Journal of Surgical Research
Volume 157, Issue 1 , Pages e7-e13 , November 2009

Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats1

  • Senol Gulmen, M.D.

      Affiliations

    • Department of Cardiovascular Surgery, Suleyman Demirel University Medical School, Isparta, Turkey
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Cardiovascular Surgery, Suleyman Demirel University Medical School, Bahcelievler Mh Istanbul Cd Daloglu Apt No:59/1 Kat:4 Daire:14, 32200, Isparta, Turkey.
    • ,
  • Ilker Kiris, M.D.

      Affiliations

    • Department of Cardiovascular Surgery, Suleyman Demirel University Medical School, Isparta, Turkey
    • ,
  • Cuneyt Narin, M.D.

      Affiliations

    • Department of Cardiovascular Surgery, Selcuk University Meram Medical School, Konya, Turkey
    • ,
  • Berit Gokce Ceylan, M.D.

      Affiliations

    • Department of Anesthesiology and Reanimation, Suleyman Demirel University Medical School, Isparta, Turkey
    • ,
  • Betul Mermi, M.D.

      Affiliations

    • Department of Biochemistry, Suleyman Demirel University Medical School, Isparta, Turkey
    • ,
  • Recep Sutcu, M.D.

      Affiliations

    • Department of Biochemistry, Suleyman Demirel University Medical School, Isparta, Turkey
    • ,
  • Ibrahim Meteoglu, M.D.

      Affiliations

    • Department of Pathology, Adnan Menderes University Medical School, Aydın, Turkey

