Journal of Surgical Research
Volume 153, Issue 2 , Pages 188-194 , 15 May 2009

Subacute Neural Stem Cell Therapy for Traumatic Brain Injury

  • Matthew T. Harting, M.D.

      Affiliations

    • University of Texas Medical School at Houston, Department of Pediatric Surgery, Houston, Texas
    • ,
  • LeeAnn E. Sloan, B.S.

      Affiliations

    • University of Texas Medical School at Houston, Department of Pediatric Surgery, Houston, Texas
    • ,
  • Fernando Jimenez, M.S.

      Affiliations

    • University of Texas Medical School at Houston, Department of Pediatric Surgery, Houston, Texas
    • ,
  • James Baumgartner, M.D.

      Affiliations

    • Children's Memorial Hermann Hospital, Houston, Texas
    • ,
  • Charles S. Cox Jr, M.D.

      Affiliations

    • University of Texas Medical School at Houston, Department of Pediatric Surgery, Houston, Texas
    • Children's Memorial Hermann Hospital, Houston, Texas
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin St., MSB 5.254, Houston, TX 77030

Received 8 January 2008

References 

  1. Kraus JF, Fife D, Conroy C. Pediatric brain injuries: The nature, clinical course, and early outcomes in a defined United States' population. Pediatrics. 1987;79:501
  2. Keel M, Trentz O. Pathophysiology of polytrauma. Injury. 2005;36:691
  3. Consensus conference. Rehabilitation of persons with traumatic brain injury (NIH Consensus Development Panel on Rehabilitation of Persons with Traumatic Brain Injury). JAMA. 1999;282:974
  4. Doppenberg EM, Choi SC, Bullock R. Clinical trials in traumatic brain injury: Lessons for the future. J Neurosurg Anesthesiol. 2004;16:87
  5. Sinson G, Voddi M, McIntosh TK. Combined fetal neural transplantation and nerve growth factor infusion: Effects on neurological outcome following fluid-percussion brain injury in the rat. J Neurosurg. 1996;84:655
  6. Riess P, Zhang C, Saatman KE, et al. Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery. 2002;51:1043;discussion 1052.
  7. Wennersten A, Meier X, Holmin S, et al. Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury. J Neurosurg. 2004;100:88
  8. Gao J, Prough DS, McAdoo DJ, et al. Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury. Exp Neurol. 2006;201:281
  9. Shindo T, Matsumoto Y, Wang Q, et al. Differences in the neuronal stem cells survival, neuronal differentiation and neurological improvement after transplantation of neural stem cells between mild and severe experimental traumatic brain injury. J Med Invest. 2006;53:42
  10. Molcanyi M, Riess P, Bentz K, et al. Trauma-associated inflammatory response impairs embryonic stem cell survival and integration after implantation into injured rat brain. J Neurotrauma. 2007;24:625
  11. Lighthall JW. Controlled cortical impact: A new experimental brain injury model. J Neurotrauma. 1988;5:1
  12. Fujimoto ST, Longhi L, Saatman KE, et al. Motor and cognitive function evaluation following experimental traumatic brain injury. Neurosci Biobehav Rev. 2004;28:365
  13. Mahmood A, Lu D, Wang L, et al. Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery. 2001;49:1196;discussion 1203.
  14. Guzowski JF, McGaugh JL. Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proc Natl Acad Sci USA. 1997;94:2693
  15. Schenk F, Morris RG. Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Exp Brain Res Exp Hirnforschung. 1985;58:11
  16. Bakshi A, Shimizu S, Keck CA, et al. Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury. Eur J Neurosci. 2006;23:2119
  17. Shear DA, Tate MC, Archer DR, et al. Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury. Brain Res. 2004;1026:11
  18. Tate MC, Shear DA, Hoffman SW, et al. Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain. Cell Transplant. 2002;11:283
  19. Zhang C, Saatman KE, Royo NC, et al. Delayed transplantation of human neurons following brain injury in rats: A long-term graft survival and behavior study. J Neurotrauma. 2005;22:1456
  20. Arvin B, Neville LF, Barone FC, et al. The role of inflammation and cytokines in brain injury. Neurosci Biobehav Rev. 1996;20:445
  21. Allan SM. The role of pro- and antiinflammatory cytokines in neurodegeneration. Ann NY Acad Sci. 2000;917:84
  22. Morganti-Kossmann MC, Rancan M, Stahel PF, et al. Inflammatory response in acute traumatic brain injury: A double-edged sword. Curr Opin Crit Care. 2002;8:101
  23. Shohami E, Ginis I, Hallenbeck JM. Dual role of tumor necrosis factor alpha in brain injury. Cytokine Growth Factor Rev. 1999;10:119
  24. Kelly S, Bliss TM, Shah AK, et al. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc Natl Acad Sci USA. 2004;101:11839
  25. Okano H. Stem cell biology of the central nervous system. J Neurosci Res. 2002;69:698
  26. Harting MT, Jimenez F, Adams SD, et al. Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy. J Surg Res. 2008;144:425

PII: S0022-4804(08)00241-2

doi: 10.1016/j.jss.2008.03.037

Journal of Surgical Research
Volume 153, Issue 2 , Pages 188-194 , 15 May 2009

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