Journal of Surgical Research
Volume 155, Issue 2 , Pages 195-200 , August 2009

Inhibitory Effect of Curcumin on Early Liver Regeneration Following Partial Hepatectomy in Rats

  • Daniel Seehofer, M.D.

      Affiliations

    • Department of General, Visceral, and Transplant Surgery, Charité Campus Virchow, Berlin, Germany
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of General, Visceral, and Transplant Surgery, Charité Campus Virchow, Augustenburger Platz 1, D-13353 Berlin, Germany.
    • ,
  • Anja Schirmeier

      Affiliations

    • Department of General, Visceral, and Transplant Surgery, Charité Campus Virchow, Berlin, Germany
    • ,
  • Stig Bengmark, M.D.

      Affiliations

    • Department of Hepatology and Surgery, University College of London, Liver Institute, London, United Kingdom
    • ,
  • Jessica Carter

      Affiliations

    • Department of General, Visceral, and Transplant Surgery, Charité Campus Virchow, Berlin, Germany
    • ,
  • Martin Koch, M.D.

      Affiliations

    • Department of Pathology, Charité Campus Mitte, Berlin, Germany
    • ,
  • Matthias Glanemann, M.D.

      Affiliations

    • Department of General, Visceral, and Transplant Surgery, Charité Campus Virchow, Berlin, Germany
    • ,
  • Andreas K. Nüssler, Ph.D.

      Affiliations

    • Department of Trauma Surgery, Klinikum Rechts der Isar, Technical University, Munich, Germany
    • ,
  • Peter Neuhaus, M.D.

      Affiliations

    • Department of General, Visceral, and Transplant Surgery, Charité Campus Virchow, Berlin, Germany
    • ,
  • Michael D. Menger, M.D.

      Affiliations

    • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Germany

Received 16 October 2007

References 

  1. Bengmark S. Curcumin, an atoxic antioxidant and natural NF-kappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: A shield against acute and chronic diseases. JPEN J Parenter Enteral Nutr. 2006;30:45
  2. Khopde SM, Priyadarsini KI, Venkatesan P, et al. Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue. Biophys Chem. 1999;80:85
  3. Wei QY, Chen WF, Zhou B, et al. Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochim Biophys Acta. 2006;1760:70
  4. Reddy AC, Lokesh BR. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol Cell Biochem. 1994;137:1
  5. Ghoneim AI, Abdel-Naim AB, Khalifa AE, et al. Protective effects of curcumin against ischemia/reperfusion insult in rat forebrain. Pharmacol Res. 2002;46:273
  6. Strasser EM, Wessner B, Manhart N, et al. The relationship between the anti-inflammatory effects of curcumin and cellular glutathione content in myelomonocytic cells. Biochem Pharmacol. 2005;70:552
  7. Dickinson DA, Iles KE, Zhang H, et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASB J. 2003;17:473
  8. Reddy AC, Lokesh BR. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem. 1992;111:117
  9. Khar A, Ali AM, Pardhasaradhi BVV, et al. Induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: Role of reactive oxygen intermediates. Cell Stress Chaperones. 2001;6:368
  10. McNally SJ, Harrison EM, Ross JA, et al. Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury. Transplantation. 2006;81:623
  11. Park C, Kim GY, Kim GD, et al. Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. Oncol Rep. 2006;15:1225
  12. Zheng M, Ekmekcioglu S, Walch ET, et al. Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells. Melanoma Res. 2004;14:165
  13. Seehofer D, Stockmann M, Schirmeier A, et al. Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy. Langenbeck's Arch Surg. 2007;392:273
  14. Holy JM. Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells. Mutat Res. 2002;518:71
  15. Kang J, Zheng R. Dose dependent regulation of superoxide anion on the proliferation, differentiation, apoptosis and necrosis of human hepatoma cells: The role of intracellular Ca2+. Redox Rep. 2004;9:37
  16. Wolfson N, Wilbur KM, Bernheim F. Lipid peroxide formation in regenerating liver. Exp Cell Res. 1956;10:556
  17. Aguilar-Delfin I, Lopez-Barrera F, Hernandez-Munoz R. Selective enhancement of lipid peroxidation in plasma membrane in two experimental models of liver regeneration: Partial hepatectomy and acute CCl4 administration. Hepatology. 1996;24:657
  18. Trejo-Solis C, Chagoya de Sanchez V, Aranda-Fraustro A, et al. Inhibitory effect of vitamin E administration on the progression of liver regeneration induced by partial hepatectomy in rats. Lab Invest. 2003;83:1669
  19. Nagy P, Teramoto T, Factor VM, et al. Reconstitution of liver mass via cellular hypertrophy in the rat. Hepatology. 2001;33:339
  20. Seehofer D, Neumann UP, Schirmeier A, et al. Synergistic effect of erythropoietin but not G-CSF in combination with curcumin on impaired liver regeneration in rats. Langenbecks Arch Surg. 2008;393:325
  21. Deters M, Siegers C, Muhl P, et al. Choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat. Planta Med. 1999;65:610

PII: S0022-4804(08)00591-X

doi: 10.1016/j.jss.2008.09.011

Journal of Surgical Research
Volume 155, Issue 2 , Pages 195-200 , August 2009

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