Journal of Surgical Research
Volume 155, Issue 2 , Pages 231-236 , August 2009

A CXCR4 Antagonist CTCE-9908 Inhibits Primary Tumor Growth and Metastasis of Breast Cancer1

  • Eugene H. Huang, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • ,
  • Balraj Singh, Ph.D.

      Affiliations

    • Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • Advanced Research Center for Micrometastatic Disease, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • ,
  • Massimo Cristofanilli, M.D.

      Affiliations

    • Department of Breast Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • Advanced Research Center for Micrometastatic Disease, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • ,
  • Juri Gelovani, M.D., Ph.D.

      Affiliations

    • Department of Experimental Diagnostic Imaging, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • ,
  • Caimiao Wei, Ph.D.

      Affiliations

    • Department of Quantitative Sciences, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • ,
  • Laura Vincent, B.S.

      Affiliations

    • Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • ,
  • Kendra R. Cook, B.S.

      Affiliations

    • Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • ,
  • Anthony Lucci, M.D.

      Affiliations

    • Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • Advanced Research Center for Micrometastatic Disease, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at the Department of Surgical Oncology, Unit 444, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.

Received 9 January 2008

References 

  1. Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50
  2. Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 2003;3:537
  3. Fernandis AZ, Prasad A, Band H, et al. Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene. 2004;23:157
  4. Schmid BC, Rudas M, Resniczek GA, et al. CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasia. Breast Cancer Res Treat. 2004;84:247
  5. Allinen M, Beroukhim R, Cai L, et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004;6:17
  6. Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005;121:335
  7. Singh B, Berry JA, Shoher A, et al. COX-2 involvement in breast cancer metastasis to bone. Oncogene. 2007;26:3789
  8. Singh B, Berry JA, Vincent LE, et al. Involvement of IL-8 in COX-2 mediated bone metastases from breast cancer. J Surg Res. 2006;134:44
  9. Jenkins DE, Hornig YS, Oei Y, et al. Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice. Breast Cancer Res. 2005;7:444
  10. Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature. 2005;436:518
  11. Wetterwald A, van der Pluijm G, Que I, et al. Optical imaging of cancer metastasis to bone marrow: A mouse model of minimal residual disease. Am J Pathol. 2002;160:1143
  12. Murphy PM. Chemokines and the molecular basis of cancer metastasis. N Engl J Med. 2001;345:833
  13. Luker KE, Luker GD. Functions of CXCL12 and CXCR4 in breast cancer. Cancer Letters. 2006;238:30
  14. Smith MCP, Luker KE, Garbow JR, et al. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res. 2004;64:8604
  15. Lapteva N, Yang A, Sanders DE, et al. CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo. Cancer Gene Therapy. 2005;12:84
  16. Cristofanilli M, Buzdar AU, Hortobagyi GN. Update on the management of inflammatory breast cancer. Oncologist. 2003;8:141
  17. Cabioglu N, Gong Y, Islam R, et al. Expression of growth factor and chemokine receptors: New insights in the biology of inflammatory breast cancer. Ann Oncol. 2007;18:1021
  18. Cristofanilli M, Budd T, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 2004;351:781
  19. Cabioglu N, Sahin A, Doucet M, et al. Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrow. Clin Exp Metastasis. 2005;22:39
  20. Trent JO, Wang ZX, Murray JL, et al. Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem. 2003;278:47136
  21. Tamamura H, Hori A, Kanzaki N, et al. T140 analogs as CXCR4 antagonists identified as antimetastatic agents in the treatment of breast cancer. FEBS Lett. 2003;550:79
  22. Liang Z, Wu T, Lou H, et al. Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4. Cancer Res. 2004;64:4302
  23. Zhang WB, Navenot JM, Haribabu B, et al. A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists. J Biol Chem. 2002;277:24515

PII: S0022-4804(08)00451-4

doi: 10.1016/j.jss.2008.06.044

Journal of Surgical Research
Volume 155, Issue 2 , Pages 231-236 , August 2009

Article Tools

* Image Usage & Resolution