Constriction Injury Model of Neuropathic Pain

  • Edward C.T.H. Tan, M.D.

      Affiliations

    • Department of General Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Radboud University Nijmegen Medical Centre, The Netherlands, 690 Department of General Surgery–Traumatology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • ,
  • Soheyl Bahrami, Ph.D.

      Affiliations

    • Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    • ,
  • Andrey V. Kozlov, Ph.D.

      Affiliations

    • Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    • ,
  • Harry A.J.M. Kurvers, M.D., Ph.D.

      Affiliations

    • Department of General Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • Henk J. Ter Laak, Ph.D.

      Affiliations

    • Departments of Pathology and Neurology, Radboud University Nijmegen Medical Centre, Nijemen, The Netherlands
    • ,
  • Hans Nohl, Ph.D.

      Affiliations

    • Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria
    • ,
  • Heinz Redl, Ph.D.

      Affiliations

    • Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    • ,
  • R. Jan. A. Goris, M.D., Ph.D.

      Affiliations

    • Department of General Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Received 30 October 2007

References 

  1. Naik AK, Tandan SK, Dudhgaonkar SP, et al. Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats. Eur J Pain. 2006;10:573
  2. Tal M. A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. Neuroreport. 1996;7:1382
  3. Khalil Z, Liu T, Helme RD. Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain. 1999;79:31
  4. Kim HK, Park SK, Zhou JL, et al. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain. 2004;111:116
  5. Kurvers HA, Tangelder GJ, De Mey JG, et al. Influence of partial nerve injury in the rat on efferent function of sympathetic and antidromically acting sensory nerve fibers. J Trauma. 1996;41:981
  6. Daemen M, Kurvers H, Bullens P, et al. Neurogenic inflammation and reflex sympathetic dystrophy (in vivo and in vitro assessment in an experimental model). Acta Orthop Belg. 1998;64:441
  7. Khalil Z, Khodr B. A role for free radicals and nitric oxide in delayed recovery in aged rats with chronic constriction nerve injury. Free Radic Biol Med. 2001;31:430
  8. van der Laan L, Kapitein PJ, Oyen WJ, et al. A novel animal model to evaluate oxygen derived free radical damage in soft tissue. Free Radic Res. 1997;26:363
  9. Kozlov AV, Szalay L, Umar F, et al. EPR analysis reveals three tissues responding to endotoxin by increased formation of reactive oxygen and nitrogen species. Free Radic Biol Med. 2003;34:1555
  10. Kozlov AV, Azizova OA, Vladimirov YuA. Radiospectroscopic analysis of serum proteins and its potential for use in medical diagnosis. 2nd ed.. UK: Harwood Academic Publishers GmbH; 1991;
  11. Hubel CA, Kozlov AV, Kagan VE, et al. Decreased transferrin and increased transferrin saturation in sera of women with preeclampsia: Implications for oxidative stress. Am J Obstet Gynecol. 1996;175:692
  12. Sadeh M, Czyewski K, Stern LZ. Chronic myopathy induced by repeated bupivacaine injections. J Neurol Sci. 1985;67:229
  13. Daemen MA, Kurvers HA, Kitslaar PJ, et al. Neurogenic inflammation in an animal model of neuropathic pain. Neurol Res. 1998;20:41

PII: S0022-4804(08)00239-4

doi: 10.1016/j.jss.2008.03.035

Journal of Surgical Research
Volume 152, Issue 1 , Pages 84-88 , March 2009

Article Tools

* Image Usage & Resolution