Journal of Surgical Research
Volume 155, Issue 2 , Pages 210-216 , August 2009

Erdosteine and Ebselen As Useful Agents in Intestinal Ischemia/Reperfusion Injury

  • Turan Tunc, M.D.

      Affiliations

    • Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Bulent Uysal, M.D.

      Affiliations

    • Department of Physiology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Cuneyt Atabek, M.D.

      Affiliations

    • Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Vural Kesik, M.D.

      Affiliations

    • Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Bahadir Caliskan, M.D.

      Affiliations

    • Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Emin Oztas, M.D.

      Affiliations

    • Department of Medical Histology and Embryology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Nail Ersoz, M.D.

      Affiliations

    • Department of General Surgery, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Sukru Oter, M.D.

      Affiliations

    • Department of Physiology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • ,
  • Ahmet Guven, M.D.

      Affiliations

    • Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Pediatric Surgery, Gulhane Military Medical Faculty, Etlik/Ankara, Turkey 06018

Received 27 December 2007

References 

  1. Cerqueira NF, Hussni CA, Yoshida WB. Pathophysiology of mesenteric ischemia/reperfusion: A review. Acta Cir Bras. 2005;20:336
  2. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol. 2002;282:C227
  3. Schoenberg MH, Beger HG. Reperfusion injury after intestinal ischemia. Crit Care Med. 1993;21:1376
  4. Sirmali M, Uz E, Sirmali R, et al. The effects of erdosteine on lung injury induced by the ischemia-reperfusion of the hind-limbs in rats. J Surg Res. 2008;145:303
  5. Mallick IH, Yang W, Winslet MC, et al. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci. 2004;49:1359
  6. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol. 1996;271:C1424
  7. Erdogan H, Fadillioglu E, Yagmurca M, et al. Protein oxidation and lipid peroxidation after renal ischemia-reperfusion injury: Protective effects of erdosteine and N-acetylcysteine. Urol Res. 2006;34:41
  8. Deitch EA. Multiple organ failure (Pathophysiology and potential future therapy). Ann Surg. 1992;216:117
  9. Schmidt HH, Walter U. NO at work. Cell. 1994;78:919
  10. Szabo C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol Lett. 2003;140-141:105
  11. Squadrito GL, Pryor WA. Oxidative chemistry of nitric oxide: The roles of superoxide, peroxynitrite, and carbon dioxide. Free Radic Biol Med. 1998;25:392
  12. Braga PC, Dal Sasso M, Zuccotti T. Assessment of the antioxidant activity of the SH metabolite I of erdosteine on human neutrophil oxidative bursts. Arzneimittelforschung. 2000;50:739
  13. Inglesi M, Nicola M, Fregnan GB, et al. Synthesis and free radical scavenging properties of the enantiomers of erdosteine. Farmaco. 1994;40:703
  14. Muller A, Gabriel H, Sies H, et al. A novel biologically active selenooorganic compound (VII. Biotransformation of ebselen in perfused rat liver). Biochem. Pharmacol. 1988;37:1103
  15. Zhao R, Masayasu H, Holmgren A. Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Proc Natl Acad Sci U S A. 2002;99:8579
  16. Koc A, Narci A, Duru M, et al. The protective role of erdosteine on testicular tissue after testicular torsion and detorsion. Mol Cell Biochem. 2005;280:193
  17. Ozaki M, Nakamura M, Teraoka S, et al. Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. Transpl Int. 1997;10:96
  18. Imai H, Masayasu H, Dewar D, et al. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke. 2001;32:2149
  19. Moretti M, Marchioni CF. An overview of erdosteine antioxidant activity in experimental research. Pharmacol Res. 2007;55:249
  20. Korkmaz A, Oter S, Sadir S, et al. Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats. J Urol. 2005;173:1793
  21. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265
  22. Levine RL, Garland D, Oliver CN, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990;186:464
  23. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351
  24. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497
  25. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158
  26. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide. 2001;5:62
  27. Chiu CJ, McArdle AH, Brown R, et al. Intestinal mucosal lesion in low-flow states (I. A morphological, hemodynamic, and metabolic reappraisal). Arch Surg. 1970;101:478
  28. Guven A, Tunc T, Topal T, et al. α-lipoic acid and ebselen prevents ischemia/reperfusion injury in the rat intestine. Surg Today. 2008;38:1029
  29. Dechant KL, Noble S. Erdosteine. Drugs. 1996;52:875;discussion 882.
  30. Ege E, Ilhan A, Gurel A, et al. Erdosteine ameliorates neurological outcome and oxidative stress due to ischemia/reperfusion injury in rabbit spinal cord. Eur J Vasc Endovasc Surg. 2004;28:379
  31. Klotz LO, Sies H. Defenses against peroxynitrite: Selenocompounds and flavonoids. Toxicol Lett. 2003;140-141:125
  32. Yamaguchi T, Sano K, Takakura K, et al. Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial (Ebselen Study Group). Stroke. 1998;29:12
  33. Saad SY, Najjar TA, Arafah MM. Cardioprotective effects of subcutaneous ebselen against daunorubicin-induced cardiomyopathy in rats. Basic Clin Pharmacol Toxicol. 2006;99:412
  34. Salvemini D, Riley DP, Lennon PJ, et al. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. Br J Pharmacol. 1999;127:685
  35. Cuzzocrea S, Mazzon E, Costantino G, et al. Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury. Cardiovasc Res. 2000;47:537
  36. Kawasaki T, Ogata M, Kawasaki C, et al. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg. 1999;89:665
  37. Yu M, Shao D, Yang R, et al. Effects of ketamine on pulmonary inflammatory responses and survival in rats exposed to polymicrobial sepsis. J Pharm Pharm Sci. 2007;10:434
  38. Bohlen HG. Intestinal tissue PO2 and microvascular responses during glucose exposure. Am J Physiol. 1980;238:H164

PII: S0022-4804(08)00409-5

doi: 10.1016/j.jss.2008.06.017

Journal of Surgical Research
Volume 155, Issue 2 , Pages 210-216 , August 2009

Article Tools

* Image Usage & Resolution