Received 2 June 2008

References 

  1. Ozcan AV, Sacar M, Aybek H, et al. The effects of iloprost and vitamin C on kidney as a remote organ after ischemia-reperfusion of lower extremities. J Surg Res. 2007;140:20
  2. Okutan H, Savas C, Delibas N. The antioxidant effect of melatonin in lung injury after aortic occlusion-reperfusion. Interact Cardiovasc Thorac Surg. 2004;3:519
  3. Ellenberger C, Schweizer A, Diaper J, et al. Incidence, risk factors, and prognosis of changes in serum creatinine early after aortic abdominal surgery. Intensive Care Med. 2006;32:1808
  4. Williams P, Lopez H, Britt D, et al. Characterization of renal ischemia-reperfusion injury in rats. J Pharmacol Toxicol Method. 1997;37:1
  5. Singh D, Chander V, Chopra K. Protective effect of catechin on ischemia-reperfusion-induced renal injury in rats. Pharmocal Rep. 2005;57:70
  6. Kacmaz A, Polat A, User Y. Octreotide improves reperfusion-induced oxidative injury in acute abdominal hypertension in rats. J Gastrointest Surg. 2004;8:113
  7. Closel M, Ramuz H, Closel JP, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther. 1999;290:840
  8. Huang C, Huang C, Hestin D, et al. The effect of endothelin antagonists on renal ischemia- reperfusion injury and the development of acute renal failure in rat. Nephrol Dial Transplant. 2002;17:1578
  9. Baker RC, Armstrong MA, Young SI, et al. Methylprednisolone increases urinary nitrate concentrates and reduces subclinical renal injury during infrarenal aortic ischemia reperfusion. Ann Surg. 2006;244:821
  10. Shibouta Y, Suziki N, Shino A, et al. Pathophysiological role of endothelin in acute renal failure. Life Sci. 1990;46:1611
  11. Kusumoto K, Kubo K, Kandori H, et al. Effects of a new endothelin antagonist, TAK-044, on postischemic acute renal failure in rats. Life Sci. 1994;55:301
  12. Kon V, Yoshioka T, Foga A, et al. Glomeruler actions of endothelin in vivo. J Clin Invest. 1989;83:1762
  13. Jaffe M. Uber den niederschlag, welchen pikrinsaure in normalen hrn erzeugt und uber eine neue reaction des kreatinins. Z Physiol Chem. 1886;10:391
  14. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265
  15. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzimol. 1990;186:421
  16. Spits DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem. 1989;179:8
  17. Woolliams JA, Wiener G, Andersen PH, et al. Variation in the activities of glutathione peroxidase and superoxide dismutase and in the concentration of copper in the blood in various breed crosses of sheep. Res Vet Sci. 1983;34:253
  18. Aebi Y. Catalase in vitro. Methods Enzymol. 1984;105:12
  19. Tullis MJ, Brown S, Gwertz BL. Hepatic influence on pulmonary neutrophil sequastration following intestinal ischemia-reperfusion. J Surg Res. 1996;66:143
  20. Rodríguez-López JM, Sánchez-Conde P, Lozano FS, et al. Laboratory investigation: Effects of profol on the systemic inflammatory response during aortic surgery. Can J Anesth. 2006;53:643
  21. Gulec B, Coskun K, Oner K, et al. Effects of perfusion on kidney ischemia-reperfusion injury in pigs. Transplant Proc. 2006;38:371
  22. Ilhan A, Yilmaz HR, Armutcu F, et al. The protective effect of nebivolol on ischemia/reperfusion injury in rabbit spinal cord. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:1153
  23. Siems WG, Grune T, Esterbauer H. 4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine. Life Sci. 1995;57:785
  24. Singh D, Chander V, Chopra K. The effect of quercetin, a bioflavonoid on ischemia/reperfusion induced renal injury in rats. Arch Med Res. 2004;35:484
  25. Ha-Bo HE, De-Zai DAI, Yin DAI. CPU0213, a novel endothelin receptor antagonist, ameliorates septic renal lesion by suppressing ET system and NF-kB in rats. Acta Pharmocol Sin. 2006;27:1213
  26. Myers SI, Wang L, Liu F, et al. Oxygen-radical regulation of renal blood flow following suprarenal aortic clamping. J Vasc Surg. 2006;43:577
  27. Paller M, Hoidal J, Ferris T. Oxygen free radicals in ischemic acute renal failure in rat. J Clin Invest. 1984;74:1156
  28. Kiris İ, Kapan S, Kilbas A, et al. The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. J Surg Res. 2008;149:206
  29. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci. 1990;87:1620
  30. Yın M, Wheeler MD, Connor HD, et al. Cu/ Zn – superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney. J Am Soc Nephrol. 2001;12:2691
  31. Maxwell SRJ, Lip GYH. Reperfusion injury: A review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol. 1997;58:95
  32. Gurel A, Armutcu F, Sahin S, et al. Protective role of α- tocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injury via nitric oxide and myeloperoxidase in rat kidneys. Clinica Chimica Acta. 2004;339:33
  33. Schoenberg MH, Beger HG. Reperfusion injury after intestinal ischemia. Crit Med Care. 1993;21:1376
  34. Mun KC, Lee HG, Lee TH, et al. Effect of modified polyhemoglobin on the ischemia/reperfusion injury in kidney. Transplant Proc. 2003;35:99
  35. Kiris İ, Okutan H, Savas C, et al. Deneysel aortic iskemi-reperfüzyon modelinde renal hasara gadolinium klorürün etkisi. Turkish J Vasc Surg. 2005;14:13
  36. Chatterjee PK, Todorovic Z, Sivajarah A, et al. Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury. Biochem Pharmacol. 2005;69:1121
  37. Okutan H, Savas C, Ozguner IF, et al. Lung injury after aortic occlusion-reperfusion in rats. The role of gadolinium chloride. Tohoku J Exp Med. 2004;203:267
  38. Erdogan H, Fadillioglu E, Emre MH, et al. Protection from renal ischemia reperfusion injury by an endothelin-A receptor antagonist BQ-123 in relation to nitric oxide production. Toxicology. 2006;228:219
  39. Wilhelm SM, Stowe NT, Robinson AV, et al. The use of the endothelin receptor antagonist, tezosentan, before or after renal ischemia protects renal function. Transplantation. 2001;71:211
  40. Kon V, Yoshioka T, Fogo A, et al. Glomerular actions of endothelin in vivo. J Clin Invest. 1989;83:1762
  41. Shibouta Y, Suzuki N, Shino A, et al. Pathophysiological role of endothelin in acute renal failure. Life Sci. 1990;46:1611
  42. Uhlmann D, Lauer H, Serr F, et al. Pathophysiological role of platelets in acute experimental pancreatitis: Influence of endothelin A receptor blockade. Cell Tissue Res. 2007;327:485
  43. Zaid A, Abassi ZA, Ellahham S, et al. The intrarenal endothelin system and hypertension. New Physiol Sci. 2001;16:152
  44. Dingemanse J, Clozel M, Van Giersbergen PLM. Entry-into-humans study with tezosentan, an intravenous dual endothelin receptor antagonist. J Cardiovasc Pharmacol. 2002;39:795
  45. Cody RJ, Haas GJ, Bingley PF, et al. Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation. 1992;85:504
  46. Chin A, Radhakrishnan J, Fornell L, et al. Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shock. J Pediatr Surg. 2002;37:482
  47. Sivarajah A, Chatterjee PK, Patel NS, et al. Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury. Am J Nephrol. 2003;23:267
  48. Spandou E, Tsouchnikas I, Karkavelas G, et al. Erythropoietin attenuates renal injury in experimental acute renal failure ischemic/reperfusion model. Nephrol Dial Transplant. 2006;21:330

PII: S0022-4804(08)00538-6

doi: 10.1016/j.jss.2008.08.011

Journal of Surgical Research
Volume 157, Issue 1 , Pages e7-e13 , November 2009

Article Tools

* Image Usage & Resolution