« Previous
Next »
Journal of Surgical Research
Volume 152, Issue 1
, Pages 18-25
, March 2009
ERK/BCL-2 Pathway in the Resistance of Pancreatic Cancer to Anoikis
References
- . Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol. 1994;124:619
- . Molecular mechanisms of “detachment-induced apoptosis—Anoikis”. Apoptosis. 2002;7:247
- . Anoikis: Cancer and the homeless cell. Nature. 2004;430:973
- . Pancreatic cancer: State-of-the-art care. CA Cancer J Clin. 2000;50:241
- . Anoikis mechanisms. Curr Opin Cell Biol. 2001;13:555
- Prognostic factors in resectable pancreatic cancer: p53 and BCL-2. J Gastrointest Surg. 1999;3:263
- Expression of the bcl-2 gene and its significance in human pancreatic carcinoma. Hepatobiliary Pancreat Dis Int. 2002;1:306
- Bcl-2 expression in pancreas development and pancreatic cancer progression. J Pathol. 2001;194:444
- . Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann Surg Oncol. 1999;6:279
- . BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines. Cancer. 2001;92:1122
- MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem. 2000;79:355
- Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma. Ann Surg Oncol. 2006;13:933
- PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. J Biol Chem. 1995;270:27489
- . A study of death by anoikis in cultured epithelial cells. Cell Prolif. 2001;34:199
- Schedule-dependent molecular effects of the proteasome inhibitor Velcade and gemcitabine in pancreatic cancer. J Surg Res. 2003;113:88
- AKT inhibition is associated with chemosensitization in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer. 2003;89:391
- Activation of MAP kinases in growth responsive pancreatic cancer cell line. Cellular Signalling. 1999;11:591
- . The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions. Growth Factors. 2006;24:21
- Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res. 2004;64:4585
- Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis. Oncogene. 2004;23:9052
- Activation of ERK, controlled by Rac1 and Cdc42 via Akt, is required for anoikis. Ann NY Acad Sci. 2002;973:145
- Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004;502:169
- Targeting BCL-2 overexpression in various human malignancies through NF-B inhibition by the proteasome inhibitor bortezomib. Cancer Chemother Pharmacol. 2005;56:46
- Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells. J Surg Res. 2006;136:325
- Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma. J Clin Oncol. 2003;21:1301
- A Phase I pharmacokinetic and biological correlative study of oblimersen sodium (genasense, g3139), an antisense oligonucleotide to the bcl-2 mRNA, and of docetaxel in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2004;10:5048
- Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The Oblimersen Melanoma Study Group. J Clin Oncol. 2006;24:4738
- Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res. 2007;67:1176
PII: S0022-4804(08)00364-8
doi: 10.1016/j.jss.2008.05.017
© 2009 Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Surgical Research
Volume 152, Issue 1
, Pages 18-25
, March 2009
