Journal of Surgical Research
Volume 157, Issue 1 , Pages 4-13 , November 2009

ATIII Attenuates Endotoxemia Induced Healing Impairment in the Colon

  • Ricarda Diller, M.D.

      Affiliations

    • Surgical Research, Department of General Surgery, University Hospital of Münster, Germany
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Surgical Research, Department of General Surgery, University Hospital of Münster, Waldeyerstraße 1, D-48149 Münster, Germany.
  • ,
  • Udo Stratmann, M.D.

      Affiliations

    • Institute of Anatomy, University Hospital of Münster, Germany
  • ,
  • Evgeni Minin, M.D.

      Affiliations

    • Gerhard Domagk Institute of Pathology, University Hospital of Münster, Germany
  • ,
  • Christoph von Eiff, M.D.

      Affiliations

    • Institute of Medical Microbiology, University Hospital of Münster, Germany
  • ,
  • Gerrit Bäumer, M.D.

      Affiliations

    • Surgical Research, Department of General Surgery, University Hospital of Münster, Germany
  • ,
  • Hannelore Huismans, M.D.

      Affiliations

    • Surgical Research, Department of General Surgery, University Hospital of Münster, Germany
  • ,
  • Tilo Helmschmied, M.D.

      Affiliations

    • Surgical Research, Department of General Surgery, University Hospital of Münster, Germany
  • ,
  • Karsten Becker, M.D.

      Affiliations

    • Institute of Medical Microbiology, University Hospital of Münster, Germany
  • ,
  • Hans-Ullrich Spiegel, M.D.

      Affiliations

    • Surgical Research, Department of General Surgery, University Hospital of Münster, Germany

Received 7 January 2008 ,Accepted 7 October 2008.

