Journal of Surgical Research
Volume 155, Issue 1 , Pages 54-64 , July 2009

Effect of Dakin's Solution on Components of a Dermal Equivalent

  • Laura R. Vick, M.D.

      Affiliations

    • School of Medicine, Department of Surgery, University of Mississippi Medical Center, Jackson, Mississippi
    • ,
  • Ryan-Claire Propst, B.S.

      Affiliations

    • School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi
    • ,
  • Roshada Bozeman

      Affiliations

    • Tougaloo College, Tougaloo, Mississippi
    • ,
  • Annette B. Wysocki, Ph.D.

      Affiliations

    • School of Medicine, Department of Surgery, University of Mississippi Medical Center, Jackson, Mississippi
    • School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at the University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505.

Received 17 March 2008

References 

  1. Edwin Smith papyrus. Available at: http://nefertiti.iwebland.com/timelines/topics/smithpapyrus.htm. Accessed July 7, 2008.
  2. Lineaweaver W, Howard R, Soucy D, et al. Topical antimicrobial toxicity. Arch Surg. 1985;120:267
  3. Kozol RA, Gillies C, Elgebaly SA. Effects of sodium hypochlorite (Dakin's solution) on cells of the wound module. Arch Surg. 1988;123:420
  4. Heggers JP, Sazy JA, Stenberg BD, et al. Bactericidal and wound-healing properties of sodium hypochlorite solutions. J Burn Care Rehabil. 1991;12:420
  5. Heussen C, Dowdle EB. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem. 1980;102:196
  6. McKenna PJ, Lehr GS, Leist P, et al. Antiseptic effectiveness with fibroblast preservation. Ann Plast Surg. 1991;27:265
  7. Hidalgo E, Dominguez C. Growth-altering effects of sodium hypochlorite in cultured human dermal fibroblasts. Life Sci. 2000;67:1331
  8. Hidalgo E, Bartolome R, Dominguez C. Cytotoxicity mechanisms of sodium hypochlorite in cultured human dermal fibroblasts and its bactericidal effectiveness. Chem Biol Interact. 2002;139:265
  9. Fader RC, Maurer A, Stein MD, et al. Sodium hypochlorite decontamination of split-thickness cadaveric skin infected with bacteria and yeast with subsequent isolation and growth of basal cells to confluence in tissue culture. Antimicrob Agents Chemother. 1983;24:181
  10. Dakin HD. On the use of certain antiseptic substances in the treatment of infected wounds. BMJ. 1915;2:318
  11. Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol. 2003;13:264
  12. Ehrlich H. The fibroblast-populated collagen lattice. A model of fibroblast collagen interactions in repair. Methods Mol Med. 2003;78:277
  13. Brennan SS, Leaper DJ. The effect of antiseptics on the healing wound: A study using the rabbit ear chamber. Br J Surg. 1985;72:780
  14. Brennan SS, Foster ME, Leaper DJ. Antiseptic toxicity in wounds healing by secondary intention. J Hosp Infect. 1986;8:263
  15. Taylor HD, Austin JH. The solvent action of antiseptics on necrotic tissue. J Exp Med. 1918;27:155

PII: S0022-4804(08)00534-9

doi: 10.1016/j.jss.2008.08.007

Journal of Surgical Research
Volume 155, Issue 1 , Pages 54-64 , July 2009

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