Journal of Surgical Research
Volume 153, Issue 2 , Pages 210-216 , 15 May 2009

Thiazolidinediones Downregulate Wnt/β-Catenin Signaling Via Multiple Mechanisms in Breast Cancer Cells

  • Pei-Shan Wang, M.S.

      Affiliations

    • Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio
    • Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio
    • ,
  • Fu-Sheng Chou, M.D.

      Affiliations

    • Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio
    • Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio
    • ,
  • Mark Bloomston, M.D.

      Affiliations

    • Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio
    • Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio
    • ,
  • Martin S. Vonau, M.S.

      Affiliations

    • Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio
    • Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio
    • ,
  • Motoyasu Saji, M.D., Ph.D.

      Affiliations

    • Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio
    • Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio
    • ,
  • Allan Espinosa, M.D.

      Affiliations

    • Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio
    • Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio
    • ,
  • Joseph J. Pinzone, M.D.

      Affiliations

    • Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio
    • Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at The Ohio State University, 445C, McCampbell Hall, 1581 Dodd Dr., Columbus, OH 43210

Received 10 January 2008

References 

  1. Michalik L, Desvergne B, Wahli W. Peroxisome-proliferator-activated receptors and cancers: Complex stories. Nat Rev Cancer. 2004;4:61
  2. Almeida M, Han L, Bellido T, et al. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem. 2005;280:41342
  3. Betz MJ, Shapiro I, Fassnacht M, et al. Peroxisome proliferator-activated receptor-gamma agonists suppress adrenocortical tumor cell proliferation and induce differentiation. J Clin Endocrinol Metab. 2005;90:3886
  4. Boitier E, Gautier JC, Roberts R. Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: Relevance for human health and disease. Comp Hepatol. 2003;2:3
  5. Fajas L, Egler V, Reiter R, et al. PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner. Oncogene. 2003;22:4186
  6. Kikuchi A, Kishida S, Yamamoto H. Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp Mol Med. 2006;38:1
  7. Brun RP, Kim JB, Hu E, et al. Adipocyte differentiation: A transcriptional regulatory cascade. Curr Opin Cell Biol. 1996;8:826
  8. Spiegelman BM. PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor. Diabetes. 1998;47:507
  9. Lin TP, Guzman RC, Osborn RC, et al. Role of endocrine, autocrine, and paracrine interactions in the development of mammary hyperplasia in Wnt-1 transgenic mice. Cancer Res. 1992;52:4413
  10. Willert K, Shibamoto S, Nusse R. Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev. 1999;13:1768
  11. Lee FS, Lane TF, Kuo A, et al. Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. Proc Natl Acad Sci USA. 1995;92:2268
  12. Roelink H, Wagenaar E, Lopes da Silva S, et al. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc Natl Acad Sci USA. 1990;87:4519
  13. Tsukamoto AS, Grosschedl R, Guzman RC, et al. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell. 1988;55:619
  14. Milovanovic T, Planutis K, Nguyen A, et al. Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Int J Oncol. 2004;25:1337
  15. Jonsson M, Borg A, Nilbert M, et al. Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer. Eur J Cancer. 2000;36:242
  16. Imbert A, Eelkema R, Jordan S, et al. Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol. 2001;153:555
  17. Michaelson JS, Leder P. beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene. 2001;20:5093
  18. Schlosshauer PW, Brown SA, Eisinger K, et al. APC truncation and increased beta-catenin levels in a human breast cancer cell line. Carcinogenesis. 2000;21:1453
  19. Nakopoulou L, Mylona E, Papadaki I, et al. Study of phospho-beta-catenin subcellular distribution in invasive breast carcinomas in relation to their phenotype and the clinical outcome. Mod Pathol. 2006;19:556
  20. Ozaki S, Ikeda S, Ishizaki Y, et al. Alterations and correlations of the components in the Wnt signaling pathway and its target genes in breast cancer. Oncol Rep. 2005;14:1437
  21. Satoh S, Daigo Y, Furukawa Y, et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet. 2000;24:245
  22. Behrens J, Lustig B. The Wnt connection to tumorigenesis. Int J Dev Biol. 2004;48:477
  23. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999;398:422
  24. Sharma C, Pradeep A, Wong L, et al. Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. J Biol Chem. 2004;279:35583
  25. Smalley MJ, Dale TC. Wnt signaling and mammary tumorigenesis. J Mammary Gland Biol Neoplasia. 2001;6:37
  26. Howe LR, Brown AM. Wnt signaling and breast cancer. Cancer Biol Ther. 2004;3:36
  27. Benhaj K, Akcali KC, Ozturk M. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Oncol Rep. 2006;15:701
  28. Inestrosa NC, Godoy JA, Quintanilla RA, et al. Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: Role of Wnt signaling. Exp Cell Res. 2005;304:91
  29. Kawanami T, Kurita K, Yamakawa M, et al. Cerebrovascular disease in acute leukemia: A clinicopathological study of 14 patients. Intern Med. 2002;41:1130

PII: S0022-4804(08)00387-9

doi: 10.1016/j.jss.2008.05.032

Journal of Surgical Research
Volume 153, Issue 2 , Pages 210-216 , 15 May 2009

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