References 

  1. Ahrendt GM, Tantry US, Barbul A. Intra-abdominal sepsis impairs colonic reparative collagen synthesis. Am J Surg. 1996;171:102
  2. Ishimura K, Tsubouchi T, Okano K, et al. Wound healing of intestinal anastomosis after digestive surgery under septic conditions: Participation of local interleukin-6 expression. World J Surg. 1998;22:1069
  3. Diller R, Stratmann U, Helmschmied T, et al. Microcirculatory dysfunction in endotoxemic bowel anastomosis. J Surg Res 2008 (in press).
  4. Schilling MK, Maurer CA, Kollmar O, et al. Primary versus secondary anastomosis after sigmoid colon resection for perforated diverticulitis (Hinchey stages III and IV): A prospective outcome and cost analysis. Dis Colon Rectum. 2001;44:699
  5. Aydin HN, Remzi FH, Tekkis PP, et al. Hartman's reversal is associated with high postoperative adverse events. Dis Colon Rectum. 2005;48:2117
  6. Oomen JLT, Engel AF, Cuesta MA. Mortality after acute surgery for complications of diverticular disease of the sigmoid colon is almost exclusively due to patient related factors. Colorectal Dis. 2005;8:112
  7. Wahl W, Wern T, Kirsch D, et al. Status of discontinuity resection in septic diverticular complications. History or a still current procedure?. Zentralbl Chir. 2001;126:357
  8. Dickneite G. Antithrombin III in animal models of sepsis and organ failure. Semin Thromb Hemost. 1998;24:61
  9. Hoffmann JN, Vollmar B, Römisch J, et al. Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium. Crit Care Med. 2002;30:218
  10. Iba T, Kidokoro A, Kukunaga M, et al. Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B challenged mouse. J Trauma. 2003;55:546
  11. Inthorn D, Hoffmann JN, Hartl WH, et al. Antithrombin III supplementation in severe sepsis: Beneficial effects on organ dysfunction. Shock. 1997;8:328
  12. Wiedermann CJ, Hoffmann JN, Juers M, et al. High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety. Crit Care Med. 2006;34:285
  13. Osborn TM, Nguyen HB, Rivers EP. Emergency medicine and the surviving sepsis campaign: An international approach to managing severe sepsis and septic shock. Ann Emerg Med. 2005;46:228
  14. Pittner A, Nalos M, Asfar P, et al. Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxinemia. Intensive Care Med. 2003;29:312
  15. Brackstad OG, Aasbakk K, Maeland JA. Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol. 1992;30:1654
  16. Becker K, Harmsen D, Mellmann A, et al. Development and evaluation of a quality-controlled ribosomal sequence database for 16S rDNA-based identification of Staphylococcus species. J Clin Microbiol. 2004;42:4988
  17. Syk I, Ågren MS, Adawi D, et al. Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model. Br J Surg. 2001;88:228
  18. Brutzki TC, Kulczycky MJ, Bardossy L, et al. Rapid in vivo induction of leukocyte tissue factor mRNA and protein synthesis following low dose endotoxin administration to rabbits. Hematol J. 2001;2:188
  19. Cerwinka WH, Cooper D, Krieglstein CF, et al. Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. Am J Physiol Heart Circ Physiol. 2003;284:H535
  20. Hoffmann JN, Vollmar B, Laschke MW, et al. Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia. Crit Care Med. 2004;32:1011
  21. Suzuki Y, Deitch EA, Mishima S, et al. Endotoxin-induced mesenteric microvascular changes involve iNOS-derived nitric oxide: Results from a study using iNOS knock out mice. Shock. 2000;13:397
  22. Eskandari MK, Kalff JC, Billiar TR, et al. LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity. Am J Physiol. 1999;277:G478
  23. Sablotzki A, Mühling J, Czeslick E. Sepsis and multiple organ failure - update of current therapeutic concepts. Anästhesiol Intensivmed Notfallmed Schmerzther. 2005;40:511
  24. Spates ST, Cullen JJ, Ephgrave KS, et al. Effect of endotoxin on canine colonic motility and treatment. J Gastrointest Surg. 1998;2:391
  25. Schuster HP. ATIII in septicemia with DIC. Intensive Care Med. 1993;19(Suppl 1):S16
  26. Nakajima Y, Baudry N, Duranteau J, et al. Microcirculation in intestinal villi: A comparison between hemorrhagic and endotoxin shock. Am J Resp Crit Care Med. 2001;164:1526
  27. Koruda MJ, Rolandelli RH. Experimental studies on the healing of colonic anastomoses. J Surg Res. 1990;48:504
  28. Jacobi CA, Zieren HU, Sabat R, et al. Comparison of local and systemic inflammation after laparotomy or laparoscopy in the rat sepsis model. Langenbecks Arch Chir. 1997;382(4 Suppl. 1):S9
  29. Hiki N, Shimizu N, Imamura K, et al. Manipulation of the small intestine as a cause of increased inflammatory response after open compared with laparoscopic surgery. Br J Surg. 2006;93:195
  30. Esmon CT. Role of coagulation inhibitors in inflammation. Thromb Haemostat. 2001;86:51
  31. Eisenhut T, Sinha B, Grottrup-Wolfers E, et al. Prostacyclin analogs suppress the synthesis of tumor necrosis factor-alpha in LPS-stimulated human peripheral blood mononuclear cells. Immunopharmacology. 1993;26:259
  32. Woodmann RC, Teoh D, Payne D, et al. Thrombin and leukocyte recruitment in endotoxemia. Am J Physiol Heart Circ Physiol. 2000;279:H1338
  33. Wilson RF, Mammen EF, Tyburski JG, et al. Antithrombin levels related to infections and outcome. J Trauma. 1996;40:384
  34. Massignon D, Lepape A, Bienvenu J, et al. Coagulation/fibrinolysis balance in septic shock related to cytokines and clinical state. Haemostasis. 1994;24:36

PII: S0022-4804(08)00651-3

doi: 10.1016/j.jss.2008.10.008

Journal of Surgical Research
Volume 157, Issue 1 , Pages 4-13 , November 2009