Journal of Surgical Research
Volume 152, Issue 2 , Pages 189-197 , April 2009

Co-Expression of Urokinase With Haptoglobin in Human Carcinomas

  • Shashikumar Harvey, Ph.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • Shin Kohga, M.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • Sheila N.J. Sait, Ph.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • Gabor Markus, Ph.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • Thelma C. Hurd, M.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Surgical Oncology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • Maisie Martinick, B.S.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Surgical Oncology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • Joseph Geradts, M.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • Rakhee Saxena, M.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • ,
  • John F. Gibbs, M.D.

      Affiliations

    • Department of Pathology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Biochemistry, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Department of Surgical Oncology, Roswell Park Cancer Institute and State University of New York at Buffalo, Buffalo, New York
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of GI Surgery and Endoscopy, Roswell Park Cancer Institute, Buffalo, NY 14263

Received 6 February 2007

References 

  1. El Ghmati SM, Van Hoeyveld EM, Van Strijp JG, et al. Identification of haptoglobin as an alternative ligand for CD11b/CD18. J Immunol. 1996;156:2542
  2. Gutteridge JM. The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. Biochim Biophys Acta. 1987;917:219
  3. Snellman O, Sylven B. Haptoglobin acting as a natural inhibitor of cathepsin B activity. Nature. 1967;216:1033
  4. Kim IK, Lee JH, Kim HS, et al. A novel function of haptoglobin: haptoglobin-haemoglobin complex induces apoptosis of hepatocarcinomatous Hep 3B cells. Scand J Clin Lab Invest. 1995;55:529
  5. Cid MC, Grant DS, Hoffman GS, et al. Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis. J Clin Invest. 1993;91:977
  6. Harvey W, Srour EF, Turner R, et al. Characterization of a new cell line (ESKOL) resembling hairy-cell leukemia: A model for oncogene regulation and late B-cell differentiation. Leuk Res. 1991;15:733
  7. Harvey SR, Nayak SK, Markus G, et al. Cancer cells release a covalent complex containing disulfide-linked domains from urinary plasminogen activator, neural cell adhesion molecule, and haptoglobin alpha and beta chains. Arch Biochem Biophys. 1997;345:289
  8. Harvey SR, Sait SN, Xu Y, et al. Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization. Am J Pathol. 1999;155:1115
  9. Hurd TC, Sait S, Kohga S, et al. Plasminogen activator system localization in 60 cases of ductal carcinoma in situ. Ann Surg Oncol. 2007;14:3117
  10. Grondahl-Hansen J, Ralfkiaer E, Kirkeby L, et al. Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans. Am J Pathol. 1991;138:111
  11. Pyke C, Kristensen P, Ralfkiaer E, et al. Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. Am J Pathol. 1991;138:1059
  12. Hewitt R, Dano K. Stromal cell expression of components of matrix-degrading protease systems in human cancer. Enzyme Protein. 1996;49:163
  13. Kohga S, Harvey SR, Weaver RM, et al. Localization of plasminogen activators in human colon cancer by immunoperoxidase staining. Cancer Res. 1985;45:1787
  14. Kohga S, Harvey S, Suzumiya J, Sumiyoshi A, Markus G. Comparison of the immunohistochemical localization of urokinase in normal and cancer human colon tissue. Fibrinolysis. 1989;3:17–22
  15. Oh SK, Very DL, Walker J, et al. An analogy between fetal haptoglobin and a potent immunosuppressant in cancer. Cancer Res. 1987;47:5120
  16. Elg SA, Carson LF, Fowler JM, et al. Ascites levels of haptoglobin in patients with ovarian cancer. Cancer. 1993;71:3938
  17. Kuhajda FP, Piantadosi S, Pasternack GR. Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease. New Engl J Med. 1989;321:636
  18. Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem. 1996;42:1589
  19. Kuhajda FP, Katumuluwa AI, Pasternack GR. Expression of haptoglobin-related protein and its potential role as a tumor antigen. Proc Natl Acad Sci USA. 1989;86:1188
  20. Schmitt M, Wilhelm O, Reuning U, et al. The urokinase plasminogen activator system as a novel target for tumour therapy. Fibrinolysis Proteolysis. 2000;14:14
  21. Nielsen B, Sehested M, Timshel S, et al. Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer. Lab Invest. 1996;74:168
  22. Harvey SR, Lawrence DD, Madeja JM, et al. Secretion of plasminogen activators by human colorectal and gastric tumor explants. Clin Exp Metastasis. 1988;6:431

PII: S0022-4804(08)00408-3

doi: 10.1016/j.jss.2008.06.016

Journal of Surgical Research
Volume 152, Issue 2 , Pages 189-197 , April 2009

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